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    Rps15 ribosomal protein S15 [ Mus musculus (house mouse) ]

    Gene ID: 20054, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Rps15provided by MGI
    Official Full Name
    ribosomal protein S15provided by MGI
    Primary source
    MGI:MGI:98117
    See related
    Ensembl:ENSMUSG00000063457 AllianceGenome:MGI:98117
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    rig
    Summary
    Predicted to enable MDM2/MDM4 family protein binding activity and ubiquitin ligase inhibitor activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in positive regulation of signal transduction by p53 class mediator and ribosome biogenesis. Predicted to be located in cytosolic ribosome and nucleoplasm. Predicted to be part of cytosolic small ribosomal subunit. Orthologous to human RPS15 (ribosomal protein S15). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 713.3), liver E14 (RPKM 562.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 C1; 10 39.72 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80128265..80129948)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80292431..80294114)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene DAZ associated protein 1 Neighboring gene microRNA 6911 Neighboring gene predicted gene 15122 Neighboring gene STARR-positive B cell enhancer ABC_E5154 Neighboring gene APC regulator of WNT signaling pathway 2 Neighboring gene STARR-positive B cell enhancer ABC_E8347 Neighboring gene RIKEN cDNA 2310011J03 gene Neighboring gene STARR-positive B cell enhancer ABC_E5155 Neighboring gene proprotein convertase subtilisin/kexin type 4 Neighboring gene STARR-positive B cell enhancer ABC_E366

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression of the rig gene in mouse oocytes and early embryos. Taylor KD, et al. Mol Reprod Dev, 1991 Apr. PMID 2064774
    2. Nucleotide sequence determination of mouse, chicken and Xenopus laevis rig cDNAs: the rig-encoded protein is extremely conserved during vertebrate evolution. Sugawara A, et al. Biochem Biophys Res Commun, 1990 Feb 14. PMID 2154983
    3. Expression of ribosomal protein genes in mouse oocytes and early embryos. Taylor KD, et al. Mol Reprod Dev, 1992 Mar. PMID 1554502
    4. Cloning of mouse genomic ribosomal protein L6 gene and analysis of its promoter. Wang J, et al. Biochim Biophys Acta, 2002 Jun 7. PMID 12031506
    5. Protein NPM3 interacts with the multifunctional nucleolar protein B23/nucleophosmin and inhibits ribosome biogenesis. Huang N, et al. J Biol Chem, 2005 Feb 18. PMID 15596447

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MDM2/MDM4 family protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin ligase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of signal transduction by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosomal small subunit assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal small subunit assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosomal small subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosomal small subunit export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytosolic small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic small ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic small ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytosolic small ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of small ribosomal subunit IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    small ribosomal subunit protein uS19
    Names
    40S ribosomal protein S15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310726.1 → NP_001297655.1  small ribosomal subunit protein uS19 isoform 2

      See identical proteins and their annotated locations for NP_001297655.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC140229
      Consensus CDS
      CCDS78858.1
      UniProtKB/TrEMBL
      D3YTQ9, Q3UK70
      Related
      ENSMUSP00000100997.2, ENSMUST00000062674.7
      Conserved Domains (1) summary
      cl00350
      Location:1 → 116
      Ribosomal_S19; Ribosomal protein S19

    2. NM_009091.2 → NP_033117.1  small ribosomal subunit protein uS19 isoform 1

      See identical proteins and their annotated locations for NP_033117.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AA027738, AV569793
      Consensus CDS
      CCDS35978.1
      UniProtKB/Swiss-Prot
      P62843, Q52KC9
      UniProtKB/TrEMBL
      Q3UK70
      Related
      ENSMUSP00000069004.8, ENSMUST00000068408.14
      Conserved Domains (1) summary
      PTZ00096
      Location:1 → 143
      PTZ00096; 40S ribosomal protein S15; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      80128265..80129948
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62843.2 GenPept UniProtKB/Swiss-Prot:P62843

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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