Rdh5 retinol dehydrogenase 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rdh5provided by MGI
Official Full Name: retinol dehydrogenase 5provided by MGI
Primary source: MGI:MGI:1201412
See related: Ensembl:ENSMUSG00000025350 AllianceGenome:MGI:1201412
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RDH4; cRDH; 9-cis
Summary: Enables NAD-retinol dehydrogenase activity. Involved in retinoid metabolic process. Located in endoplasmic reticulum lumen. Is expressed in several structures, including central nervous system; embryo ectoderm; genitourinary system; gut; and sensory organ. Human ortholog(s) of this gene implicated in fundus albipunctatus and night blindness. Orthologous to human RDH5 (retinol dehydrogenase 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in liver adult (RPKM 27.1), duodenum adult (RPKM 13.1) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D3; 10 77.19 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (128749457..128755906, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (128913588..128920037, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the longitudinal findings of spectral-domain optical coherence tomography (SD-OCT) in relation to the morphologic features in Rdh5 knockout (Rdh5-/-) mice, was investigated.
Title: A spectral-domain optical coherence tomographic analysis of Rdh5-/- mice retina.
cRDH may act essentially in the visual cycle but is redundant for catalyzing 9-cis-retinoic acid formation and 3 alpha-hydroxysteroid metabolism.
Title: Targeted disruption of the mouse cis-retinol dehydrogenase gene: visual and nonvisual functions.
RDH11 has a measurable role in regenerating the visual pigment by complementing RDH5 in retinal pigment epithelium.
Title: Delayed dark adaptation in 11-cis-retinol dehydrogenase-deficient mice: a role of RDH11 in visual processes in vivo.
The role of Rgr using rgr-/- single and rdh5-/-rgr-/- double knockout mice under a number of light conditions was studied; results suggest that RGR and RDH5 are likely to function in the retinoid cycle, although their role is not essential
Title: Evaluation of the role of the retinal G protein-coupled receptor (RGR) in the vertebrate retina in vivo.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC85795P2 (e-PCR)
- UniSTS:273492

AI987873 (e-PCR)
- UniSTS:180128

Rdh5 (e-PCR), detects polymorphism
- UniSTS:186537

Rdh5 (e-PCR), detects polymorphism
- UniSTS:144336

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 11-cis-retinol dehydrogenase	IEA Inferred from Electronic Annotation more info
enables all-trans-retinol dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables all-trans-retinol dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables all-trans-retinol dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables androstan-3-alpha,17-beta-diol dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables androsterone dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to stimulus	IEA Inferred from Electronic Annotation more info
involved_in retinoid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in retinoid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in retinoid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in steroid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in steroid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within visual perception	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell body	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum lumen	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum lumen	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: retinol dehydrogenase 5

Names: 11-cis RDH; 11-cis RoDH; 11-cis retinol dehydrogenase; 9-cis-retinol dehydrogenase; cis-retinol dehydrogenase; retinol dehydrogenase type 5

NP_001345456.1

EC 1.1.1.209

EC 1.1.1.315

EC 1.1.1.53

NP_598767.1

EC 1.1.1.209

EC 1.1.1.315

EC 1.1.1.53

XP_006513448.1

EC 1.1.1.209

EC 1.1.1.315

EC 1.1.1.53

XP_036011599.1

EC 1.1.1.209

EC 1.1.1.315

EC 1.1.1.53

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001358527.2 → NP_001345456.1 retinol dehydrogenase 5 isoform b

Status: VALIDATED

Source sequence(s)

AC122380

Consensus CDS

CCDS24298.1

UniProtKB/Swiss-Prot

O55240

Conserved Domains (1) summary

cl25409
Location:30 → 306

SDR; Short-chain dehydrogenases/reductases (SDR)
NM_001428782.1 → NP_001415711.1 retinol dehydrogenase 5 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (3), as well as variant 4, encodes the longest isoform (a).

Source sequence(s)

AC122380
NM_001428783.1 → NP_001415712.1 retinol dehydrogenase 5 isoform a

Status: VALIDATED

Source sequence(s)

AC122380
NM_001428784.1 → NP_001415713.1 retinol dehydrogenase 5 isoform c

Status: VALIDATED

Source sequence(s)

AC122380
NM_134006.6 → NP_598767.1 retinol dehydrogenase 5 isoform b

See identical proteins and their annotated locations for NP_598767.1

Status: VALIDATED

Description

Transcript Variant: This variant (1), as well as variant 2, encodes isoform b.

Source sequence(s)

AC122380

Consensus CDS

CCDS24298.1

UniProtKB/Swiss-Prot

O55240

Related

ENSMUSP00000026406.8, ENSMUST00000026406.14

Conserved Domains (1) summary

cl25409
Location:30 → 306

SDR; Short-chain dehydrogenases/reductases (SDR)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

128749457..128755906 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006513385.4 → XP_006513448.1 retinol dehydrogenase 5 isoform X1

See identical proteins and their annotated locations for XP_006513448.1

Conserved Domains (1) summary

cl21454
Location:30 → 308

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_036155706.1 → XP_036011599.1 retinol dehydrogenase 5 isoform X1

Conserved Domains (1) summary

cl21454
Location:30 → 308

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins