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    Rtkn rhotekin [ Mus musculus (house mouse) ]

    Gene ID: 20166, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Rtknprovided by MGI
    Official Full Name
    rhotekinprovided by MGI
    Primary source
    MGI:MGI:107371
    See related
    Ensembl:ENSMUSG00000034930 AllianceGenome:MGI:107371
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables GTPase inhibitor activity and small GTPase binding activity. Predicted to be involved in several processes, including Rho protein signal transduction; cytoskeleton-dependent cytokinesis; and septin ring organization. Predicted to act upstream of or within apoptotic process. Predicted to be located in cytosol. Predicted to be active in actomyosin contractile ring. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; liver and biliary system; and reproductive system. Orthologous to human RTKN (rhotekin). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 11.3), duodenum adult (RPKM 8.2) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rtkn in Genome Data Viewer
    Location:
    6 C3; 6 35.94 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (83112485..83129560)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (83135505..83152579)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E344 Neighboring gene WW domain binding protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E9669 Neighboring gene INO80 complex subunit B Neighboring gene RIKEN cDNA 1700003E16 gene Neighboring gene WD repeat domain 54

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. cGMP-dependent protein kinase I is involved in neurite outgrowth via a Rho effector, rhotekin, in Neuro2A neuroblastoma cells. Yuasa K, et al. Biochem Biophys Res Commun, 2012 May 4. PMID 22503686
    2. RhoA GTPase regulates B cell receptor signaling. Saci A, et al. Mol Cell, 2005 Jan 21. PMID 15664190
    3. Molecular cloning, expression characterization, and mapping of a novel putative inhibitor of rho GTPase activity, RTKN, to D2S145-D2S286. Fu Q, et al. Genomics, 2000 Jun 15. PMID 10873388
    4. Effect of cancer-associated mutations in the PlexinB1 gene. Zhou C, et al. Mol Cancer, 2012 Mar 9. PMID 22404908, Free PMC Article
    5. High blood pressure arising from a defect in vascular function. Michael SK, et al. Proc Natl Acad Sci U S A, 2008 May 6. PMID 18448676, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. these findings suggest that cGK-Ialpha interacts with and phosphorylates rhotekin, thereby contributing to neurite outgrowth regulation.
      Title: cGMP-dependent protein kinase I is involved in neurite outgrowth via a Rho effector, rhotekin, in Neuro2A neuroblastoma cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actomyosin contractile ring assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in septin ring organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actomyosin contractile ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    rhotekin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136227.2 → NP_001129699.1  rhotekin isoform a

      See identical proteins and their annotated locations for NP_001129699.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shortest transcript and encodes isoform a.
      Source sequence(s)
      AC104324
      Consensus CDS
      CCDS51817.1
      UniProtKB/Swiss-Prot
      E9QM24, Q61192, Q8C6B2, Q8VIG7
      Related
      ENSMUSP00000065571.5, ENSMUST00000065512.11
      Conserved Domains (4) summary
      smart00742
      Location:37 → 91
      Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
      pfam00169
      Location:333 → 411
      PH; PH domain
      pfam08174
      Location:117 → 270
      Anillin; Cell division protein anillin
      cl17171
      Location:309 → 419
      PH-like; Pleckstrin homology-like domain

    2. NM_001355524.2 → NP_001342453.2  rhotekin isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (c) is longer and has a distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AC104324

    3. NM_001355525.2 → NP_001342454.2  rhotekin isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, 5' coding region, 3' coding region, and 3' UTR, compared to variant 1. The resulting isoform (d) is shorter and has distinct N- and C-termini, compared to isoform a.
      Source sequence(s)
      AC104324

    4. NM_001410312.1 → NP_001397241.1  rhotekin isoform e

      Status: VALIDATED

      Source sequence(s)
      AC104324

    5. NM_001410313.1 → NP_001397242.1  rhotekin isoform e

      Status: VALIDATED

      Source sequence(s)
      AC104324

    6. NM_001410314.1 → NP_001397243.1  rhotekin isoform f

      Status: VALIDATED

      Source sequence(s)
      AC104324

    7. NM_001410315.1 → NP_001397244.1  rhotekin isoform g

      Status: VALIDATED

      Source sequence(s)
      AC104324

    8. NM_001410316.1 → NP_001397245.1  rhotekin isoform h

      Status: VALIDATED

      Source sequence(s)
      AC104324

    9. NM_009106.3 → NP_033132.2  rhotekin isoform b

      See identical proteins and their annotated locations for NP_033132.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (b) is shorter and has a distinct N-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AC104324
      Consensus CDS
      CCDS20274.1
      UniProtKB/Swiss-Prot
      Q8C6B2
      Related
      ENSMUSP00000112501.2, ENSMUST00000121093.8
      Conserved Domains (4) summary
      smart00742
      Location:23 → 78
      Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
      pfam00169
      Location:320 → 398
      PH; PH domain
      pfam08174
      Location:104 → 257
      Anillin; Cell division protein anillin
      cl17171
      Location:296 → 406
      PH-like; Pleckstrin homology-like domain

    10. NM_133641.3 → NP_598396.2  rhotekin isoform b

      See identical proteins and their annotated locations for NP_598396.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (b) is shorter and has a distinct N-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AC104324
      Consensus CDS
      CCDS20274.1
      UniProtKB/Swiss-Prot
      Q8C6B2
      Related
      ENSMUSP00000085249.5, ENSMUST00000087938.11
      Conserved Domains (4) summary
      smart00742
      Location:23 → 78
      Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
      pfam00169
      Location:320 → 398
      PH; PH domain
      pfam08174
      Location:104 → 257
      Anillin; Cell division protein anillin
      cl17171
      Location:296 → 406
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      83112485..83129560
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505810.5 → XP_006505873.1  rhotekin isoform X4

      See identical proteins and their annotated locations for XP_006505873.1

      Conserved Domains (3) summary
      pfam08174
      Location:67 → 220
      Anillin; Cell division protein anillin
      cl00087
      Location:1 → 41
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
      cl17171
      Location:259 → 314
      PH-like; Pleckstrin homology-like domain

    2. XM_006505807.3 → XP_006505870.1  rhotekin isoform X2

      Conserved Domains (3) summary
      smart00742
      Location:37 → 91
      Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
      pfam08174
      Location:117 → 270
      Anillin; Cell division protein anillin
      cl17171
      Location:309 → 364
      PH-like; Pleckstrin homology-like domain

    3. XM_006505808.3 → XP_006505871.1  rhotekin isoform X3

      See identical proteins and their annotated locations for XP_006505871.1

      Conserved Domains (3) summary
      smart00742
      Location:23 → 78
      Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
      pfam08174
      Location:104 → 257
      Anillin; Cell division protein anillin
      cl17171
      Location:296 → 351
      PH-like; Pleckstrin homology-like domain

    4. XM_006505809.3 → XP_006505872.1  rhotekin isoform X3

      See identical proteins and their annotated locations for XP_006505872.1

      Conserved Domains (3) summary
      smart00742
      Location:23 → 78
      Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
      pfam08174
      Location:104 → 257
      Anillin; Cell division protein anillin
      cl17171
      Location:296 → 351
      PH-like; Pleckstrin homology-like domain

    5. XM_006505811.3 → XP_006505874.1  rhotekin isoform X4

      See identical proteins and their annotated locations for XP_006505874.1

      Conserved Domains (3) summary
      pfam08174
      Location:67 → 220
      Anillin; Cell division protein anillin
      cl00087
      Location:1 → 41
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
      cl17171
      Location:259 → 314
      PH-like; Pleckstrin homology-like domain

    6. XM_030255274.2 → XP_030111134.1  rhotekin isoform X7

      Conserved Domains (3) summary
      smart00742
      Location:23 → 78
      Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
      pfam08174
      Location:104 → 257
      Anillin; Cell division protein anillin
      cl17171
      Location:296 → 406
      PH-like; Pleckstrin homology-like domain

    7. XM_006505805.4 → XP_006505868.1  rhotekin isoform X1

      Conserved Domains (3) summary
      smart00742
      Location:82 → 135
      Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
      pfam08174
      Location:161 → 314
      Anillin; Cell division protein anillin
      cl17171
      Location:353 → 408
      PH-like; Pleckstrin homology-like domain

    8. XM_006505812.2 → XP_006505875.1  rhotekin isoform X4

      See identical proteins and their annotated locations for XP_006505875.1

      Conserved Domains (3) summary
      pfam08174
      Location:67 → 220
      Anillin; Cell division protein anillin
      cl00087
      Location:1 → 41
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
      cl17171
      Location:259 → 314
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C6B2.3 GenPept UniProtKB/Swiss-Prot:Q8C6B2

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