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    Rab5c RAB5C, member RAS oncogene family [ Mus musculus (house mouse) ]

    Gene ID: 19345, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Rab5cprovided by MGI
    Official Full Name
    RAB5C, member RAS oncogene familyprovided by MGI
    Primary source
    MGI:MGI:105306
    See related
    Ensembl:ENSMUSG00000019173 AllianceGenome:MGI:105306
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rabl
    Summary
    Predicted to enable GDP binding activity and GTPase activity. Acts upstream of or within endosome organization and regulation of endocytosis. Located in endocytic vesicle. Is expressed in several structures, including heart; intestine; liver; lung; and spleen. Orthologous to human RAB5C (RAB5C, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in kidney adult (RPKM 167.3), duodenum adult (RPKM 128.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 D; 11 63.54 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100605829..100629041, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100715003..100738215, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene K(lysine) acetyltransferase 2A Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:100575167-100575276 Neighboring gene heat shock protein, alpha-crystallin-related, B9 Neighboring gene STARR-positive B cell enhancer ABC_E3022 Neighboring gene potassium voltage-gated channel, subfamily H (eag-related), member 4 Neighboring gene STARR-positive B cell enhancer ABC_E8452 Neighboring gene hypocretin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Structural plasticity of an invariant hydrophobic triad in the switch regions of Rab GTPases is a determinant of effector recognition. Merithew E, et al. J Biol Chem, 2001 Apr 27. PMID 11278565
    2. Rab5 is necessary for the biogenesis of the endolysosomal system in vivo. Zeigerer A, et al. Nature, 2012 May 23. PMID 22622570
    3. IL-6 and IL-12 specifically regulate the expression of Rab5 and Rab7 via distinct signaling pathways. Bhattacharya M, et al. EMBO J, 2006 Jun 21. PMID 16763563, Free PMC Article
    4. Rab17, a novel small GTPase, is specific for epithelial cells and is induced during cell polarization. Lütcke A, et al. J Cell Biol, 1993 May. PMID 8486736, Free PMC Article
    5. A growth factor signaling cascade confined to circular ruffles in macrophages. Welliver TP, et al. Biol Open, 2012 Aug 15. PMID 23213469, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GDP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within endosome organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in plasma membrane to endosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of endocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endocytic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ras-related protein Rab-5C
    NP_001291932.1
    NP_077776.2
    XP_036012345.1
    XP_036012346.1
    XP_036012347.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305003.1 → NP_001291932.1  ras-related protein Rab-5C isoform 2

      See identical proteins and their annotated locations for NP_001291932.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the penultimate exon, compared to variant 1. It encodes isoform 2 which is longer than isoform 1.
      Source sequence(s)
      AK159832, AL591469, BE447216, BY081527
      Consensus CDS
      CCDS79048.1
      UniProtKB/TrEMBL
      Q3TCT9, Q8C266
      Related
      ENSMUSP00000019317.6, ENSMUST00000019317.12
      Conserved Domains (2) summary
      cd01860
      Location:21 → 201
      Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion
      pfam00071
      Location:23 → 202
      Ras; Ras family

    2. NM_024456.5 → NP_077776.2  ras-related protein Rab-5C isoform 1

      See identical proteins and their annotated locations for NP_077776.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
      Source sequence(s)
      AK159832, AL591469, BE447216, BY081527
      Consensus CDS
      CCDS36333.1
      UniProtKB/Swiss-Prot
      P35278, Q8R1V8, Q8R2N8
      UniProtKB/TrEMBL
      Q3TCT9, Q3TJ39
      Related
      ENSMUSP00000102987.2, ENSMUST00000107364.8
      Conserved Domains (1) summary
      cd01860
      Location:21 → 183
      Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      100605829..100629041 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156453.1 → XP_036012346.1  ras-related protein Rab-5C isoform X2

      UniProtKB/TrEMBL
      Q3TCT9
      Conserved Domains (1) summary
      cd01860
      Location:67 → 229
      Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion

    2. XM_036156452.1 → XP_036012345.1  ras-related protein Rab-5C isoform X1

      Conserved Domains (1) summary
      cd01860
      Location:67 → 247
      Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion

    3. XM_036156454.1 → XP_036012347.1  ras-related protein Rab-5C isoform X3

      UniProtKB/Swiss-Prot
      P35278, Q8R1V8, Q8R2N8
      UniProtKB/TrEMBL
      Q3TCT9, Q3TJ39
      Conserved Domains (1) summary
      cd01860
      Location:21 → 183
      Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35278.2 GenPept UniProtKB/Swiss-Prot:P35278

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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