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    Rit1 Ras-like without CAAX 1 [ Mus musculus (house mouse) ]

    Gene ID: 19769, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Rit1provided by MGI
    Official Full Name
    Ras-like without CAAX 1provided by MGI
    Primary source
    MGI:MGI:108053
    See related
    Ensembl:ENSMUSG00000028057 AllianceGenome:MGI:108053
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rit; RIBB; ROC1
    Summary
    Enables GTP binding activity. Predicted to be involved in Ras protein signal transduction. Located in plasma membrane. Is expressed in Meckel's cartilage; bone; hip; and rib. Used to study Noonan syndrome 8. Human ortholog(s) of this gene implicated in Noonan syndrome 8. Orthologous to human RIT1 (Ras like without CAAX 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 14.8), heart adult (RPKM 14.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    3 F1; 3 38.95 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (88624154..88638354)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (88716842..88731048)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene relaxin family peptide receptor 4 Neighboring gene STARR-seq mESC enhancer starr_08214 Neighboring gene STARR-positive B cell enhancer ABC_E2077 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:88490214-88490323 Neighboring gene KH domain containing 4, pre-mRNA splicing factor Neighboring gene predicted gene, 25820 Neighboring gene STARR-positive B cell enhancer ABC_E2669 Neighboring gene STARR-seq mESC enhancer starr_08216 Neighboring gene predicted gene 10253 Neighboring gene synaptotagmin XI Neighboring gene STARR-positive B cell enhancer ABC_E4551 Neighboring gene STARR-positive B cell enhancer ABC_E3444

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Small GTPase RIT1 in Mouse Retina; Cellular and Functional Analysis. Mir S, et al. Curr Eye Res, 2018 Sep. PMID 29843527, Free PMC Article
    2. Rit GTPase signaling promotes immature hippocampal neuronal survival. Cai W, et al. J Neurosci, 2012 Jul 18. PMID 22815504, Free PMC Article
    3. RIT1 GTPase Regulates Sox2 Transcriptional Activity and Hippocampal Neurogenesis. Mir S, et al. J Biol Chem, 2017 Feb 10. PMID 28007959, Free PMC Article
    4. Rit GTPase regulates a p38 MAPK-dependent neuronal survival pathway. Cai W, et al. Neurosci Lett, 2012 Dec 7. PMID 23123784, Free PMC Article
    5. An evolutionarily conserved Rit GTPase-p38 MAPK signaling pathway mediates oxidative stress resistance. Cai W, et al. Mol Biol Cell, 2011 Sep. PMID 21737674, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer.
      Title: Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer.
    2. RIT1 is widely expressed in the murine retina, including both Muller glia and RGCs. While genetic deletion of RIT1 does not result in gross retinal abnormalities
      Title: Small GTPase RIT1 in Mouse Retina; Cellular and Functional Analysis.
    3. we generated a novel knock-in Rit1A57G/+ mouse that presents features that are relevant to NS patients with a Rit1 mutation, including craniofacial dysmorphia, short stature, and cardiac hypertrophy.
      Title: New Noonan syndrome model mice with RIT1 mutation exhibit cardiac hypertrophy and susceptibility to β-adrenergic stimulation-induced cardiac fibrosis.
    4. In adult hippocampal neuronal precursor cells, RIT1 controls an Akt-dependent signaling cascade, resulting in the stabilization and transcriptional activation of phosphorylated Sox2. This study supports a role for RIT1 in relaying niche-derived signals to neural/stem progenitor cells to control transcription of genes involved in self-renewal and differentiation
      Title: RIT1 GTPase Regulates Sox2 Transcriptional Activity and Hippocampal Neurogenesis.
    5. the Rit-p38-MSK1/2 signaling pathway may have an important role in the stress-dependent regulation of CREB-dependent gene expression.
      Title: Rit-mediated stress resistance involves a p38-mitogen- and stress-activated protein kinase 1 (MSK1)-dependent cAMP response element-binding protein (CREB) activation cascade.
    6. these data identify a new and unexpected role for Rit in injury-induced neurogenesis, functioning as a selective survival mechanism for immature hippocampal neurons within the subgranular zone of the dentate gyrus following TBI.
      Title: Rit GTPase signaling promotes immature hippocampal neuronal survival.
    7. our studies establish the Rit GTPases as critical regulators of an evolutionarily conserved, p38 MAPK-dependent signaling cascade
      Title: An evolutionarily conserved Rit GTPase-p38 MAPK signaling pathway mediates oxidative stress resistance.
    8. Rin and Rit Bind to PAR6 GTP-dependently and regulate cell transformation
      Title: Small GTPase proteins Rin and Rit Bind to PAR6 GTP-dependently and regulate cell transformation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GDP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    GTP-binding protein Rit1
    Names
    RAS-like protein expressed in many tissues
    ras-like without CAAX protein 1
    NP_001156782.1
    NP_001390950.1
    NP_001390951.1
    NP_001390958.1
    NP_001390959.1
    NP_001390960.1
    NP_001390962.1
    NP_001390963.1
    NP_001390964.1
    NP_001390965.1
    NP_033095.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163310.2 → NP_001156782.1  GTP-binding protein Rit1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC134246
      Consensus CDS
      CCDS50952.1
      UniProtKB/TrEMBL
      E9Q672
      Related
      ENSMUSP00000130464.2, ENSMUST00000172252.2
      Conserved Domains (1) summary
      cl38936
      Location:1 → 155
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001404021.1 → NP_001390950.1  GTP-binding protein Rit1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC134246
      UniProtKB/Swiss-Prot
      P70426

    3. NM_001404022.1 → NP_001390951.1  GTP-binding protein Rit1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC134246
      UniProtKB/Swiss-Prot
      P70426

    4. NM_001404029.1 → NP_001390958.1  GTP-binding protein Rit1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC134246
      UniProtKB/TrEMBL
      E9Q672

    5. NM_001404030.1 → NP_001390959.1  GTP-binding protein Rit1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC134246
      UniProtKB/TrEMBL
      E9Q672

    6. NM_001404031.1 → NP_001390960.1  GTP-binding protein Rit1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC134246
      UniProtKB/TrEMBL
      E9Q672

    7. NM_001404033.1 → NP_001390962.1  GTP-binding protein Rit1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC134246

    8. NM_001404034.1 → NP_001390963.1  GTP-binding protein Rit1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC134246
      Related
      ENSMUST00000166234.2

    9. NM_001404035.1 → NP_001390964.1  GTP-binding protein Rit1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC134246

    10. NM_001404036.1 → NP_001390965.1  GTP-binding protein Rit1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC134246

    11. NM_009069.5 → NP_033095.1  GTP-binding protein Rit1 isoform 1

      See identical proteins and their annotated locations for NP_033095.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC134246
      Consensus CDS
      CCDS17484.1
      UniProtKB/Swiss-Prot
      P70426
      UniProtKB/TrEMBL
      A0A1S6GWG2
      Related
      ENSMUSP00000029692.9, ENSMUST00000029692.15
      Conserved Domains (1) summary
      cd04141
      Location:20 → 191
      Rit_Rin_Ric; Ras-like protein in all tissues (Rit), Ras-like protein in neurons (Rin) and Ras-related protein which interacts with calmodulin (Ric)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      88624154..88638354
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_028056.1: Suppressed sequence

      Description
      NR_028056.1: This RefSeq was removed because it is now thought that this transcript does encode a protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P70426.1 GenPept UniProtKB/Swiss-Prot:P70426

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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