Rasgrp2 RAS, guanyl releasing protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rasgrp2provided by MGI
Official Full Name: RAS, guanyl releasing protein 2provided by MGI
Primary source: MGI:MGI:1333849
See related: Ensembl:ENSMUSG00000032946 AllianceGenome:MGI:1333849
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CDC25L; Caldaggef1; CalDAG-GEFI
Summary: Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in cellular response to calcium ion and positive regulation of GTPase activity. Predicted to be located in cytosol and plasma membrane. Is expressed in brain. Used to study leukocyte adhesion deficiency 3. Human ortholog(s) of this gene implicated in platelet-type bleeding disorder 18. Orthologous to human RASGRP2 (RAS guanyl releasing protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in spleen adult (RPKM 41.2), thymus adult (RPKM 27.3) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 4.58 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (6449038..6465243)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (6398957..6415216)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CalDAG-GEFI mediates striatal cholinergic modulation of dendritic excitability, synaptic plasticity and psychomotor behaviors.
Title: CalDAG-GEFI mediates striatal cholinergic modulation of dendritic excitability, synaptic plasticity and psychomotor behaviors.
CalDAG-GEFI is critical for atherosclerotic plaque development in hypercholesterolemic Ldlr(-/-) mice because of its contribution to platelet-leukocyte aggregate formation and leukocyte recruitment to the lesion area.
Title: CalDAG-GEFI Deficiency Reduces Atherosclerotic Lesion Development in Mice.
(i) STIM1/SOCE is critical for procoagulant activity but not the proadhesive function of platelets; and (ii) at the site of vascular injury, STIM1 and CalDAG-GEFI are critical for the first wave of thrombin generation mediated by procoagulant platelets
Title: Relative contributions of stromal interaction molecule 1 and CalDAG-GEFI to calcium-dependent platelet activation and thrombosis.
we evaluated the contribution of CalDAG-GEFI to platelet activation in a model of immune-mediated thrombocytopenia and thrombosis syndromes
Title: CalDAG-GEFI deficiency protects mice in a novel model of Fcγ RIIA-mediated thrombosis and thrombocytopenia.
Studies indicate that CalDAG-GEFI mediates the rapid but reversible activation of integrin alphaIIbbeta3, and the adenosine diphosphate receptor P2Y12 facilitates delayed but sustained integrin activation.
Title: The kinetics of αIIbβ3 activation determines the size and stability of thrombi in mice: implications for antiplatelet therapy.
CalDAG-GEFI helps regulate neutrophil chemotaxis, independent of its established role in integrin activation, through a mechanism that involves actin cytoskeleton and cellular polarization.
Title: Integrin-independent role of CalDAG-GEFI in neutrophil chemotaxis.
In a brain-slice explant model of Huntington's disease, knock-down of CalDAG-GEFI expression rescues striatal neurons from pathology induced by transfection of polyglutamine-expanded Htt exon 1.
Title: CalDAG-GEFI down-regulation in the striatum as a neuroprotective change in Huntington's disease.
CalDAG-GEFI and PKC represent separate, but synergizing, pathways important for alphaIIbbeta3 activation in platelets activated through the PAR4 receptor.
Title: CalDAG-GEFI and protein kinase C represent alternative pathways leading to activation of integrin alphaIIbbeta3 in platelets.
CalDAG-GEFI regulated the activation of beta(1) and beta(3) integrins in platelets, and CalDAG-GEFI deficiency caused complete inhibition of arterial thrombus formation.
Title: Mice lacking the signaling molecule CalDAG-GEFI represent a model for leukocyte adhesion deficiency type III.
CalDAG-GEFI plays a role in inside-out signaling to alphaIIbbeta3
Title: Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (1) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

Rasgrp2 (e-PCR), detects polymorphism
- UniSTS:508520

RH131404 (e-PCR)
- UniSTS:214687

Rasgrp2 (e-PCR), detects polymorphism
- UniSTS:528305

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuron projection	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: RAS guanyl-releasing protein 2

Names: F25B3.3 kinase like protein; RAP 1A protein-specific guanine nucleotide exchange factor 1; calcium and DAG-regulated guanine nucleotide exchange factor I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001365062.1 → NP_001351991.1 RAS guanyl-releasing protein 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC167245

Consensus CDS

CCDS89325.1

UniProtKB/TrEMBL

D6RDD3

Related

ENSMUSP00000123036.2, ENSMUST00000139522.8

Conserved Domains (1) summary

smart00229
Location:7 → 121

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
NM_001365063.1 → NP_001351992.1 RAS guanyl-releasing protein 2 isoform 2

Status: VALIDATED

Source sequence(s)

BC051474, BE457673

Consensus CDS

CCDS89325.1

UniProtKB/TrEMBL

D6RDD3

Related

ENSMUSP00000109099.2, ENSMUST00000113471.3

Conserved Domains (1) summary

smart00229
Location:7 → 121

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
NM_001411231.1 → NP_001398160.1 RAS guanyl-releasing protein 2 isoform 1

Status: VALIDATED

Source sequence(s)

AC167245

UniProtKB/Swiss-Prot

O09004, Q80WC0, Q8BSC8, Q9QUG9
NM_001411232.1 → NP_001398161.1 RAS guanyl-releasing protein 2 isoform 1

Status: VALIDATED

Source sequence(s)

AC167245

UniProtKB/Swiss-Prot

O09004, Q80WC0, Q8BSC8, Q9QUG9
NM_011242.4 → NP_035372.2 RAS guanyl-releasing protein 2 isoform 1

See identical proteins and their annotated locations for NP_035372.2

Status: VALIDATED

Source sequence(s)

AC167245

Consensus CDS

CCDS37898.1

UniProtKB/Swiss-Prot

O09004, Q80WC0, Q8BSC8, Q9QUG9

Related

ENSMUSP00000129873.2, ENSMUST00000167240.8

Conserved Domains (4) summary

smart00147
Location:150 → 387

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:7 → 121

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd00029
Location:499 → 548

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00051
Location:430 → 481

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RNA

NR_157554.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

BE457673, BE655519, CJ058933

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

6449038..6465243

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030250784.1 → XP_030106644.1 RAS guanyl-releasing protein 2 isoform X2

Conserved Domains (4) summary

smart00147
Location:113 → 350

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:1 → 84

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd00029
Location:462 → 511

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00051
Location:393 → 444

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
XM_006531687.2 → XP_006531750.1 RAS guanyl-releasing protein 2 isoform X1

See identical proteins and their annotated locations for XP_006531750.1

UniProtKB/Swiss-Prot

O09004, Q80WC0, Q8BSC8, Q9QUG9

Conserved Domains (4) summary

smart00147
Location:150 → 387

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:7 → 121

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd00029
Location:499 → 548

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00051
Location:430 → 481

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
XM_006531691.3 → XP_006531754.1 RAS guanyl-releasing protein 2 isoform X1

See identical proteins and their annotated locations for XP_006531754.1

UniProtKB/Swiss-Prot

O09004, Q80WC0, Q8BSC8, Q9QUG9

Related

ENSMUSP00000109104.2, ENSMUST00000113476.8

Conserved Domains (4) summary

smart00147
Location:150 → 387

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:7 → 121

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd00029
Location:499 → 548

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00051
Location:430 → 481

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
XM_030250792.1 → XP_030106652.1 RAS guanyl-releasing protein 2 isoform X5

Conserved Domains (3) summary

smart00147
Location:5 → 242

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd00029
Location:354 → 403

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00051
Location:285 → 336

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
XM_030250788.2 → XP_030106648.1 RAS guanyl-releasing protein 2 isoform X5

Conserved Domains (3) summary

smart00147
Location:5 → 242

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd00029
Location:354 → 403

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00051
Location:285 → 336

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
XM_006531686.5 → XP_006531749.1 RAS guanyl-releasing protein 2 isoform X1

See identical proteins and their annotated locations for XP_006531749.1

UniProtKB/Swiss-Prot

O09004, Q80WC0, Q8BSC8, Q9QUG9

Conserved Domains (4) summary

smart00147
Location:150 → 387

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:7 → 121

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd00029
Location:499 → 548

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00051
Location:430 → 481

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
XM_030250783.2 → XP_030106643.1 RAS guanyl-releasing protein 2 isoform X2

Conserved Domains (4) summary

smart00147
Location:113 → 350

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:1 → 84

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd00029
Location:462 → 511

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00051
Location:393 → 444

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
XM_006531692.5 → XP_006531755.1 RAS guanyl-releasing protein 2 isoform X3

Conserved Domains (4) summary

smart00147
Location:78 → 315

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd00029
Location:427 → 476

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00051
Location:358 → 409

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cl02520
Location:2 → 49

REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
XM_030250790.2 → XP_030106650.1 RAS guanyl-releasing protein 2 isoform X5

Conserved Domains (3) summary

smart00147
Location:5 → 242

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd00029
Location:354 → 403

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00051
Location:285 → 336

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
XM_030250787.1 → XP_030106647.1 RAS guanyl-releasing protein 2 isoform X4

Conserved Domains (4) summary

smart00147
Location:150 → 387

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:7 → 121

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cl25354
Location:401 → 451

EFh_CREC; EF-hand, calcium binding motif, found in CREC-EF hand family

pfam00036
Location:431 → 452

EF-hand_1; EF hand
XM_036161468.1 → XP_036017361.1 RAS guanyl-releasing protein 2 isoform X6

UniProtKB/TrEMBL

D6RDD3

Conserved Domains (1) summary

smart00229
Location:7 → 121

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
XM_006531688.3 → XP_006531751.1 RAS guanyl-releasing protein 2 isoform X1

See identical proteins and their annotated locations for XP_006531751.1

UniProtKB/Swiss-Prot

O09004, Q80WC0, Q8BSC8, Q9QUG9

Related

ENSMUSP00000041135.9, ENSMUST00000035716.15

Conserved Domains (4) summary

smart00147
Location:150 → 387

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:7 → 121

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd00029
Location:499 → 548

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00051
Location:430 → 481

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
XM_030250786.1 → XP_030106646.1 RAS guanyl-releasing protein 2 isoform X2

Conserved Domains (4) summary

smart00147
Location:113 → 350

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:1 → 84

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd00029
Location:462 → 511

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00051
Location:393 → 444

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
XM_011248615.2 → XP_011246917.1 RAS guanyl-releasing protein 2 isoform X5

See identical proteins and their annotated locations for XP_011246917.1

Conserved Domains (3) summary

smart00147
Location:5 → 242

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd00029
Location:354 → 403

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00051
Location:285 → 336

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
XM_030250789.1 → XP_030106649.1 RAS guanyl-releasing protein 2 isoform X5

Conserved Domains (3) summary

smart00147
Location:5 → 242

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd00029
Location:354 → 403

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00051
Location:285 → 336

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
XM_030250785.1 → XP_030106645.1 RAS guanyl-releasing protein 2 isoform X2

Conserved Domains (4) summary

smart00147
Location:113 → 350

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:1 → 84

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd00029
Location:462 → 511

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00051
Location:393 → 444

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
XM_006531690.3 → XP_006531753.1 RAS guanyl-releasing protein 2 isoform X1

See identical proteins and their annotated locations for XP_006531753.1

UniProtKB/Swiss-Prot

O09004, Q80WC0, Q8BSC8, Q9QUG9

Conserved Domains (4) summary

smart00147
Location:150 → 387

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:7 → 121

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd00029
Location:499 → 548

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00051
Location:430 → 481

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
XM_030250791.1 → XP_030106651.1 RAS guanyl-releasing protein 2 isoform X5

Conserved Domains (3) summary

smart00147
Location:5 → 242

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd00029
Location:354 → 403

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00051
Location:285 → 336

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
XM_036161467.1 → XP_036017360.1 RAS guanyl-releasing protein 2 isoform X6

UniProtKB/TrEMBL

D6RDD3

Conserved Domains (1) summary

smart00229
Location:7 → 121

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
XM_011248613.4 → XP_011246915.1 RAS guanyl-releasing protein 2 isoform X4

Conserved Domains (4) summary

smart00147
Location:150 → 387

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:7 → 121

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cl25354
Location:401 → 451

EFh_CREC; EF-hand, calcium binding motif, found in CREC-EF hand family

pfam00036
Location:431 → 452

EF-hand_1; EF hand
XM_017318082.1 → XP_017173571.1 RAS guanyl-releasing protein 2 isoform X5

Conserved Domains (3) summary

smart00147
Location:5 → 242

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd00029
Location:354 → 403

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00051
Location:285 → 336

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...