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    Abhd16a abhydrolase domain containing 16A [ Mus musculus (house mouse) ]

    Gene ID: 193742, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Abhd16aprovided by MGI
    Official Full Name
    abhydrolase domain containing 16Aprovided by MGI
    Primary source
    MGI:MGI:99476
    See related
    Ensembl:ENSMUSG00000007036 AllianceGenome:MGI:99476
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bat5; NG26; Bat-5; mBAT5; D17H6S82E
    Summary
    Enables acylglycerol lipase activity and phospholipase activity. Involved in monoacylglycerol catabolic process; phosphatidylserine catabolic process; and prostaglandin catabolic process. Predicted to be integral component of membrane. Predicted to be active in membrane. Orthologous to human ABHD16A (abhydrolase domain containing 16A, phospholipase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 54.1), adrenal adult (RPKM 49.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 B1; 17 18.59 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35308210..35321963)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35089234..35102987)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene lymphocyte antigen 6 family member G6D Neighboring gene STARR-seq mESC enhancer starr_42446 Neighboring gene lymphocyte antigen 6 family member G6E Neighboring gene lymphocyte antigen 6 family member G6F Neighboring gene STARR-positive B cell enhancer ABC_E7527 Neighboring gene lymphocyte antigen 6 family member G5C Neighboring gene lymphocyte antigen 6 family member G5B Neighboring gene casein kinase 2, beta polypeptide

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mapping the Neuroanatomy of ABHD16A, ABHD12, and Lysophosphatidylserines Provides New Insights into the Pathophysiology of the Human Neurological Disorder PHARC. Singh S, et al. Biochemistry, 2020 Jun 23. PMID 32462874, Free PMC Article
    2. Identification of a recombinational breakpoint at the BAT5 locus in three intra-H-2 recombinant inbred mouse strains. Mathew PA, et al. Exp Clin Immunogenet, 1995. PMID 8919359
    3. MHC-linked diabetogenic gene of the NOD mouse: molecular mapping of the 3' boundary of the diabetogenic region. Ikegami H, et al. Biochem Biophys Res Commun, 1993 Apr 30. PMID 8097912
    4. Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay. Kamat SS, et al. Nat Chem Biol, 2015 Feb. PMID 25580854, Free PMC Article
    5. Biochemical and pharmacological characterization of the human lymphocyte antigen B-associated transcript 5 (BAT5/ABHD16A). Savinainen JR, et al. PLoS One, 2014. PMID 25290914, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mapping the Neuroanatomy of ABHD16A, ABHD12, and Lysophosphatidylserines Provides New Insights into the Pathophysiology of the Human Neurological Disorder PHARC.
      Title: Mapping the Neuroanatomy of ABHD16A, ABHD12, and Lysophosphatidylserines Provides New Insights into the Pathophysiology of the Human Neurological Disorder PHARC.
    2. BAT5 is a genuine lipase with preference for long-chain unsaturated monoacylglycerols, and could in this capacity regulate glycerolipid metabolism in vivo as well.
      Title: Biochemical and pharmacological characterization of the human lymphocyte antigen B-associated transcript 5 (BAT5/ABHD16A).
    3. In mouse macrophages, disruption of ABHD12 and ABHD16A respectively increases and decreases both lysophosphatidylserines and lipopolysaccharide-induced cytokine production.
      Title: Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC19234

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acylglycerol lipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acylglycerol lipase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acylglycerol lipase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoacylglycerol catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoacylglycerol catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in monoacylglycerol catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylserine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylserine catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in prostaglandin catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in prostaglandin catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylserine lipase ABHD16A
    Names
    HLA-B associated transcript 5
    abhydrolase domain-containing protein 16A
    alpha/beta hydrolase domain-containing protein 16A
    monoacylglycerol lipase ABHD16A
    protein ABHD16A
    protein BAT5
    NP_001397269.1
    NP_001397270.1
    NP_001397271.1
    NP_001397272.1
    NP_001397274.1
    NP_001397275.1
    NP_001397276.1
    NP_001404608.1
    NP_848707.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410340.1 → NP_001397269.1  phosphatidylserine lipase ABHD16A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC087117

    2. NM_001410341.1 → NP_001397270.1  phosphatidylserine lipase ABHD16A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC087117

    3. NM_001410342.1 → NP_001397271.1  phosphatidylserine lipase ABHD16A isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC087117

    4. NM_001410343.1 → NP_001397272.1  phosphatidylserine lipase ABHD16A isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC087117

    5. NM_001410345.1 → NP_001397274.1  phosphatidylserine lipase ABHD16A isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC087117

    6. NM_001410346.1 → NP_001397275.1  phosphatidylserine lipase ABHD16A isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC087117

    7. NM_001410347.1 → NP_001397276.1  phosphatidylserine lipase ABHD16A isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC087117

    8. NM_001417679.1 → NP_001404608.1  phosphatidylserine lipase ABHD16A isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC087117

    9. NM_178592.4 → NP_848707.1  phosphatidylserine lipase ABHD16A isoform 1

      See identical proteins and their annotated locations for NP_848707.1

      Status: VALIDATED

      Source sequence(s)
      AC087117
      Consensus CDS
      CCDS28681.1
      UniProtKB/Swiss-Prot
      Q9Z1Q2
      Related
      ENSMUSP00000007251.8, ENSMUST00000007251.14
      Conserved Domains (1) summary
      pfam00561
      Location:280 → 408
      Abhydrolase_1; alpha/beta hydrolase fold

    RNA

    1. NR_177060.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC087117

    2. NR_177061.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC087117
      Related
      ENSMUST00000173846.8

    3. NR_184561.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC087117

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      35308210..35321963
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004939480.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z1Q2.3 GenPept UniProtKB/Swiss-Prot:Q9Z1Q2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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