Rit2 Ras-like without CAAX 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rit2provided by MGI
Official Full Name: Ras-like without CAAX 2provided by MGI
Primary source: MGI:MGI:108054
See related: Ensembl:ENSMUSG00000057455 AllianceGenome:MGI:108054
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rin; RIBA; Roc2
Summary: Enables several functions, including GTP binding activity; GTPase activity; and calmodulin binding activity. Involved in several processes, including Ras protein signal transduction; regulation of Cdc42 protein signal transduction; and regulation of neuron projection development. Located in several cellular components, including cell body; dendritic tree; and nucleus. Is expressed in central nervous system; lung; and neural retina. Orthologous to human RIT2 (Ras like without CAAX 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cerebellum adult (RPKM 36.4), CNS E18 (RPKM 18.8) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 B1; 18 17.69 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (31107367..31450181, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (30974314..31317128, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Conditional, inducible gene silencing in dopamine neurons reveals a sex-specific role for Rit2 GTPase in acute cocaine response and striatal function.
Title: Conditional, inducible gene silencing in dopamine neurons reveals a sex-specific role for Rit2 GTPase in acute cocaine response and striatal function.
Dopamine transporter trafficking and Rit2 GTPase: Mechanism of action and in vivo impact.
Title: Dopamine transporter trafficking and Rit2 GTPase: Mechanism of action and in vivo impact.
These studies confirm the expression of RIT2 in retinal neuronal cells.
Title: RIT2, a neuron-specific small guanosine triphosphatase, is expressed in retinal neuronal cells and its promoter is modulated by the POU4 transcription factors.
Rin and Rit Bind to PAR6 GTP-dependently and regulate cell transformation
Title: Small GTPase proteins Rin and Rit Bind to PAR6 GTP-dependently and regulate cell transformation.
stimulation of PC6 cells with either epidermal growth factor or nerve growth factor (NGF) results in rapid activation of Rin
Title: Nerve growth factor-dependent activation of the small GTPase Rin.
Neuron-specific small GTPase Rin is involved in downstream signaling of plexin B3.
Title: Plexin B3 promotes neurite outgrowth, interacts homophilically, and interacts with Rin.
The Ras-like small GTP-binding protein Rin is activated by growth factor stimulation
Title: The Ras-like small GTP-binding protein Rin is activated by growth factor stimulation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

U71202 (e-PCR)
- UniSTS:163601

RH28698 (e-PCR)
- UniSTS:85297

NoName (e-PCR)
- UniSTS:224185

RH140372 (e-PCR)
- UniSTS:222448

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein activity	IEA Inferred from Electronic Annotation more info
enables GDP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin binding	IPI Inferred from Physical Interaction more info	PubMed
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IGI Inferred from Genetic Interaction more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables semaphorin receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
NOT involved_in MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in Ras protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in Ras protein signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in maintenance of protein location in cell	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron projection development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neuron projection development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of Cdc42 protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
NOT involved_in regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in regulation of endocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cell body	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendritic tree	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: GTP-binding protein Rit2

Names: GTP-binding protein Roc2; RAS-like protein expressed in neuron; ras-like protein expressed in neurons; ras-like without CAAX protein 2

NP_033091.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009065.2 → NP_033091.1 GTP-binding protein Rit2

See identical proteins and their annotated locations for NP_033091.1

Status: PROVISIONAL

Source sequence(s)

BC018267

Consensus CDS

CCDS29108.1

UniProtKB/Swiss-Prot

P70425, Q3UST1, Q3UUP4, Q8BQT5, Q9QWX5

Related

ENSMUSP00000114323.2, ENSMUST00000153060.8

Conserved Domains (1) summary

cd04141
Location:19 → 190

Rit_Rin_Ric; Ras-like protein in all tissues (Rit), Ras-like protein in neurons (Rin) and Ras-related protein which interacts with calmodulin (Ric)