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    Polr1d polymerase (RNA) I polypeptide D [ Mus musculus (house mouse) ]

    Gene ID: 20018, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Polr1dprovided by MGI
    Official Full Name
    polymerase (RNA) I polypeptide Dprovided by MGI
    Primary source
    MGI:MGI:108403
    See related
    Ensembl:ENSMUSG00000029642 AllianceGenome:MGI:108403
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AC19; RPA16; Rpo1-3; 1110003G10Rik
    Summary
    This gene encodes an RNA polymerase subunit that is a component of both the RNA polymerase I and RNA polymerase III complexes. RNA polymerase I is associated with transcription of pre-ribosomal RNAs, while RNA polymerase III is associated with transcription of small RNAs. Pseudogenes of this gene have been defined on chromosomes 4 and 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]
    Expression
    Ubiquitous expression in testis adult (RPKM 34.1), placenta adult (RPKM 28.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 G3; 5 86.73 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (147013525..147048171)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (147076715..147111361)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46936 Neighboring gene ligand of numb-protein X 2 Neighboring gene STARR-positive B cell enhancer ABC_E6405 Neighboring gene STARR-positive B cell enhancer ABC_E6406 Neighboring gene STARR-seq mESC enhancer starr_14866 Neighboring gene STARR-positive B cell enhancer ABC_E2184 Neighboring gene STARR-positive B cell enhancer ABC_E8092 Neighboring gene ribosomal protein S10, pseudogene 4 Neighboring gene STARR-seq mESC enhancer starr_14868 Neighboring gene predicted gene, 34994 Neighboring gene GS homeobox 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse RNA polymerase I 16-kDa subunit able to associate with 40-kDa subunit is a homolog of yeast AC19 subunit of RNA polymerases I and III. Yao Y, et al. J Biol Chem, 1996 Dec 20. PMID 8955128
    2. Loss of POLR1D results in embryonic lethality prior to blastocyst formation in mice. Miao X, et al. Mol Reprod Dev, 2020 Nov. PMID 33022126, Free PMC Article
    3. Dynamic regulation and requirement for ribosomal RNA transcription during mammalian development. Falcon KT, et al. Proc Natl Acad Sci U S A, 2022 Aug 2. PMID 35881792, Free PMC Article
    4. Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription. Yamamoto K, et al. Mol Cell Biol, 2004 Jul. PMID 15226435, Free PMC Article
    5. RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse. Hüttenhofer A, et al. EMBO J, 2001 Jun 1. PMID 11387227, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of POLR1D results in embryonic lethality prior to blastocyst formation in mice.
      Title: Loss of POLR1D results in embryonic lethality prior to blastocyst formation in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC107156, 1110003G10Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed 5'-3' RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to RNA polymerase I activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase III activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription by RNA polymerase III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription elongation by RNA polymerase I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of DNA-directed RNA polymerase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of RNA polymerase I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase I complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of RNA polymerase I complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of RNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase III complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA-directed RNA polymerases I and III subunit RPAC2
    Names
    DNA-directed RNA polymerase I 16 kDa polypeptide
    RNA polymerase 1-3
    RNA polymerases I and III subunit AC2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009087.2 → NP_033113.1  DNA-directed RNA polymerases I and III subunit RPAC2 isoform 1

      See identical proteins and their annotated locations for NP_033113.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1).
      Source sequence(s)
      AA023617, AK002811, BM948930
      Consensus CDS
      CCDS19876.1
      UniProtKB/Swiss-Prot
      P97304
      UniProtKB/TrEMBL
      Q545W2
      Related
      ENSMUSP00000058355.4, ENSMUST00000050970.4
      Conserved Domains (1) summary
      cd07029
      Location:30 → 114
      RNAP_I_III_AC19; AC19 subunit of Eukaryotic RNA polymerase (RNAP) I and RNAP III

    2. NM_181730.4 → NP_859419.1  DNA-directed RNA polymerases I and III subunit RPAC2 isoform 2

      See identical proteins and their annotated locations for NP_859419.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      BC087884, BF462386, BM948930
      Consensus CDS
      CCDS39397.1
      UniProtKB/TrEMBL
      Q8R1M3, Q99M44, Q9D1M1
      Related
      ENSMUSP00000106186.2, ENSMUST00000110557.5

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      147013525..147048171
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254228.1 → XP_030110088.1  DNA-directed RNA polymerases I and III subunit RPAC2 isoform X1

      UniProtKB/TrEMBL
      Q8R1M3, Q99M44, Q9D1M1

    2. XM_030254231.1 → XP_030110091.1  DNA-directed RNA polymerases I and III subunit RPAC2 isoform X1

      UniProtKB/TrEMBL
      Q8R1M3, Q99M44, Q9D1M1

    3. XM_036164932.1 → XP_036020825.1  DNA-directed RNA polymerases I and III subunit RPAC2 isoform X1

      UniProtKB/TrEMBL
      Q8R1M3, Q99M44, Q9D1M1

    4. XM_030254230.1 → XP_030110090.1  DNA-directed RNA polymerases I and III subunit RPAC2 isoform X1

      UniProtKB/TrEMBL
      Q8R1M3, Q99M44, Q9D1M1

    5. XM_030254232.1 → XP_030110092.1  DNA-directed RNA polymerases I and III subunit RPAC2 isoform X1

      UniProtKB/TrEMBL
      Q8R1M3, Q99M44, Q9D1M1

    6. XM_030254229.1 → XP_030110089.1  DNA-directed RNA polymerases I and III subunit RPAC2 isoform X1

      UniProtKB/TrEMBL
      Q8R1M3, Q99M44, Q9D1M1

    7. XM_030254233.1 → XP_030110093.1  DNA-directed RNA polymerases I and III subunit RPAC2 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97304.1 GenPept UniProtKB/Swiss-Prot:P97304

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