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    Rad54l RAD54 like (S. cerevisiae) [ Mus musculus (house mouse) ]

    Gene ID: 19366, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Rad54lprovided by MGI
    Official Full Name
    RAD54 like (S. cerevisiae)provided by MGI
    Primary source
    MGI:MGI:894697
    See related
    Ensembl:ENSMUSG00000028702 AllianceGenome:MGI:894697
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RAD54
    Summary
    Predicted to enable ATP-dependent DNA/DNA annealing activity and DNA translocase activity. Acts upstream of or within several processes, including determination of adult lifespan; double-strand break repair via homologous recombination; and response to ionizing radiation. Predicted to be located in nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Is expressed in alimentary system; brain ventricular layer; metencephalon rest of alar plate marginal layer; renal cortex; and vibrissa. Used to study sclerocornea. Human ortholog(s) of this gene implicated in breast cancer; disease of cellular proliferation; non-Hodgkin lymphoma; and pancreatic cancer. Orthologous to human RAD54L (RAD54 like). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 12.3), testis adult (RPKM 10.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 D1; 4 53.1 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (115951458..115980875, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (116094261..116123700, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12854 Neighboring gene STARR-positive B cell enhancer ABC_E4647 Neighboring gene ubiquinol-cytochrome c reductase hinge protein Neighboring gene leucine rich repeat containing 41 Neighboring gene predicted gene, 52704 Neighboring gene RIKEN cDNA 2510003B16 gene Neighboring gene STARR-positive B cell enhancer ABC_E10248 Neighboring gene STARR-seq mESC enhancer starr_11132 Neighboring gene leucine rich adaptor protein 1 Neighboring gene protein O-linked mannose beta 1,2-N-acetylglucosaminyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Gene conversion-like sequence transfers between transgenic antibody V genes are independent of RAD54. D'Avirro N, et al. J Immunol, 2002 Sep 15. PMID 12218123
    2. Homologous and non-homologous recombination differentially affect DNA damage repair in mice. Essers J, et al. EMBO J, 2000 Apr 3. PMID 10747037, Free PMC Article
    3. Disruption of mouse RAD54 reduces ionizing radiation resistance and homologous recombination. Essers J, et al. Cell, 1997 Apr 18. PMID 9108475
    4. Rad54 and Mus81 cooperation promotes DNA damage repair and restrains chromosome missegregation. Ghamrasni SE, et al. Oncogene, 2016 Sep 15. PMID 26876210
    5. BLM has early and late functions in homologous recombination repair in mouse embryonic stem cells. Chu WK, et al. Oncogene, 2010 Aug 19. PMID 20531307

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Our study highlights the importance of the cooperation between Rad54 and Mus81 for mediating DNA DSB repair and restraining chromosome missegregation.
      Title: Rad54 and Mus81 cooperation promotes DNA damage repair and restrains chromosome missegregation.
    2. These results reveal a differential interaction of the ATM-mediated DNA damage response and Rad54 paralog-mediated homologous recombination depending on the DNA damaging agent that initiates the response.
      Title: Analysis of the relationships between ATM and the Rad54 paralogs involved in homologous recombination repair.
    3. Mus81-Eme1- and Rad54-mediated homologous recombination are involved in the same DNA replication-dependent interstrand crosslinks repair pathway
      Title: The structure-specific endonuclease Mus81-Eme1 promotes conversion of interstrand DNA crosslinks into double-strands breaks.
    4. Rad54 is not required for either transgene isotype switching or transgene hypermutation.
      Title: Gene conversion-like sequence transfers between transgenic antibody V genes are independent of RAD54.
    5. Rad54-mediated homologous recombination is not essential for somatic hypermutation. In addition, the finding that the ablation of RAD51 paralogues causes an increase in SHM argues against a direct involvement of HR in promoting SHM.
      Title: Somatic hypermutation does not require Rad54 and Rad54B-mediated homologous recombination.
    6. Rad54 cooperates with DNA Ligase IV to support cellular proliferation, dna repair, and prevent chromosome and single chromatid aberrations
      Title: Rad54 and DNA Ligase IV cooperate to maintain mammalian chromatid stability.
    7. Rad54 has a role in telomere length maintenance
      Title: Role of mammalian Rad54 in telomere length maintenance.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 
    • Targeted (3)  1 citation
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent DNA/DNA annealing activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP-dependent chromatin remodeler activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA translocase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chromosome organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within determination of adult lifespan IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within double-strand break repair IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within double-strand break repair via homologous recombination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair via synthesis-dependent strand annealing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in reciprocal meiotic recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to ionizing radiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to ionizing radiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNA repair and recombination protein RAD54-like
    Names
    RAD54 homolog
    mHR54
    mRAD54
    NP_001116430.1
    NP_001116431.1
    NP_001411773.1
    NP_001411774.1
    NP_001411775.1
    NP_001411776.1
    NP_001411777.1
    NP_033041.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122958.2 → NP_001116430.1  DNA repair and recombination protein RAD54-like isoform 1

      See identical proteins and their annotated locations for NP_001116430.1

      Status: VALIDATED

      Source sequence(s)
      AL611947, AL627105
      Consensus CDS
      CCDS18504.1
      UniProtKB/Swiss-Prot
      P70270, Q8BSR5, Q8C2C4, Q8K3D4
      Related
      ENSMUSP00000099766.4, ENSMUST00000102705.10
      Conserved Domains (3) summary
      COG0553
      Location:107 → 668
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd18067
      Location:153 → 395
      DEXHc_RAD54A; DEXH-box helicase domain of RAD54A
      pfam08658
      Location:76 → 123
      Rad54_N; Rad54 N terminal

    2. NM_001122959.2 → NP_001116431.1  DNA repair and recombination protein RAD54-like isoform 1

      See identical proteins and their annotated locations for NP_001116431.1

      Status: VALIDATED

      Source sequence(s)
      AL611947, AL627105
      Consensus CDS
      CCDS18504.1
      UniProtKB/Swiss-Prot
      P70270, Q8BSR5, Q8C2C4, Q8K3D4
      Conserved Domains (3) summary
      COG0553
      Location:107 → 668
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd18067
      Location:153 → 395
      DEXHc_RAD54A; DEXH-box helicase domain of RAD54A
      pfam08658
      Location:76 → 123
      Rad54_N; Rad54 N terminal

    3. NM_001424844.1 → NP_001411773.1  DNA repair and recombination protein RAD54-like isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL611947, AL627105
      UniProtKB/Swiss-Prot
      P70270, Q8BSR5, Q8C2C4, Q8K3D4

    4. NM_001424845.1 → NP_001411774.1  DNA repair and recombination protein RAD54-like isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL611947, AL627105
      UniProtKB/Swiss-Prot
      P70270, Q8BSR5, Q8C2C4, Q8K3D4

    5. NM_001424846.1 → NP_001411775.1  DNA repair and recombination protein RAD54-like isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL611947, AL627105

    6. NM_001424847.1 → NP_001411776.1  DNA repair and recombination protein RAD54-like isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL611947, AL627105

    7. NM_001424848.1 → NP_001411777.1  DNA repair and recombination protein RAD54-like isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL611947, AL627105

    8. NM_009015.4 → NP_033041.3  DNA repair and recombination protein RAD54-like isoform 1

      See identical proteins and their annotated locations for NP_033041.3

      Status: VALIDATED

      Source sequence(s)
      AL611947, AL627105
      Consensus CDS
      CCDS18504.1
      UniProtKB/Swiss-Prot
      P70270, Q8BSR5, Q8C2C4, Q8K3D4
      Related
      ENSMUSP00000099765.4, ENSMUST00000102704.4
      Conserved Domains (3) summary
      COG0553
      Location:107 → 668
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd18067
      Location:153 → 395
      DEXHc_RAD54A; DEXH-box helicase domain of RAD54A
      pfam08658
      Location:76 → 123
      Rad54_N; Rad54 N terminal

    RNA

    1. NR_188962.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL611947, AL627105

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      115951458..115980875 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P70270.2 GenPept UniProtKB/Swiss-Prot:P70270

    Gene LinkOut

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