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    Rbm3 RNA binding motif (RNP1, RRM) protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 19652, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Rbm3provided by MGI
    Official Full Name
    RNA binding motif (RNP1, RRM) protein 3provided by MGI
    Primary source
    MGI:MGI:1099460
    See related
    Ensembl:ENSMUSG00000031167 AllianceGenome:MGI:1099460
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2600016C11Rik
    Summary
    Enables ribosomal large subunit binding activity. Involved in regulation of translation. Acts upstream of or within production of miRNAs involved in gene silencing by miRNA; response to cold; and translation. Predicted to be located in cytoplasm; dendrite; and nucleoplasm. Predicted to be part of spliceosomal complex. Is expressed in several structures, including central nervous system; ovary; and sensory organ. Orthologous to human RBM3 (RNA binding motif protein 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 50.1), liver E14 (RPKM 45.8) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rbm3 in Genome Data Viewer
    Location:
    X A1.1; X 3.68 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (8005214..8012119, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (8138975..8145880, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene proteasome (prosome, macropain) subunit, beta type 7 pseudogene Neighboring gene proteasome (prosome, macropain) subunit, beta type 7, pseudogene 2 Neighboring gene STARR-positive B cell enhancer ABC_E7686 Neighboring gene WD repeat domain 13 Neighboring gene RNA binding motif protein 3, opposite strand Neighboring gene TBC1 domain family, member 25 Neighboring gene STARR-seq mESC enhancer starr_46689 Neighboring gene STARR-seq mESC enhancer starr_46690 Neighboring gene EBP cholestenol delta-isomerase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The transcript interactome of skeletal muscle RNA binding protein motif 3 (RBM3). Hettinger ZR, et al. Physiol Rep, 2023 Feb. PMID 36750123, Free PMC Article
    2. RNA binding motif protein 3 (RBM3) promotes protein kinase B (AKT) activation to enhance glucose metabolism and reduce apoptosis in skeletal muscle of mice under acute cold exposure. Liu Y, et al. Cell Stress Chaperones, 2022 Nov. PMID 36149580, Free PMC Article
    3. RBM3 Increases Cell Survival but Disrupts Tight Junction of Microvascular Endothelial Cells in Acute Lung Injury. Feng J, et al. J Surg Res, 2021 May. PMID 33460967
    4. The Expression of the Cold Shock Protein RNA Binding Motif Protein 3 is Transcriptionally Responsive to Organ Temperature in Mice. Ushio A, et al. Protein Pept Lett, 2021. PMID 32972335
    5. The RNA-Binding Protein RBM3 Promotes Neural Stem Cell (NSC) Proliferation Under Hypoxia. Yan J, et al. Front Cell Dev Biol, 2019. PMID 31824945, Free PMC Article

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RBM3 Accelerates Wound Healing of Skin in Diabetes through ERK1/2 Signaling.
      Title: RBM3 Accelerates Wound Healing of Skin in Diabetes through ERK1/2 Signaling.
    2. Study on the protective effect of RNA-binding motif protein 3 in mild hypothermia oxygen-glucose deprivation/reoxygenation cell model.
      Title: Study on the protective effect of RNA-binding motif protein 3 in mild hypothermia oxygen-glucose deprivation/reoxygenation cell model.
    3. Chronic social stress blunts core body temperature and molecular rhythms of Rbm3 and Cirbp in mouse lateral habenula.
      Title: Chronic social stress blunts core body temperature and molecular rhythms of Rbm3 and Cirbp in mouse lateral habenula.
    4. RBM3 is associated with acute lung injury in septic mice and patients via the NF-kappaB/NLRP3 pathway.
      Title: RBM3 is associated with acute lung injury in septic mice and patients via the NF-κB/NLRP3 pathway.
    5. The transcript interactome of skeletal muscle RNA binding protein motif 3 (RBM3).
      Title: The transcript interactome of skeletal muscle RNA binding protein motif 3 (RBM3).
    6. RNA binding motif protein 3 (RBM3) promotes protein kinase B (AKT) activation to enhance glucose metabolism and reduce apoptosis in skeletal muscle of mice under acute cold exposure.
      Title: RNA binding motif protein 3 (RBM3) promotes protein kinase B (AKT) activation to enhance glucose metabolism and reduce apoptosis in skeletal muscle of mice under acute cold exposure.
    7. RNA-binding protein RBM3 intrinsically suppresses lung innate lymphoid cell activation and inflammation partially through CysLT1R.
      Title: RNA-binding protein RBM3 intrinsically suppresses lung innate lymphoid cell activation and inflammation partially through CysLT1R.
    8. Skeletal muscle RBM3 expression is associated with extended lifespan in Ames Dwarf and calorie restricted mice.
      Title: Skeletal muscle RBM3 expression is associated with extended lifespan in Ames Dwarf and calorie restricted mice.
    9. TrkB signaling regulates the cold-shock protein RBM3-mediated neuroprotection.
      Title: TrkB signaling regulates the cold-shock protein RBM3-mediated neuroprotection.
    10. RBM3 Increases Cell Survival but Disrupts Tight Junction of Microvascular Endothelial Cells in Acute Lung Injury.
      Title: RBM3 Increases Cell Survival but Disrupts Tight Junction of Microvascular Endothelial Cells in Acute Lung Injury.
    Submit: New GeneRIF Correction See all GeneRIFs (24)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (3)  1 citation
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC118410

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosomal large subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosomal large subunit binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within miRNA processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cold IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding protein 3
    Names
    RNA binding motif protein 3
    putative RNA-binding protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166409.2 → NP_001159881.1  RNA-binding protein 3 isoform 1

      See identical proteins and their annotated locations for NP_001159881.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site and alternate terminal exon in the 3' UTR, compared to variant 1. Variants 1, 2, and 5 encode the same protein (isoform 1).
      Source sequence(s)
      AK133795, AL663032, BB050916, BC106176, CN696660
      Consensus CDS
      CCDS29987.1
      UniProtKB/TrEMBL
      Q8BG13
      Related
      ENSMUSP00000111280.4, ENSMUST00000115617.10
      Conserved Domains (1) summary
      cd12449
      Location:6 → 85
      RRM_CIRBP_RBM3; RNA recognition motif in cold inducible RNA binding protein (CIRBP), RNA binding motif protein 3 (RBM3) and similar proteins

    2. NM_001166410.2 → NP_001159882.1  RNA-binding protein 3 isoform 2

      See identical proteins and their annotated locations for NP_001159882.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region and alternate 3' terminal exon, compared to variant 1. The encoded protein (isoform 2) has a shorter protein, compared to isoform 1.
      Source sequence(s)
      AL663032, BB050916, BC106176
      Consensus CDS
      CCDS52988.1
      UniProtKB/Swiss-Prot
      O89086
      UniProtKB/TrEMBL
      Q545K5, Q5RJV3
      Related
      ENSMUSP00000111284.3, ENSMUST00000115621.9
      Conserved Domains (1) summary
      cd12449
      Location:6 → 85
      RRM_CIRBP_RBM3; RNA recognition motif in cold inducible RNA binding protein (CIRBP), RNA binding motif protein 3 (RBM3) and similar proteins

    3. NM_001166411.2 → NP_001159883.1  RNA-binding protein 3 isoform 2

      See identical proteins and their annotated locations for NP_001159883.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' coding region and differs in the 3' UTR, compared to variant 1. The encoded protein (isoform 2) has a shorter protein, compared to isoform 1.
      Source sequence(s)
      AK133795, AL663032, BB050916, BC106176
      Consensus CDS
      CCDS52988.1
      UniProtKB/Swiss-Prot
      O89086
      UniProtKB/TrEMBL
      Q545K5, Q5RJV3
      Related
      ENSMUSP00000111277.3, ENSMUST00000115615.9
      Conserved Domains (1) summary
      cd12449
      Location:6 → 85
      RRM_CIRBP_RBM3; RNA recognition motif in cold inducible RNA binding protein (CIRBP), RNA binding motif protein 3 (RBM3) and similar proteins

    4. NM_001293658.1 → NP_001280587.1  RNA-binding protein 3 isoform 1

      See identical proteins and their annotated locations for NP_001280587.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) contains an alternate terminal exon in the 3' UTR, compared to variant 1. Variants 1, 2, and 5 encode the same protein (isoform 1).
      Source sequence(s)
      AL663032, BB050916, BC086491, BC106176
      Consensus CDS
      CCDS29987.1
      UniProtKB/TrEMBL
      Q8BG13
      Related
      ENSMUSP00000111279.2, ENSMUST00000115616.8
      Conserved Domains (1) summary
      cd12449
      Location:6 → 85
      RRM_CIRBP_RBM3; RNA recognition motif in cold inducible RNA binding protein (CIRBP), RNA binding motif protein 3 (RBM3) and similar proteins

    5. NM_016809.6 → NP_058089.2  RNA-binding protein 3 isoform 1

      See identical proteins and their annotated locations for NP_058089.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer protein (isoform 1). Variants 1, 2, and 5 encode the same protein (isoform 1).
      Source sequence(s)
      AK011224, AK049575, AL663032, BC106176
      Consensus CDS
      CCDS29987.1
      UniProtKB/TrEMBL
      Q8BG13
      Related
      ENSMUSP00000038964.4, ENSMUST00000040010.10
      Conserved Domains (1) summary
      cd12449
      Location:6 → 85
      RRM_CIRBP_RBM3; RNA recognition motif in cold inducible RNA binding protein (CIRBP), RNA binding motif protein 3 (RBM3) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      8005214..8012119 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O89086.1 GenPept UniProtKB/Swiss-Prot:O89086

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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