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    Rnf185 ring finger protein 185 [ Mus musculus (house mouse) ]

    Gene ID: 193670, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Rnf185provided by MGI
    Official Full Name
    ring finger protein 185provided by MGI
    Primary source
    MGI:MGI:1922078
    See related
    Ensembl:ENSMUSG00000020448 AllianceGenome:MGI:1922078
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable ubiquitin binding activity; ubiquitin protein ligase activity; and ubiquitin-like protein conjugating enzyme binding activity. Predicted to be involved in ERAD pathway; positive regulation of ERAD pathway; and protein autoubiquitination. Predicted to act upstream of or within autophagy. Predicted to be located in endoplasmic reticulum. Is expressed in genitourinary system and olfactory epithelium. Orthologous to human RNF185 (ring finger protein 185). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 16.3), kidney adult (RPKM 15.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rnf185 in Genome Data Viewer
    Location:
    11 A1; 11 2.4 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (3365973..3402956, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (3415973..3452956, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12592 Neighboring gene STARR-positive B cell enhancer ABC_E5203 Neighboring gene STARR-positive B cell enhancer ABC_E2345 Neighboring gene STARR-positive B cell enhancer ABC_E3929 Neighboring gene phosphoinositide-3-kinase interacting protein 1 Neighboring gene STARR-seq mESC enhancer starr_28349 Neighboring gene LIM domain kinase 2 Neighboring gene STARR-seq mESC enhancer starr_28351 Neighboring gene STARR-positive B cell enhancer ABC_E1818 Neighboring gene predicted gene, 51879 Neighboring gene RIKEN cDNA 8430429K09 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:3352424-3352533 Neighboring gene predicted gene, 53661 Neighboring gene 39S ribosomal protein L30, mitochondrial pseudogene Neighboring gene phospholipase A2, group III Neighboring gene inositol polyphosphate 5-phosphatase J

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
    2. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812
    3. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767
    4. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC19394, 1700022N24Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-like protein conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-like protein conjugating enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of type I interferon-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K27-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RNF185
    Names
    RING-type E3 ubiquitin transferase RNF185
    NP_001277401.1
    NP_001277402.1
    NP_663330.2
    XP_006514657.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290472.1 → NP_001277401.1  E3 ubiquitin-protein ligase RNF185 isoform 2

      See identical proteins and their annotated locations for NP_001277401.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks part of the 5' coding region and uses a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK034108, AK075756, AL713875, AV347010
      Consensus CDS
      CCDS70127.1
      UniProtKB/Swiss-Prot
      Q6ZWS3, Q91YT2
      Related
      ENSMUSP00000076333.6, ENSMUST00000077078.12
      Conserved Domains (1) summary
      cd00162
      Location:38 → 83
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    2. NM_001290473.1 → NP_001277402.1  E3 ubiquitin-protein ligase RNF185 isoform 3

      See identical proteins and their annotated locations for NP_001277402.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in its 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (3) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK034108, AK075756, AL713875, AV347010
      UniProtKB/Swiss-Prot
      Q91YT2
      Conserved Domains (2) summary
      PLN03208
      Location:29 → 65
      PLN03208; E3 ubiquitin-protein ligase RMA2; Provisional
      cl17238
      Location:8 → 33
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    3. NM_145355.5 → NP_663330.2  E3 ubiquitin-protein ligase RNF185 isoform 1

      See identical proteins and their annotated locations for NP_663330.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK034108, AK075756, AL713875, AV347010
      Consensus CDS
      CCDS24361.1
      UniProtKB/Swiss-Prot
      Q91YT2
      Related
      ENSMUSP00000067053.3, ENSMUST00000064364.3
      Conserved Domains (1) summary
      cd00162
      Location:74 → 119
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RNA

    1. NR_110959.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two consecutive internal exons, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AK034108, AK075756, AL713875, AV347010

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      3365973..3402956 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514594.5 → XP_006514657.1  E3 ubiquitin-protein ligase RNF185 isoform X1

      See identical proteins and their annotated locations for XP_006514657.1

      Conserved Domains (2) summary
      PLN03208
      Location:29 → 65
      PLN03208; E3 ubiquitin-protein ligase RMA2; Provisional
      cl17238
      Location:8 → 33
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91YT2.1 GenPept UniProtKB/Swiss-Prot:Q91YT2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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