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    Rgl2 ral guanine nucleotide dissociation stimulator-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 19732, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Rgl2provided by MGI
    Official Full Name
    ral guanine nucleotide dissociation stimulator-like 2provided by MGI
    Primary source
    MGI:MGI:107483
    See related
    Ensembl:ENSMUSG00000041354 AllianceGenome:MGI:107483
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rlf; Rgt2; KE1.5; Rab2l
    Summary
    Enables guanyl-nucleotide exchange factor activity. Acts upstream of or within negative regulation of cardiac muscle cell apoptotic process; positive regulation of phosphatidylinositol 3-kinase signaling; and regulation of Ral protein signal transduction. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; integumental system; and nervous system. Orthologous to human RGL2 (ral guanine nucleotide dissociation stimulator like 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 47.5), spleen adult (RPKM 34.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 B1; 17 17.98 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34148813..34156661)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (33929514..33937687)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 22 Neighboring gene STARR-positive B cell enhancer ABC_E5592 Neighboring gene STARR-positive B cell enhancer ABC_E7521 Neighboring gene predicted gene, 19412 Neighboring gene TAP binding protein Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:34066718-34066827 Neighboring gene STARR-positive B cell enhancer ABC_E1938 Neighboring gene prefoldin subunit 6 Neighboring gene WD repeat domain 46

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The guanine nucleotide exchange factor Rlf interacts with SH3 domain-containing proteins via a binding site with a preselected conformation. Popovic M, et al. J Struct Biol, 2013 Sep. PMID 23891840
    2. Guanine nucleotide exchange factor-like factor (Rlf) induces gene expression and potentiates alpha 1-adrenergic receptor-induced transcriptional responses in neonatal rat ventricular myocytes. Post GR, et al. J Biol Chem, 2002 May 3. PMID 11847222
    3. The ral exchange factor rgl2 promotes cardiomyocyte survival and inhibits cardiac fibrosis. Scotland RL, et al. PLoS One, 2013. PMID 24069211, Free PMC Article
    4. RalGDS-like factor (Rlf) is a novel Ras and Rap 1A-associating protein. Wolthuis RM, et al. Oncogene, 1996 Jul 18. PMID 8710374
    5. Structure determination of the Ras-binding domain of the Ral-specific guanine nucleotide exchange factor Rlf. Esser D, et al. Biochemistry, 1998 Sep 29. PMID 9753431

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The crystal structure of the mouse Rgl2 REM- and a CDC25-homology domain.
      Title: The guanine nucleotide exchange factor Rlf interacts with SH3 domain-containing proteins via a binding site with a preselected conformation.
    2. induces gene expression and potentiates alpha 1-adrenergic receptor-induced transcriptional responses
      Title: Guanine nucleotide exchange factor-like factor (Rlf) induces gene expression and potentiates alpha 1-adrenergic receptor-induced transcriptional responses in neonatal rat ventricular myocytes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of cardiac muscle cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of Ral protein signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ral guanine nucleotide dissociation stimulator-like 2
    Names
    RalGDS-like factor
    ralGDS-like 2
    ras-associated protein RAB2L

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410640.1 → NP_001397569.1  ral guanine nucleotide dissociation stimulator-like 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      CR974462

    2. NM_001410641.1 → NP_001397570.1  ral guanine nucleotide dissociation stimulator-like 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      CR974462

    3. NM_001410645.1 → NP_001397574.1  ral guanine nucleotide dissociation stimulator-like 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      CR974462

    4. NM_001410646.1 → NP_001397575.1  ral guanine nucleotide dissociation stimulator-like 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      CR974462

    5. NM_001410647.1 → NP_001397576.1  ral guanine nucleotide dissociation stimulator-like 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      CR974462

    6. NM_009059.3 → NP_033085.2  ral guanine nucleotide dissociation stimulator-like 2 isoform 1

      See identical proteins and their annotated locations for NP_033085.2

      Status: VALIDATED

      Source sequence(s)
      CR974462
      Consensus CDS
      CCDS28635.1
      UniProtKB/Swiss-Prot
      Q61193, Q9QUJ2
      UniProtKB/TrEMBL
      A0A068BD34
      Related
      ENSMUSP00000041082.10, ENSMUST00000047503.16
      Conserved Domains (3) summary
      cd00153
      Location:649 → 734
      RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
      smart00147
      Location:239 → 513
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:90 → 212
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

    RNA

    1. NR_177102.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      CR974462

    2. NR_177103.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      CR974462

    3. NR_177105.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      CR974462

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      34148813..34156661
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523910.2 → XP_006523973.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X1

      See identical proteins and their annotated locations for XP_006523973.1

      UniProtKB/TrEMBL
      A0A068BD34
      Conserved Domains (3) summary
      smart00147
      Location:126 → 400
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:1 → 99
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd17211
      Location:536 → 621
      RA_RGL2; Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like 2) and similar proteins

    RNA

    1. XR_385304.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61193.2 GenPept UniProtKB/Swiss-Prot:Q61193

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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