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    Zzef1 zinc finger, ZZ-type with EF hand domain 1 [ Mus musculus (house mouse) ]

    Gene ID: 195018, updated on 21-Apr-2024

    Summary

    Official Symbol
    Zzef1provided by MGI
    Official Full Name
    zinc finger, ZZ-type with EF hand domain 1provided by MGI
    Primary source
    MGI:MGI:2444286
    See related
    Ensembl:ENSMUSG00000055670 AllianceGenome:MGI:2444286
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NSPA; mKIAA0399; 8430405D05Rik; C130099L13Rik
    Summary
    Enables ubiquitin-like protein ligase activity. Acts upstream of or within several processes, including glutamatergic synaptic transmission; regulation of peptidyl-tyrosine phosphorylation; and visual learning. Located in cell surface; postsynapse; and presynaptic active zone. Is expressed in several structures, including adipose tissue; alimentary system; immune system; nervous system; and reproductive system. Orthologous to human ZZEF1 (zinc finger ZZ-type and EF-hand domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 16.1), small intestine adult (RPKM 15.6) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    Location:
    11 B4; 11 44.56 cM
    Exon count:
    56
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (72686976..72817946)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (72796150..72927120)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and FYVE domain containing 1 Neighboring gene predicted gene, 46287 Neighboring gene STARR-positive B cell enhancer ABC_E8424 Neighboring gene cytochrome b5 domain containing 2 Neighboring gene signal recognition particle receptor ('docking protein') pseudogene Neighboring gene predicted gene, 26121 Neighboring gene predicted gene, 34704 Neighboring gene predicted gene, 34793

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3) 
    • Endonuclease-mediated (1) 

    General gene information

    Markers

    Clone Names

    • MGC107545

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone reader activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables lysine-acetylated histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-like protein ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in presynaptic active zone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    zinc finger ZZ-type and EF-hand domain-containing protein 1
    Names
    KIAA0399-like protein human
    neuronal superface P antigen

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045536.2NP_001039001.1  zinc finger ZZ-type and EF-hand domain-containing protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL663082
      Consensus CDS
      CCDS36218.1
      UniProtKB/TrEMBL
      E9Q5W5
      Related
      ENSMUSP00000068790.6, ENSMUST00000069395.7
      Conserved Domains (5) summary
      cd08667
      Location:250380
      APC10-ZZEF1; APC10/DOC1-like domain of uncharacterized Zinc finger ZZ-type and EF-hand domain-containing protein 1 (ZZEF1) and homologs
      cd00051
      Location:94141
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd02249
      Location:18281875
      ZZ; Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...
      cd02343
      Location:17791826
      ZZ_EF; Zinc finger, ZZ type. Zinc finger present in proteins with an EF_hand motif. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
      cl00049
      Location:11191189
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    2. NM_001427298.1NP_001414227.1  zinc finger ZZ-type and EF-hand domain-containing protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL663082

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      72686976..72817946
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532601.4XP_006532664.1  zinc finger ZZ-type and EF-hand domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A140LJ04, E9Q5W5
      Related
      ENSMUSP00000147028.2, ENSMUST00000207107.2
      Conserved Domains (5) summary
      cd08667
      Location:250380
      APC10-ZZEF1; APC10/DOC1-like domain of uncharacterized Zinc finger ZZ-type and EF-hand domain-containing protein 1 (ZZEF1) and homologs
      cd00051
      Location:94141
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd02249
      Location:18281875
      ZZ; Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...
      cd02343
      Location:17791826
      ZZ_EF; Zinc finger, ZZ type. Zinc finger present in proteins with an EF_hand motif. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
      cl00049
      Location:11191189
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    2. XM_030245704.2XP_030101564.1  zinc finger ZZ-type and EF-hand domain-containing protein 1 isoform X5

      Conserved Domains (2) summary
      cd02249
      Location:444491
      ZZ; Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...
      cd02343
      Location:395442
      ZZ_EF; Zinc finger, ZZ type. Zinc finger present in proteins with an EF_hand motif. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
    3. XM_011248827.3XP_011247129.1  zinc finger ZZ-type and EF-hand domain-containing protein 1 isoform X3

      Conserved Domains (2) summary
      cd02249
      Location:590637
      ZZ; Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...
      cd02343
      Location:541588
      ZZ_EF; Zinc finger, ZZ type. Zinc finger present in proteins with an EF_hand motif. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
    4. XM_006532603.4XP_006532666.1  zinc finger ZZ-type and EF-hand domain-containing protein 1 isoform X4

      Conserved Domains (2) summary
      cd02249
      Location:444491
      ZZ; Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...
      cd02343
      Location:395442
      ZZ_EF; Zinc finger, ZZ type. Zinc finger present in proteins with an EF_hand motif. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.