Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ripk1provided by MGI
Official Full Name: receptor (TNFRSF)-interacting serine-threonine kinase 1provided by MGI
Primary source: MGI:MGI:108212
See related: Ensembl:ENSMUSG00000021408 AllianceGenome:MGI:108212
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RIP; Rinp; Rip1; RIP-1; D330015H01Rik
Summary: Enables protein homodimerization activity and protein serine/threonine kinase activity. Involved in several processes, including necroptotic signaling pathway; negative regulation of cardiac muscle cell proliferation; and regulation of signal transduction. Acts upstream of or within several processes, including positive regulation of I-kappaB kinase/NF-kappaB signaling; regulation of extrinsic apoptotic signaling pathway; and ripoptosome assembly involved in necroptotic process. Predicted to be located in several cellular components, including cytosol; membrane raft; and mitochondrion. Predicted to be part of death-inducing signaling complex; receptor complex; and ripoptosome. Is expressed in several structures, including central nervous system; heart; liver; lung; and tail. Human ortholog(s) of this gene implicated in immunodeficiency 57. Orthologous to human RIPK1 (receptor interacting serine/threonine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 4.7), lung adult (RPKM 4.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 A3.3; 13 14.01 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (34181072..34219153)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (34002225..34035170)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PARP5A and RNF146 phase separation restrains RIPK1-dependent necroptosis.
Title: PARP5A and RNF146 phase separation restrains RIPK1-dependent necroptosis.
Binding of RAGE and RIPK1 induces cognitive deficits in chronic hyperglycemia-derived neuroinflammation.
Title: Binding of RAGE and RIPK1 induces cognitive deficits in chronic hyperglycemia-derived neuroinflammation.
Inhibiting RIPK1-driven neuroinflammation and neuronal apoptosis mitigates brain injury following experimental subarachnoid hemorrhage.
Title: Inhibiting RIPK1-driven neuroinflammation and neuronal apoptosis mitigates brain injury following experimental subarachnoid hemorrhage.
RIPK1 activation in Mecp2-deficient microglia promotes inflammation and glutamate release in RTT.
Title: RIPK1 activation in Mecp2-deficient microglia promotes inflammation and glutamate release in RTT.
The role and mechanism of RIPK1 in vascular endothelial dysfunction in chronic kidney disease.
Title: The role and mechanism of RIPK1 in vascular endothelial dysfunction in chronic kidney disease.
RIPK1 plays a crucial role in maintaining regulatory T-Cell homeostasis by inhibiting both RIPK3- and FADD-mediated cell death.
Title: RIPK1 plays a crucial role in maintaining regulatory T-Cell homeostasis by inhibiting both RIPK3- and FADD-mediated cell death.
IKKepsilon and TBK1 prevent RIPK1 dependent and independent inflammation.
Title: IKKε and TBK1 prevent RIPK1 dependent and independent inflammation.
Excessive apoptosis of Rip1-deficient T cells leads to premature aging.
Title: Excessive apoptosis of Rip1-deficient T cells leads to premature aging.
Inhibitor of nuclear factor kappa B kinase subunit epsilon regulates murine acetaminophen toxicity via RIPK1/JNK.
Title: Inhibitor of nuclear factor kappa B kinase subunit epsilon regulates murine acetaminophen toxicity via RIPK1/JNK.
Caspase 6 promotes innate immune activation by functional crosstalk between RIPK1-IkappaBalpha axis in liver inflammation.
Title: Caspase 6 promotes innate immune activation by functional crosstalk between RIPK1-IκBα axis in liver inflammation.

Submit: New GeneRIF Correction See all GeneRIFs (233)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (13) 1 citation
Endonuclease-mediated (21) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

U25995 (e-PCR)
- UniSTS:160282

PMC316425P1 (e-PCR)
- UniSTS:272990

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables JUN kinase kinase kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables death domain binding	ISO Inferred from Sequence Orthology more info
enables death receptor binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein kinase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables signaling adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in T cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in amyloid fibril formation	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in cellular response to growth factor stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to hydrogen peroxide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
involved_in extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in extrinsic apoptotic signaling pathway via death domain receptors	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in necroptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within necroptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in necroptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in necroptotic process	ISO Inferred from Sequence Orthology more info
involved_in necroptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in necroptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of necroptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-serine autophosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-serine autophosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of NF-kappaB transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of execution phase of apoptosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-6-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of miRNA processing	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of necroptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of programmed cell death	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of programmed necrotic cell death	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transferase activity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within programmed cell death	IEA Inferred from Electronic Annotation more info
involved_in programmed necrotic cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autophosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of ATP:ADP antiporter activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of reactive oxygen species metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
involved_in ripoptosome assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ripoptosome assembly involved in necroptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in tumor necrosis factor-mediated signaling pathway	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of death-inducing signaling complex	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info
part_of ripoptosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: receptor-interacting serine/threonine-protein kinase 1

Names: cell death protein RIP; receptor-interacting protein 1; serine/threonine-protein kinase RIP

NP_001346926.1

EC 2.7.11.1

NP_033094.3

EC 2.7.11.1

XP_006516672.1

EC 2.7.11.1

XP_030103066.1

EC 2.7.11.1

XP_036013820.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001359997.1 → NP_001346926.1 receptor-interacting serine/threonine-protein kinase 1

Status: VALIDATED

Source sequence(s)

AC161117

Consensus CDS

CCDS26443.1

UniProtKB/Swiss-Prot

Q3U0J3, Q60855, Q8CD90

UniProtKB/TrEMBL

F7D1J2

Related

ENSMUSP00000021844.9, ENSMUST00000021844.15

Conserved Domains (2) summary

cd08777
Location:568 → 653

Death_RIP1; Death Domain of Receptor-Interacting Protein 1

cl21453
Location:23 → 291

PKc_like; Protein Kinases, catalytic domain
NM_009068.3 → NP_033094.3 receptor-interacting serine/threonine-protein kinase 1

See identical proteins and their annotated locations for NP_033094.3

Status: VALIDATED

Source sequence(s)

BC054542

Consensus CDS

CCDS26443.1

UniProtKB/Swiss-Prot

Q3U0J3, Q60855, Q8CD90

UniProtKB/TrEMBL

F7D1J2

Related

ENSMUSP00000129831.2, ENSMUST00000167374.9

Conserved Domains (2) summary

cd08777
Location:568 → 653

Death_RIP1; Death Domain of Receptor-Interacting Protein 1

cl21453
Location:23 → 291

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

34181072..34219153

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030247206.2 → XP_030103066.1 receptor-interacting serine/threonine-protein kinase 1 isoform X2

Conserved Domains (3) summary

cd08777
Location:375 → 460

Death_RIP1; Death Domain of Receptor-Interacting Protein 1

pfam12721
Location:303 → 343

RHIM; RIP homotypic interaction motif

cl21453
Location:1 → 98

PKc_like; Protein Kinases, catalytic domain
XM_006516609.5 → XP_006516672.1 receptor-interacting serine/threonine-protein kinase 1 isoform X1

See identical proteins and their annotated locations for XP_006516672.1

UniProtKB/Swiss-Prot

Q3U0J3, Q60855, Q8CD90

UniProtKB/TrEMBL

F7D1J2

Conserved Domains (2) summary

cd08777
Location:568 → 653

Death_RIP1; Death Domain of Receptor-Interacting Protein 1

cl21453
Location:23 → 291

PKc_like; Protein Kinases, catalytic domain
XM_036157927.1 → XP_036013820.1 receptor-interacting serine/threonine-protein kinase 1 isoform X1

UniProtKB/Swiss-Prot

Q3U0J3, Q60855, Q8CD90

UniProtKB/TrEMBL

F7D1J2

Conserved Domains (2) summary

cd08777
Location:568 → 653

Death_RIP1; Death Domain of Receptor-Interacting Protein 1

cl21453
Location:23 → 291

PKc_like; Protein Kinases, catalytic domain