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    Rgl1 ral guanine nucleotide dissociation stimulator,-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 19731, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Rgl1provided by MGI
    Official Full Name
    ral guanine nucleotide dissociation stimulator,-like 1provided by MGI
    Primary source
    MGI:MGI:107484
    See related
    Ensembl:ENSMUSG00000026482 AllianceGenome:MGI:107484
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rgl; mKIAA0959
    Summary
    This gene encodes a member of the Ras-like (Ral) -selective guanine nucleotide exchange factor (RalGEF) family of small GTPase activators which function both as downstream effectors of activated Ras GTPase and as regulators of certain Ral GTPases in the RalGEF - Ral GTPase signaling pathway. The encoded protein, like other RalGEFs, has an N-terminal ras exchanger motif domain, a catalytic CDC25 homology domain, and a C-terminal ras binding domain that stimulates guanine nucleotide exchange when bound to a Ral GTPase. RalGEF family members bridge the Ras and Ral signaling pathways and are thought to play a role in oncogenic transformation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
    Expression
    Ubiquitous expression in kidney adult (RPKM 21.8), placenta adult (RPKM 12.6) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 G2- G3; 1 64.85 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (152392513..152642056, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (152516762..152766308, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene tRNA splicing endonuclease subunit 15 Neighboring gene collagen beta(1-O)galactosyltransferase 2 Neighboring gene basic transcription factor 3, pseudogene 14 Neighboring gene STARR-positive B cell enhancer ABC_E10046 Neighboring gene predicted gene, 51749 Neighboring gene STARR-seq mESC enhancer starr_02640 Neighboring gene STARR-seq mESC enhancer starr_02641 Neighboring gene STARR-positive B cell enhancer ABC_E5819 Neighboring gene STARR-positive B cell enhancer ABC_E2566 Neighboring gene ornithine decarboxylase, structural 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2567 Neighboring gene apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 4 Neighboring gene actin related protein 2/3 complex, subunit 5 Neighboring gene STARR-positive B cell enhancer ABC_E1566 Neighboring gene STARR-positive B cell enhancer ABC_E4358 Neighboring gene STARR-seq mESC enhancer starr_02648 Neighboring gene neutrophil cytosolic factor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ral small GTPase signaling and oncogenesis: More than just 15minutes of fame. Gentry LR, et al. Biochim Biophys Acta, 2014 Dec. PMID 25219551, Free PMC Article
    2. The RalGEF/Ral pathway: evaluating an intervention opportunity for Ras cancers. Cooper JM, et al. Enzymes, 2013. PMID 25034103
    3. RalGDS family members couple Ras to Ral signalling and that's not all. Ferro E, et al. Cell Signal, 2010 Dec. PMID 20478380
    4. ralGDS family members interact with the effector loop of ras p21. Kikuchi A, et al. Mol Cell Biol, 1994 Nov. PMID 7935463, Free PMC Article
    5. RalGDS-like factor (Rlf) is a novel Ras and Rap 1A-associating protein. Wolthuis RM, et al. Oncogene, 1996 Jul 18. PMID 8710374

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. rgl1 expression was strongly reduced by COX-2 deletion across all examined tissues.
      Title: COX-2 protects against atherosclerosis independently of local vascular prostacyclin: identification of COX-2 associated pathways implicate Rgl1 and lymphocyte networks.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0959

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ral guanine nucleotide dissociation stimulator-like 1
    Names
    ralGDS-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001346117.1 → NP_001333046.1  ral guanine nucleotide dissociation stimulator-like 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC118051, AC123613, AC123732, AK169109, BY245021, CN693385
      Consensus CDS
      CCDS87891.1
      UniProtKB/TrEMBL
      E9Q8M9
      Conserved Domains (3) summary
      smart00229
      Location:100 → 231
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:263 → 532
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd17210
      Location:682 → 768
      RA_RGL; Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1) and similar proteins

    2. NM_001346118.1 → NP_001333047.1  ral guanine nucleotide dissociation stimulator-like 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC118051, AC123613, AC123732, AK169109, BY245021, CN693385
      Consensus CDS
      CCDS87891.1
      UniProtKB/TrEMBL
      E9Q8M9
      Related
      ENSMUSP00000107490.2, ENSMUST00000111859.8
      Conserved Domains (3) summary
      smart00229
      Location:100 → 231
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:263 → 532
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd17210
      Location:682 → 768
      RA_RGL; Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1) and similar proteins

    3. NM_001346119.1 → NP_001333048.1  ral guanine nucleotide dissociation stimulator-like 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC118051, AC123613, AC123732, AK169109, BY245021, CN693385
      Consensus CDS
      CCDS87890.1
      UniProtKB/TrEMBL
      E9Q8N0
      Related
      ENSMUSP00000107488.2, ENSMUST00000111857.3
      Conserved Domains (3) summary
      smart00229
      Location:63 → 194
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:226 → 495
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd17210
      Location:645 → 731
      RA_RGL; Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1) and similar proteins

    4. NM_001420489.1 → NP_001407418.1  ral guanine nucleotide dissociation stimulator-like 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC118051, AC123613, AC123732
      UniProtKB/TrEMBL
      E9Q8N0

    5. NM_001420490.1 → NP_001407419.1  ral guanine nucleotide dissociation stimulator-like 1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC118051, AC123732

    6. NM_001420491.1 → NP_001407420.1  ral guanine nucleotide dissociation stimulator-like 1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC118051, AC123613, AC123732

    7. NM_001420492.1 → NP_001407421.1  ral guanine nucleotide dissociation stimulator-like 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC118051, AC123732

    8. NM_016846.5 → NP_058542.2  ral guanine nucleotide dissociation stimulator-like 1 isoform 3

      See identical proteins and their annotated locations for NP_058542.2

      Status: REVIEWED

      Source sequence(s)
      AC118051, AC123732
      Consensus CDS
      CCDS15365.1
      UniProtKB/Swiss-Prot
      Q60695, Q8VD09
      Related
      ENSMUSP00000027760.8, ENSMUST00000027760.14
      Conserved Domains (3) summary
      cd00153
      Location:648 → 733
      RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
      smart00229
      Location:65 → 196
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:228 → 497
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      152392513..152642056 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162813.1 → XP_036018706.1  ral guanine nucleotide dissociation stimulator-like 1 isoform X1

      UniProtKB/TrEMBL
      E9Q8N0
      Conserved Domains (3) summary
      smart00229
      Location:63 → 194
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:226 → 495
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd17210
      Location:645 → 731
      RA_RGL; Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1) and similar proteins

    2. XM_006529268.5 → XP_006529331.1  ral guanine nucleotide dissociation stimulator-like 1 isoform X3

      Conserved Domains (3) summary
      smart00229
      Location:20 → 151
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:183 → 452
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd17210
      Location:602 → 688
      RA_RGL; Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1) and similar proteins

    3. XM_006529267.5 → XP_006529330.1  ral guanine nucleotide dissociation stimulator-like 1 isoform X2

      Conserved Domains (2) summary
      cd00155
      Location:51 → 320
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd17210
      Location:470 → 556
      RA_RGL; Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q60695.2 GenPept UniProtKB/Swiss-Prot:Q60695

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