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    Rbpms RNA binding protein gene with multiple splicing [ Mus musculus (house mouse) ]

    Gene ID: 19663, updated on 16-Apr-2024

    Summary

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    Official Symbol
    Rbpmsprovided by MGI
    Official Full Name
    RNA binding protein gene with multiple splicingprovided by MGI
    Primary source
    MGI:MGI:1334446
    See related
    Ensembl:ENSMUSG00000031586 AllianceGenome:MGI:1334446
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RBP-MS; hermes; 2010300K22Rik; 2700019M19Rik
    Summary
    Predicted to enable RNA binding activity; protein homodimerization activity; and transcription coactivator activity. Predicted to be involved in positive regulation of SMAD protein signal transduction; positive regulation of pathway-restricted SMAD protein phosphorylation; and response to oxidative stress. Predicted to be located in cytoplasmic stress granule; cytosol; and nucleoplasm. Is expressed in several structures, including central nervous system; gut; heart; retina; and urinary system. Orthologous to human RBPMS (RNA binding protein, mRNA processing factor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in ovary adult (RPKM 24.2), bladder adult (RPKM 22.5) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rbpms in Genome Data Viewer
    Location:
    8 A4; 8 20.85 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (34272671..34419925, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (33782643..33929922, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700104B16 gene Neighboring gene general transcription factor II E, polypeptide 2 (beta subunit) Neighboring gene STARR-seq mESC enhancer starr_21117 Neighboring gene small integral membrane protein 18 Neighboring gene STARR-seq mESC enhancer starr_21127 Neighboring gene VISTA enhancer mm70 Neighboring gene STARR-seq mESC enhancer starr_21144 Neighboring gene STARR-seq mESC enhancer starr_21145 Neighboring gene predicted gene, 51528 Neighboring gene STARR-seq mESC enhancer starr_21150 Neighboring gene STARR-positive B cell enhancer mm9_chr8:35078702-35079003 Neighboring gene predicted gene, 33588 Neighboring gene STARR-seq mESC enhancer starr_21156 Neighboring gene predicted gene, 39157 Neighboring gene predicted gene, 57792

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of Sgo1 expression in developing and adult mouse. Song AT, et al. Gene Expr Patterns, 2017 Nov. PMID 28465207
    2. Diversification of multipotential postmitotic mouse retinal ganglion cell precursors into discrete types. Shekhar K, et al. Elife, 2022 Feb 22. PMID 35191836, Free PMC Article
    3. Maf1 regulates axonal regeneration of retinal ganglion cells after injury. Chen D, et al. Exp Neurol, 2022 Feb. PMID 34902358
    4. The RNA-binding protein gene, hermes, is expressed at high levels in the developing heart. Gerber WV, et al. Mech Dev, 1999 Jan. PMID 10096065
    5. Interaction and colocalization of HERMES/RBPMS with NonO, PSF, and G3BP1 in neuronal cytoplasmic RNP granules in mouse retinal line cells. Furukawa MT, et al. Genes Cells, 2015 Apr. PMID 25651939

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Comparison of Brn3a and RBPMS Labeling to Assess Retinal Ganglion Cell Loss During Aging and in a Model of Optic Neuropathy.
      Title: Comparison of Brn3a and RBPMS Labeling to Assess Retinal Ganglion Cell Loss During Aging and in a Model of Optic Neuropathy.
    2. RBPMS regulates cardiomyocyte contraction and cardiac function through RNA alternative splicing.
      Title: RBPMS regulates cardiomyocyte contraction and cardiac function through RNA alternative splicing.
    3. RBPMS is an RNA-binding protein that mediates cardiomyocyte binucleation and cardiovascular development.
      Title: RBPMS is an RNA-binding protein that mediates cardiomyocyte binucleation and cardiovascular development.
    4. Cytoplasmic granule containing HERMES, NonO, PSF, and G3BP1 is a neuronal RNA-protein granule that is transported in neurites during retinal differentiation.
      Title: Interaction and colocalization of HERMES/RBPMS with NonO, PSF, and G3BP1 in neuronal cytoplasmic RNP granules in mouse retinal line cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA CDS binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pre-mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pre-mRNA intronic binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in SMAD protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding protein with multiple splicing
    Names
    HEart, RRM Expressed Sequence
    RNA-binding protein with multiple splicing (RBP-MS)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042674.2 → NP_001036139.1  RNA-binding protein with multiple splicing isoform 1

      See identical proteins and their annotated locations for NP_001036139.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR, compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).
      Source sequence(s)
      AC162523, AK003434, AK041118
      Consensus CDS
      CCDS40317.1
      UniProtKB/Swiss-Prot
      Q78HG1, Q9CPU5, Q9WVB0
      Related
      ENSMUSP00000055813.5, ENSMUST00000053251.12
      Conserved Domains (1) summary
      cd12682
      Location:23 → 98
      RRM_RBPMS; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing (RBP-MS)

    2. NM_001042675.2 → NP_001036140.1  RNA-binding protein with multiple splicing isoform 3

      See identical proteins and their annotated locations for NP_001036140.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks several exons and includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform 3 which is longer and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC162523, AK012265
      Consensus CDS
      CCDS40318.1
      UniProtKB/Swiss-Prot
      Q9WVB0
      Related
      ENSMUSP00000033995.7, ENSMUST00000033995.14
      Conserved Domains (1) summary
      cd12682
      Location:23 → 98
      RRM_RBPMS; RNA recognition motif (RRM) found in vertebrate RNA-binding protein with multiple splicing (RBP-MS)

    3. NM_001286168.1 → NP_001273097.1  RNA-binding protein with multiple splicing isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. This results in a shorter protein (isoform 4) with a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC162523, AK003434, AK079238
      Consensus CDS
      CCDS72112.1
      UniProtKB/TrEMBL
      Q8C586, T1ECW4
      Related
      ENSMUSP00000033994.9, ENSMUST00000033994.15
      Conserved Domains (1) summary
      cd12682
      Location:23 → 98
      RRM_RBPMS; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing (RBP-MS)

    4. NM_019733.3 → NP_062707.1  RNA-binding protein with multiple splicing isoform 1

      See identical proteins and their annotated locations for NP_062707.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC162523, AK003434, AK041118, AK079238
      Consensus CDS
      CCDS40317.1
      UniProtKB/Swiss-Prot
      Q78HG1, Q9CPU5, Q9WVB0
      Related
      ENSMUSP00000140387.2, ENSMUST00000191473.7
      Conserved Domains (1) summary
      cd12682
      Location:23 → 98
      RRM_RBPMS; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing (RBP-MS)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      34272671..34419925 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509037.4 → XP_006509100.3  RNA-binding protein with multiple splicing isoform X4

      Conserved Domains (1) summary
      cd12682
      Location:40 → 115
      RRM_RBPMS; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing (RBP-MS)

    2. XM_006509035.5 → XP_006509098.1  RNA-binding protein with multiple splicing isoform X2

      Conserved Domains (1) summary
      cd12682
      Location:23 → 98
      RRM_RBPMS; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing (RBP-MS)

    3. XM_006509034.5 → XP_006509097.1  RNA-binding protein with multiple splicing isoform X1

      Conserved Domains (1) summary
      cd12682
      Location:40 → 115
      RRM_RBPMS; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing (RBP-MS)

    4. XM_036153838.1 → XP_036009731.1  RNA-binding protein with multiple splicing isoform X3

      Conserved Domains (1) summary
      cd12682
      Location:40 → 115
      RRM_RBPMS; RNA recognition motif (RRM) found in vertebrate RNA-binding protein with multiple splicing (RBP-MS)

    RNA

    1. XR_378783.4 RNA Sequence

    2. XR_378781.4 RNA Sequence

    3. XR_378782.3 RNA Sequence

    4. XR_378780.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WVB0.2 GenPept UniProtKB/Swiss-Prot:Q9WVB0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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