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    Rad1 RAD1 checkpoint DNA exonuclease [ Mus musculus (house mouse) ]

    Gene ID: 19355, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Rad1provided by MGI
    Official Full Name
    RAD1 checkpoint DNA exonucleaseprovided by MGI
    Primary source
    MGI:MGI:1316678
    See related
    Ensembl:ENSMUSG00000022248 AllianceGenome:MGI:1316678
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mRAD1
    Summary
    Predicted to enable 3'-5' exonuclease activity. Predicted to be involved in DNA repair; cellular response to ionizing radiation; and negative regulation of cell cycle phase transition. Predicted to act upstream of or within cellular response to DNA damage stimulus. Predicted to be located in chromosome and nucleoplasm. Predicted to be part of checkpoint clamp complex. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and hemolymphoid system gland. Orthologous to human RAD1 (RAD1 checkpoint DNA exonuclease). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 3.3), liver E14 (RPKM 2.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15 A1; 15 5.35 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (10486104..10499149)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (10486018..10499063)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C21 Neighboring gene STARR-positive B cell enhancer ABC_E9414 Neighboring gene STARR-seq mESC enhancer starr_37954 Neighboring gene BRX1, biogenesis of ribosomes Neighboring gene tetratricopeptide repeat domain 23-like Neighboring gene STARR-seq mESC enhancer starr_37955 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene retinoic acid induced 14 Neighboring gene predicted gene 10389

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Targeted deletion of mouse Rad1 leads to deficient cellular DNA damage responses. Zhang C, et al. Protein Cell, 2011 May. PMID 21637962, Free PMC Article
    2. Mouse Rad1 deletion enhances susceptibility for skin tumor development. Han L, et al. Mol Cancer, 2010 Mar 24. PMID 20334655, Free PMC Article
    3. A human and mouse homolog of the Schizosaccharomyces pombe rad1+ cell cycle checkpoint control gene. Bluyssen HA, et al. Genomics, 1998 Dec 1. PMID 9828137
    4. Lysine residue 185 of Rad1 is a topological but not a functional counterpart of lysine residue 164 of PCNA. Wit N, et al. PLoS One, 2011 Jan 31. PMID 21304913, Free PMC Article
    5. HRAD1 and MRAD1 encode mammalian homologues of the fission yeast rad1(+) cell cycle checkpoint control gene. Udell CM, et al. Nucleic Acids Res, 1998 Sep 1. PMID 9705507, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HUS1 acts as a component of the canonical 9-1-1 complex during meiotic prophase I to promote DSB repair and further propose that RAD1 and TOPBP1 respond to unsynapsed chromatin through an alternative mechanism that does not require RAD9 or HUS1.
      Title: Conditional inactivation of the DNA damage response gene Hus1 in mouse testis reveals separable roles for components of the RAD9-RAD1-HUS1 complex in meiotic chromosome maintenance.
    2. The rad1 protein is required for repairing DNA lesions induced by UV-light, HU and gamma rays, and for mediating G(2)/M and S/M checkpoint controls.
      Title: Targeted deletion of mouse Rad1 leads to deficient cellular DNA damage responses.
    3. data indicate that Rad1(K185) is not a functional counterpart of PCNA(K164).
      Title: Lysine residue 185 of Rad1 is a topological but not a functional counterpart of lysine residue 164 of PCNA.
    4. data suggest that Mrad1 is important for preventing tumor development.
      Title: Mouse Rad1 deletion enhances susceptibility for skin tumor development.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in meiotic recombination checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of checkpoint clamp complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of checkpoint clamp complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cell cycle checkpoint protein RAD1
    Names
    DNA repair exonuclease rad1 homolog
    RAD1 homolog
    rad1-like DNA damage checkpoint protein
    NP_001276376.1
    NP_001276377.1
    NP_001398639.1
    NP_035362.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289447.2 → NP_001276376.1  cell cycle checkpoint protein RAD1

      See identical proteins and their annotated locations for NP_001276376.1

      Status: VALIDATED

      Source sequence(s)
      AC102101
      Consensus CDS
      CCDS27379.1
      UniProtKB/Swiss-Prot
      O70452, O88391, Q3TGU1, Q3UG66, Q9QWZ1, Q9QWZ3
      Conserved Domains (1) summary
      pfam02144
      Location:17 → 257
      Rad1; Repair protein Rad1/Rec1/Rad17

    2. NM_001289448.1 → NP_001276377.1  cell cycle checkpoint protein RAD1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and 3' coding region compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC102101, AK168588
      Consensus CDS
      CCDS70618.1
      UniProtKB/Swiss-Prot
      Q9QWZ1
      Related
      ENSMUSP00000098338.4, ENSMUST00000100775.10
      Conserved Domains (2) summary
      cd00577
      Location:19 → 228
      PCNA; Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These polymerase processivity factors play a role in DNA replication and repair. PCNA encircles duplex DNA in its central cavity, providing a DNA-bound platform for the ...
      pfam02144
      Location:17 → 222
      Rad1; Repair protein Rad1/Rec1/Rad17

    3. NM_001411710.1 → NP_001398639.1  cell cycle checkpoint protein RAD1

      Status: VALIDATED

      Source sequence(s)
      AC102101
      UniProtKB/Swiss-Prot
      O70452, O88391, Q3TGU1, Q3UG66, Q9QWZ1, Q9QWZ3

    4. NM_011232.4 → NP_035362.2  cell cycle checkpoint protein RAD1

      See identical proteins and their annotated locations for NP_035362.2

      Status: VALIDATED

      Source sequence(s)
      AC102101
      Consensus CDS
      CCDS27379.1
      UniProtKB/Swiss-Prot
      O70452, O88391, Q3TGU1, Q3UG66, Q9QWZ1, Q9QWZ3
      Related
      ENSMUSP00000022856.9, ENSMUST00000022856.15
      Conserved Domains (1) summary
      pfam02144
      Location:17 → 257
      Rad1; Repair protein Rad1/Rec1/Rad17

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      10486104..10499149
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QWZ1.1 GenPept UniProtKB/Swiss-Prot:Q9QWZ1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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