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    Trim10 tripartite motif-containing 10 [ Mus musculus (house mouse) ]

    Gene ID: 19824, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Trim10provided by MGI
    Official Full Name
    tripartite motif-containing 10provided by MGI
    Primary source
    MGI:MGI:1338757
    See related
    Ensembl:ENSMUSG00000073400 AllianceGenome:MGI:1338757
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rnf9; Herf1
    Summary
    Predicted to enable ubiquitin protein ligase activity. Involved in innate immune response and negative regulation of viral entry into host cell. Acts upstream of or within erythrocyte differentiation. Located in cytoplasm. Is expressed in bone marrow; embryo; liver; spleen; and ureter. Orthologous to human TRIM10 (tripartite motif containing 10). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver E14 (RPKM 70.7), liver E14.5 (RPKM 69.9) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 B1; 17 19.16 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (37180388..37188725)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (36869496..36877833)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene tripartite motif-containing 26 Neighboring gene predicted gene, 25973 Neighboring gene tripartite motif-containing 15 Neighboring gene phosphatidylethanolamine binding protein 1 pseudogene Neighboring gene tripartite motif-containing 40

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Tripartite motif 10 regulates cardiac hypertrophy by targeting the PTEN/AKT pathway. Yang H, et al. J Cell Mol Med, 2020 Jun. PMID 32343488, Free PMC Article
    2. Downregulation of the Spi-1/PU.1 oncogene induces the expression of TRIM10/HERF1, a key factor required for terminal erythroid cell differentiation and survival. Blaybel R, et al. Cell Res, 2008 Aug. PMID 18560381
    3. Species-specific class I gene expansions formed the telomeric 1 mb of the mouse major histocompatibility complex. Takada T, et al. Genome Res, 2003 Apr. PMID 12671000, Free PMC Article
    4. HERF1, a novel hematopoiesis-specific RING finger protein, is required for terminal differentiation of erythroid cells. Harada H, et al. Mol Cell Biol, 1999 May. PMID 10207104, Free PMC Article
    5. TRIM E3 ligases interfere with early and late stages of the retroviral life cycle. Uchil PD, et al. PLoS Pathog, 2008 Feb 8. PMID 18248090, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The ubiquitin E3 ligase TRIM10 promotes STING aggregation and activation in the Golgi apparatus.
      Title: The ubiquitin E3 ligase TRIM10 promotes STING aggregation and activation in the Golgi apparatus.
    2. Tripartite motif 10 regulates cardiac hypertrophy by targeting the PTEN/AKT pathway.
      Title: Tripartite motif 10 regulates cardiac hypertrophy by targeting the PTEN/AKT pathway.
    3. Primary Spi-1/PU.1 downregulation acts on late erythroid differentiation through at least two pathways, one of which requires TRIM10/HERF1 upregulation and parallels the Spi-1/PU.1-induced Fli-1 shutoff regulatory cascade.
      Title: Downregulation of the Spi-1/PU.1 oncogene induces the expression of TRIM10/HERF1, a key factor required for terminal erythroid cell differentiation and survival.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within erythrocyte differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of viral entry into host cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tripartite motif-containing protein 10
    Names
    hematopoietic RING finger 1
    ring finger protein 9
    tripartite motif protein 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001424810.1 → NP_001411739.1  tripartite motif-containing protein 10 isoform 1

      Status: VALIDATED

      Source sequence(s)
      CR956641

    2. NM_011280.2 → NP_035410.2  tripartite motif-containing protein 10 isoform 2

      See identical proteins and their annotated locations for NP_035410.2

      Status: VALIDATED

      Source sequence(s)
      AI324236, AK011082, BY712181
      Consensus CDS
      CCDS37614.1
      UniProtKB/Swiss-Prot
      Q80WA9, Q9CY03, Q9WUH5
      Related
      ENSMUSP00000057928.10, ENSMUST00000060524.11
      Conserved Domains (3) summary
      cd00021
      Location:97 → 135
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      pfam15227
      Location:16 → 60
      zf-C3HC4_4; zinc finger of C3HC4-type, RING
      cd15827
      Location:309 → 480
      SPRY_PRY_TRIM10; PRY/SPRY domain of tripartite motif-binding protein 10 (TRIM10) also known as hematopoietic RING finger 1 (HERF1)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      37180388..37188725
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317359.1 → XP_017172848.1  tripartite motif-containing protein 10 isoform X1

      Conserved Domains (3) summary
      cd15827
      Location:324 → 495
      SPRY_PRY_TRIM10; PRY/SPRY domain of tripartite motif-binding protein 10 (TRIM10) also known as hematopoietic RING finger 1 (HERF1)
      cd16593
      Location:13 → 61
      RING-HC_TRIM10_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 10 (TRIM10) and similar proteins
      cl00034
      Location:99 → 135
      Bbox_SF; B-box-type zinc finger superfamily

    2. XM_017317361.1 → XP_017172850.1  tripartite motif-containing protein 10 isoform X3

      Conserved Domains (3) summary
      cd15827
      Location:316 → 487
      SPRY_PRY_TRIM10; PRY/SPRY domain of tripartite motif-binding protein 10 (TRIM10) also known as hematopoietic RING finger 1 (HERF1)
      cd16593
      Location:13 → 61
      RING-HC_TRIM10_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 10 (TRIM10) and similar proteins
      cl00034
      Location:99 → 135
      Bbox_SF; B-box-type zinc finger superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WUH5.2 GenPept UniProtKB/Swiss-Prot:Q9WUH5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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