Rest RE1-silencing transcription factor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Restprovided by MGI
Official Full Name: RE1-silencing transcription factorprovided by MGI
Primary source: MGI:MGI:104897
See related: Ensembl:ENSMUSG00000029249 AllianceGenome:MGI:104897
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NRSF; REST4; 2610008J04Rik
Summary: Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II core promoter sequence-specific DNA binding activity; and identical protein binding activity. Involved in several processes, including auditory receptor cell stereocilium organization; regulation of gene expression; and regulation of neuron differentiation. Acts upstream of or within hematopoietic progenitor cell differentiation; negative regulation of neurogenesis; and regulation of gene expression. Located in cytosol and nucleus. Part of transcription repressor complex. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and peripheral nervous system ganglion. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 27; gingival fibromatosis 5; and nephroblastoma. Orthologous to human REST (RE1 silencing transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 7.4), limb E14.5 (RPKM 7.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 C3.3; 5 41.61 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (77413273..77434279)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (77265494..77286432)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ablation of placental REST deregulates fetal brain metabolism and impacts gene expression of the offspring brain at the postnatal and adult stages.
Title: Ablation of placental REST deregulates fetal brain metabolism and impacts gene expression of the offspring brain at the postnatal and adult stages.
A neurodegeneration checkpoint mediated by REST protects against the onset of Alzheimer's disease.
Title: A neurodegeneration checkpoint mediated by REST protects against the onset of Alzheimer's disease.
MicroRNA biogenesis machinery activation and lncRNA and REST overexpression as neuroprotective responses to fight inflammation in the hippocampus.
Title: MicroRNA biogenesis machinery activation and lncRNA and REST overexpression as neuroprotective responses to fight inflammation in the hippocampus.
NRSF regulates age-dependently cognitive ability and its conditional knockout in APP/PS1 mice moderately alters AD-like pathology.
Title: NRSF regulates age-dependently cognitive ability and its conditional knockout in APP/PS1 mice moderately alters AD-like pathology.
Aberrant Expression of Rest4 Gene in Low-Functioning Pancreatic Beta Cell Line.
Title: Aberrant Expression of Rest4 Gene in Low-Functioning Pancreatic Beta Cell Line.
CRISPR/Cas9-based genome-wide screening of the deubiquitinase subfamily identifies USP3 as a protein stabilizer of REST blocking neuronal differentiation and promotes neuroblastoma tumorigenesis.
Title: CRISPR/Cas9-based genome-wide screening of the deubiquitinase subfamily identifies USP3 as a protein stabilizer of REST blocking neuronal differentiation and promotes neuroblastoma tumorigenesis.
Loss of the repressor REST affects progesterone receptor function and promotes uterine leiomyoma pathogenesis.
Title: Loss of the repressor REST affects progesterone receptor function and promotes uterine leiomyoma pathogenesis.
PGC-1alpha4 Interacts with REST to Upregulate Neuronal Genes and Augment Energy Consumption in Developing Cardiomyocytes.
Title: PGC-1α4 Interacts with REST to Upregulate Neuronal Genes and Augment Energy Consumption in Developing Cardiomyocytes.
Repressor element 1-silencing transcription factor deficiency yields profound hearing loss through Kv7.4 channel upsurge in auditory neurons and hair cells.
Title: Repressor element 1-silencing transcription factor deficiency yields profound hearing loss through K(v)7.4 channel upsurge in auditory neurons and hair cells.
Deletion of RE1-silencing transcription factor in striatal astrocytes exacerbates manganese-induced neurotoxicity in mice.
Title: Deletion of RE1-silencing transcription factor in striatal astrocytes exacerbates manganese-induced neurotoxicity in mice.

Submit: New GeneRIF Correction See all GeneRIFs (136)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (16) 1 citation
Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Rest (e-PCR), detects polymorphism
- UniSTS:498725

Rest (e-PCR), detects polymorphism
- UniSTS:498726

NoName (e-PCR)
- UniSTS:237123

NoName (e-PCR)
- UniSTS:237124

RH125678 (e-PCR)
- UniSTS:162458

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II core promoter sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in auditory receptor cell stereocilium organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiac muscle cell myoblast differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to electrical stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucocorticoid stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to stress	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in detection of mechanical stimulus involved in sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in modification of synaptic structure	ISO Inferred from Sequence Orthology more info
involved_in negative regulation by host of viral transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of aldosterone biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of amniotic stem cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of calcium ion-dependent exocytosis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cortisol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of dense core granule biogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mesenchymal stem cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of miRNA transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neurogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription regulatory region DNA binding	IDA Inferred from Direct Assay more info	PubMed
involved_in nervous system process	ISO Inferred from Sequence Orthology more info
involved_in neuromuscular process controlling balance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuronal stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of programmed cell death	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stem cell population maintenance	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of alternative mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in response to ischemia	ISO Inferred from Sequence Orthology more info
involved_in somatic stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of chromatin	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of transcription repressor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription repressor complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription repressor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: RE1-silencing transcription factor

Names: neural-restrictive silencer factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011263.2 → NP_035393.2 RE1-silencing transcription factor

See identical proteins and their annotated locations for NP_035393.2

Status: VALIDATED

Source sequence(s)

AI121875, AK004945, BC127065, BE132774

Consensus CDS

CCDS19372.1

UniProtKB/Swiss-Prot

A0JNY8, Q155C6, Q3U0W0, Q4VAD6, Q8VIG1, Q9CW43

Related

ENSMUSP00000079231.6, ENSMUST00000080359.12

Conserved Domains (4) summary

PRK12323
Location:607 → 776

PRK12323; DNA polymerase III subunit gamma/tau

sd00017
Location:273 → 293

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:313 → 338

zf-H2C2_2; Zinc-finger double domain

pfam13909
Location:299 → 323

zf-H2C2_5; C2H2-type zinc-finger domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

77413273..77434279

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036164926.1 → XP_036020819.1 RE1-silencing transcription factor isoform X2

UniProtKB/TrEMBL

F8V330

Conserved Domains (3) summary

sd00017
Location:245 → 265

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:285 → 310

zf-H2C2_2; Zinc-finger double domain

pfam13909
Location:299 → 322

zf-H2C2_5; C2H2-type zinc-finger domain
XM_006534842.5 → XP_006534905.1 RE1-silencing transcription factor isoform X1

See identical proteins and their annotated locations for XP_006534905.1

UniProtKB/Swiss-Prot

A0JNY8, Q155C6, Q3U0W0, Q4VAD6, Q8VIG1, Q9CW43

Related

ENSMUSP00000109076.2, ENSMUST00000113449.2

Conserved Domains (4) summary

PRK12323
Location:607 → 776

PRK12323; DNA polymerase III subunit gamma/tau

sd00017
Location:273 → 293

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:313 → 338

zf-H2C2_2; Zinc-finger double domain

pfam13909
Location:299 → 323

zf-H2C2_5; C2H2-type zinc-finger domain