Rxrg retinoid X receptor gamma [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rxrgprovided by MGI
Official Full Name: retinoid X receptor gammaprovided by MGI
Primary source: MGI:MGI:98216
See related: Ensembl:ENSMUSG00000015843 AllianceGenome:MGI:98216
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nr2b3
Summary: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; identical protein binding activity; and nuclear receptor activity. Acts upstream of or within positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus and retinoic acid receptor signaling pathway. Predicted to be located in nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; musculature; and sensory organ. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human RXRG (retinoid X receptor gamma). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in heart adult (RPKM 24.1), CNS E18 (RPKM 10.1) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H2.3; 1 74.99 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (167425902..167467191)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (167598362..167639623)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RXRgamma attenuates cerebral ischemia-reperfusion induced ferroptosis in neurons in mice through transcriptionally promoting the expression of GPX4.
Title: RXRγ attenuates cerebral ischemia-reperfusion induced ferroptosis in neurons in mice through transcriptionally promoting the expression of GPX4.
Loss of retinoid X receptor gamma subunit impairs group 1 mGluR mediated electrophysiological responses and group 1 mGluR dependent behaviors.
Title: Loss of retinoid X receptor gamma subunit impairs group 1 mGluR mediated electrophysiological responses and group 1 mGluR dependent behaviors.
Data show that halcinonide and clobetasol act as Smoothened (Smo) agonists to up-regulate myelin gene expression and retinoid X receptor gamma (RxRgamma) activation.
Title: Clobetasol and Halcinonide Act as Smoothened Agonists to Promote Myelin Gene Expression and RxRγ Receptor Activation.
RXR-gamma plays an important role in tight control of glucose metabolism in the fasting-feeding cycle.The regulation of RXR-gamma expression in the liver by feeding or glucose.
Title: Regulation of retinoid X receptor gamma expression by fed state in mouse liver.
Using the light-induced retinal degeneration (LIRD) mouse model, which provides a unique platform for exploring the mechanisms underlying neuritogenesis, we found that retinoid X receptors (RXRs) control neuritogenesis.
Title: Retinoid receptors trigger neuritogenesis in retinal degenerations.
The data of this study argued that control of NAc dopamine d2 receptor expression is critical for Retinoid x receptor gamma-mediated modulation of affective behaviors.
Title: Retinoid x receptor gamma control of affective behaviors involves dopaminergic signaling in mice.
RXR/LXR up-regulates SREBP1c gene expression and FOXO1 antagonizes this effect of RXR/LXR in skeletal muscle.
Title: Regulation of SREBP1c gene expression in skeletal muscle: role of retinoid X receptor/liver X receptor and forkhead-O1 transcription factor.
The ablation of all RXR (alpha, beta and gamma isotypes) in Sertoli cells does not recapitulate the phenotype generated upon ablation of all three retinoic acid receptors.
Title: Prepubertal testis development relies on retinoic acid but not rexinoid receptors in Sertoli cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

WI-15938 (e-PCR)
- UniSTS:18182

Rxrg (e-PCR), detects polymorphism
- UniSTS:546588

PMC314362P1 (e-PCR)
- UniSTS:272945

Rxrg (e-PCR), detects polymorphism
- UniSTS:507203

Rxrg (e-PCR), detects polymorphism
- UniSTS:186542

G49228 (e-PCR)
- UniSTS:108984

G49237 (e-PCR)
- UniSTS:108993

NoName (e-PCR)
- UniSTS:548566

Rxrg (e-PCR), detects polymorphism
- UniSTS:536548

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular condensate scaffold activity	ISO Inferred from Sequence Orthology more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables nuclear steroid receptor activity	IEA Inferred from Electronic Annotation more info
enables retinoic acid-responsive element binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IGI Inferred from Genetic Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anatomical structure development	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of myelination	ISO Inferred from Sequence Orthology more info
involved_in response to retinoic acid	IBA Inferred from Biological aspect of Ancestor more info
involved_in retinoic acid receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within retinoic acid receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: retinoic acid receptor RXR-gamma

Names: nuclear receptor subfamily 2 group B member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159731.2 → NP_001153203.1 retinoic acid receptor RXR-gamma isoform 2

See identical proteins and their annotated locations for NP_001153203.1

Status: VALIDATED

Source sequence(s)

AC093318, AC093452

Consensus CDS

CCDS48435.1

UniProtKB/TrEMBL

E9Q9V9

Related

ENSMUSP00000107011.2, ENSMUST00000111380.2

Conserved Domains (2) summary

cd06943
Location:110 → 318

NR_LBD_RXR_like; The ligand binding domain of the retinoid X receptor and Ultraspiracle, members of nuclear receptor superfamily

cd06956
Location:14 → 90

NR_DBD_RXR; DNA-binding domain of retinoid X receptor (RXR) is composed of two C4-type zinc fingers
NM_001420495.1 → NP_001407424.1 retinoic acid receptor RXR-gamma isoform 3

Status: VALIDATED

Source sequence(s)

AC093318, AC093452
NM_001420496.1 → NP_001407425.1 retinoic acid receptor RXR-gamma isoform 4

Status: VALIDATED

Source sequence(s)

AC093318, AC093452

UniProtKB/TrEMBL

E9Q9V9
NM_009107.4 → NP_033133.1 retinoic acid receptor RXR-gamma isoform 1

See identical proteins and their annotated locations for NP_033133.1

Status: VALIDATED

Source sequence(s)

AC093318, AC093452

Consensus CDS

CCDS15459.1

UniProtKB/Swiss-Prot

P28705

Related

ENSMUSP00000015987.4, ENSMUST00000015987.10

Conserved Domains (3) summary

cd06943
Location:233 → 441

NR_LBD_RXR_like; The ligand binding domain of the retinoid X receptor and Ultraspiracle, members of nuclear receptor superfamily

cd06956
Location:137 → 213

NR_DBD_RXR; DNA-binding domain of retinoid X receptor (RXR) is composed of two C4-type zinc fingers

pfam11825
Location:25 → 133

Nuc_recep-AF1; Nuclear/hormone receptor activator site AF-1