Reg3g regenerating islet-derived 3 gamma [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Reg3gprovided by MGI
Official Full Name: regenerating islet-derived 3 gammaprovided by MGI
Primary source: MGI:MGI:109406
See related: Ensembl:ENSMUSG00000030017 AllianceGenome:MGI:109406
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: REG-3-gamma; reg III-gamma
Summary: This gene encodes a C-type lectin that demonstrates bactericidal activity. This gene is predominantly expressed in the distal small intestine where the encoded protein undergoes proteolytic processing by trypsin. Mice lacking the encoded protein exhibit altered mucus distribution, increased bacterial contact with the epithelium, and elevated inflammatory markers in the ileum, and low-grade inflammation. [provided by RefSeq, Jun 2016]
Expression: Restricted expression toward large intestine adult (RPKM 6323.4) See more
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Genomic context

Location:: 6 C3; 6 34.78 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (78443252..78445857, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (78466269..78468874, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Immune cell-intrinsic Ah receptor facilitates the expression of antimicrobial REG3G in the small intestine.
Title: Immune cell-intrinsic Ah receptor facilitates the expression of antimicrobial REG3G in the small intestine.
Reg3gamma: current understanding and future therapeutic opportunities in metabolic disease.
Title: Reg3γ: current understanding and future therapeutic opportunities in metabolic disease.
Ruminococcus gnavus and Limosilactobacillus reuteri Regulate Reg3gamma Expression through Multiple Pathways.
Title: Ruminococcus gnavus and Limosilactobacillus reuteri Regulate Reg3γ Expression through Multiple Pathways.
Changes in gut microbiome correlate with intestinal barrier dysfunction and inflammation following a 3-day ethanol exposure in aged mice.
Title: Changes in gut microbiome correlate with intestinal barrier dysfunction and inflammation following a 3-day ethanol exposure in aged mice.
Nociceptor-derived Reg3gamma prevents endotoxic death by targeting kynurenine pathway in microglia.
Title: Nociceptor-derived Reg3γ prevents endotoxic death by targeting kynurenine pathway in microglia.
Temporal overexpression of IL-22 and Reg3gamma differentially impacts the severity of experimental autoimmune encephalomyelitis.
Title: Temporal overexpression of IL-22 and Reg3γ differentially impacts the severity of experimental autoimmune encephalomyelitis.
P. gingivalis Lipopolysaccharide Stimulates the Upregulated Expression of the Pancreatic Cancer-Related Genes Regenerating Islet-Derived 3 A/G in Mouse Pancreas.
Title: P. gingivalis Lipopolysaccharide Stimulates the Upregulated Expression of the Pancreatic Cancer-Related Genes Regenerating Islet-Derived 3 A/G in Mouse Pancreas.
Intestinal microbiota transplantation reveals the role of microbiota in dietary regulation of RegIIIbeta and RegIIIgamma expression in mouse intestine.
Title: Intestinal microbiota transplantation reveals the role of microbiota in dietary regulation of RegIIIβ and RegIIIγ expression in mouse intestine.
Reg3g expression was induced in the small intestines of mice by oral administration of Lactobacillus delbrueckii subsp. bulgaricus 2038 and Streptococcus thermophilus 1131 via production of the cytokines IL-23 and IL-22.
Title: Lactobacillus delbrueckii subsp. bulgaricus 2038 and Streptococcus thermophilus 1131 Induce the Expression of the REG3 Family in the Small Intestine of Mice via the Stimulation of Dendritic Cells and Type 3 Innate Lymphoid Cells.
Findings indicate that regenerating islet-derived 3 gamma (Reg3gamma) staining quantified through image analysis showed a time- and dose-response in cerulein-treated mice and rats.
Title: Detection of Reg3γ by Immunohistochemistry in Cerulein-Induced Model of Acute Pancreatic Injury in Mice and Rats.

Submit: New GeneRIF Correction See all GeneRIFs (28)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

D63361 (e-PCR)
- UniSTS:159523

Reg3g (e-PCR), detects polymorphism
- UniSTS:499109

AI449515 (e-PCR)
- UniSTS:179397

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables hormone activity	IDA Inferred from Direct Assay more info	PubMed
enables hormone activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oligosaccharide binding	IBA Inferred from Biological aspect of Ancestor more info
enables oligosaccharide binding	IDA Inferred from Direct Assay more info	PubMed
enables oligosaccharide binding	ISO Inferred from Sequence Orthology more info
enables peptidoglycan binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptidoglycan binding	IDA Inferred from Direct Assay more info	PubMed
enables peptidoglycan binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in MyD88-dependent toll-like receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within acute-phase response	IEA Inferred from Electronic Annotation more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IBA Inferred from Biological aspect of Ancestor more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to Gram-negative bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to Gram-positive bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to Gram-positive bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of inflammatory response to wounding	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of keratinocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of detection of glucose	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of keratinocyte proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of wound healing	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
involved_in response to peptide hormone	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to symbiotic bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in response to wounding	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: regenerating islet-derived protein 3-gamma

Names: generating islet-derived, mouse homolog 3 gamma; pancreatitis-associated protein 3; regenerating islet-derived protein III-gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011260.2 → NP_035390.1 regenerating islet-derived protein 3-gamma preproprotein

See identical proteins and their annotated locations for NP_035390.1

Status: REVIEWED

Source sequence(s)

BF020649, D63361

Consensus CDS

CCDS20258.1

UniProtKB/Swiss-Prot

O09049

UniProtKB/TrEMBL

Q545I1

Related

ENSMUSP00000032089.3, ENSMUST00000032089.3

Conserved Domains (1) summary

cd03594
Location:40 → 172

CLECT_REG-1_like; C-type lectin-like domain (CTLD) of the type found in Human REG-1 (lithostathine), REG-4, and avian eggshell-specific proteins: ansocalcin, structhiocalcin-1(SCA-1), and -2(SCA-2)