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    Sart1 squamous cell carcinoma antigen recognized by T cells 1 [ Mus musculus (house mouse) ]

    Gene ID: 20227, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Sart1provided by MGI
    Official Full Name
    squamous cell carcinoma antigen recognized by T cells 1provided by MGI
    Primary source
    MGI:MGI:1309453
    See related
    Ensembl:ENSMUSG00000039148 AllianceGenome:MGI:1309453
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    U5-110K
    Summary
    Predicted to be involved in mRNA cis splicing, via spliceosome; maturation of 5S rRNA; and positive regulation of cytotoxic T cell differentiation. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in Cajal body; Golgi apparatus; and nuclear speck. Predicted to be part of U2-type precatalytic spliceosome; U4/U6 x U5 tri-snRNP complex; and catalytic step 2 spliceosome. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and integumental system. Orthologous to human SART1 (spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 15.0), CNS E14 (RPKM 7.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    19 A; 19 4.31 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (5427551..5438731, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (5377523..5388703, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene cystatin E/M Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:5366783-5366974 Neighboring gene BAF nuclear assembly factor 1 Neighboring gene eukaryotic translation initiation factor 1A domain containing Neighboring gene RIKEN cDNA D330050I16 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:5389816-5390049 Neighboring gene testis specific 10 interacting protein Neighboring gene RIKEN cDNA 4930481A15 gene Neighboring gene STARR-positive B cell enhancer ABC_E11669 Neighboring gene predicted gene, 54050

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Epitope tagging of proteins at the native chromosomal loci of genes in mice and in cultured vertebrate cells. Chen YI, et al. J Mol Biol, 2006 Aug 18. PMID 16859702
    2. A new transacting factor that modulates hypoxia-induced expression of the erythropoietin gene. Gupta M, et al. Blood, 2000 Jul 15. PMID 10887110
    3. Sequence analysis of genes encoding rodent homologues of the human tumor-rejection antigen SART-1. Gotoh M, et al. Jpn J Cancer Res, 1998 Aug. PMID 9765622, Free PMC Article
    4. A new HIF-1α/RANTES-driven pathway to hepatocellular carcinoma mediated by germline haploinsufficiency of SART1/HAF in mice. Koh MY, et al. Hepatology, 2016 May. PMID 26799785, Free PMC Article
    5. Intron loss in the SART1 genes of Fugu rubripes and Tetraodon nigroviridis. Bolland DJ, et al. Gene, 2001 Jun 13. PMID 11410364

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SART1(+/-) mice showed significant up-regulation of HIF-1alpha in circulating and liver-infiltrating immune cells
      Title: A new HIF-1α/RANTES-driven pathway to hepatocellular carcinoma mediated by germline haploinsufficiency of SART1/HAF in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA cis splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in maturation of 5S rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cytotoxic T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Cajal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2-type precatalytic spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U4/U6 x U5 tri-snRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U4/U6 x U5 tri-snRNP complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    U4/U6.U5 tri-snRNP-associated protein 1
    Names
    SART-1
    hypoxia-associated factor
    mSART-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016882.3 → NP_058578.3  U4/U6.U5 tri-snRNP-associated protein 1

      See identical proteins and their annotated locations for NP_058578.3

      Status: VALIDATED

      Source sequence(s)
      AB014721, AC122861
      Consensus CDS
      CCDS29460.1
      UniProtKB/Swiss-Prot
      Q8K155, Q9R1I9, Q9R270, Q9Z315
      Related
      ENSMUSP00000047397.5, ENSMUST00000044207.5
      Conserved Domains (1) summary
      pfam03343
      Location:118 → 759
      SART-1; SART-1 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      5427551..5438731 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250798.2 → XP_030106658.1  U4/U6.U5 tri-snRNP-associated protein 1 isoform X1

      Conserved Domains (1) summary
      pfam03343
      Location:2 → 601
      SART-1; SART-1 family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z315.1 GenPept UniProtKB/Swiss-Prot:Q9Z315

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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