Rimkla ribosomal modification protein rimK-like family member A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rimklaprovided by MGI
Official Full Name: ribosomal modification protein rimK-like family member Aprovided by MGI
Primary source: MGI:MGI:3040686
See related: Ensembl:ENSMUSG00000048899 AllianceGenome:MGI:3040686
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rimk; NAAGS; NAAGS-II; B930030J24
Summary: Enables N-acetyl-L-aspartate-L-glutamate ligase activity. Predicted to be involved in cellular protein modification process. Located in cytoplasm. Is expressed in several structures, including adrenal gland; central nervous system; genitourinary system; hemolymphoid system gland; and liver. Orthologous to human RIMKLA (ribosomal modification protein rimK like family member A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cerebellum adult (RPKM 8.9), CNS E18 (RPKM 6.8) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.1; 4 55.4 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (119322480..119349795, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (119465283..119492598, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ribosomal modification protein rimK-like family member A (Rimkla) gene is a NAAG synthetase (NAAGS-II), which synthesizes the N-acetylated tripeptide N-acetylaspartylglutamylglutamate (NAAG(2))
Title: N-acetylaspartylglutamate synthetase II synthesizes N-acetylaspartylglutamylglutamate.
Molecular identification of N-acetylaspartylglutamate synthase and beta-citrylglutamate synthase.
Title: Molecular identification of N-acetylaspartylglutamate synthase and beta-citrylglutamate synthase.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables N-acetyl-L-aspartate-L-glutamate ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-acetyl-L-aspartate-L-glutamate ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein modification process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: N-acetylaspartylglutamate synthase A

Names: N-acetylaspartyl-glutamate synthetase A; N-acetylaspartylglutamylglutamate synthase A; NAAG synthetase A; ribosomal protein S6 modification-like protein A

NP_808240.2

EC 6.3.2.41

EC 6.3.2.42

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.