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    Rab33a RAB33A, member RAS oncogene family [ Mus musculus (house mouse) ]

    Gene ID: 19337, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Rab33aprovided by MGI
    Official Full Name
    RAB33A, member RAS oncogene familyprovided by MGI
    Primary source
    MGI:MGI:109493
    See related
    Ensembl:ENSMUSG00000031104 AllianceGenome:MGI:109493
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rabs10
    Summary
    This gene encodes a member of the Ras-related small GTPases, which regulate membrane trafficking in organelles and transport vesicles. This protein has been reported to be expressed in lymphocytes and in regions of the mouse brain, specifically the cortex, hippocampus and also the olfactory bulb. The ortholog of this protein in rat has been characterized and may participate in anterograde trafficking of synaptophysin-positive vesicles to the plasma membrane. [provided by RefSeq, Jun 2013]
    Expression
    Biased expression in CNS E18 (RPKM 32.4), CNS E14 (RPKM 23.2) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    X 25.68 cM; X A5
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (47602540..47619112)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (48513663..48530240)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:45782874-45783027 Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:45786781-45786934 Neighboring gene E74 like ETS transcription factor 4 Neighboring gene apoptosis-inducing factor, mitochondrion-associated 1 Neighboring gene STARR-seq mESC enhancer starr_47122 Neighboring gene zinc finger protein 280C Neighboring gene solute carrier family 25 (mitochondrial carrier, brain), member 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Rab33A: characterization, expression, and suppression by epigenetic modification. Cheng E, et al. J Invest Dermatol, 2006 Oct. PMID 16810302
    2. Structure and expression of the mouse S10 gene. Zheng JY, et al. Biochim Biophys Acta, 1997 Mar 20. PMID 9116044
    3. Rab33a mediates anterograde vesicular transport for membrane exocytosis and axon outgrowth. Nakazawa H, et al. J Neurosci, 2012 Sep 12. PMID 22972995, Free PMC Article
    4. Molecular cloning of a cDNA encoding a novel small GTP-binding protein. Koda T, et al. FEBS Lett, 1993 Aug 9. PMID 7688322
    5. A novel Rab GTPase, Rab33B, is ubiquitously expressed and localized to the medial Golgi cisternae. Zheng JY, et al. J Cell Sci, 1998 Apr. PMID 9512502

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC129488, MGC129489

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Rab protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in antigen processing and presentation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ras-related protein Rab-33A
    Names
    RAB33A, member of RAS oncogene family
    small GTP-binding protein S10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001425935.1 → NP_001412864.1  ras-related protein Rab-33A isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL669901

    2. NM_001425936.1 → NP_001412865.1  ras-related protein Rab-33A isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL669901

    3. NM_011228.3 → NP_035358.1  ras-related protein Rab-33A isoform 1

      See identical proteins and their annotated locations for NP_035358.1

      Status: REVIEWED

      Source sequence(s)
      AL669901
      Consensus CDS
      CCDS30110.1
      UniProtKB/Swiss-Prot
      P97950
      UniProtKB/TrEMBL
      Q3SXA7
      Related
      ENSMUSP00000033430.3, ENSMUST00000033430.3
      Conserved Domains (1) summary
      cd04115
      Location:35 → 204
      Rab33B_Rab33A; Rab GTPase family 33 includes Rab33A and Rab33B

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      47602540..47619112
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251262.2 → XP_030107122.1  ras-related protein Rab-33A isoform X2

      UniProtKB/Swiss-Prot
      P97950
      UniProtKB/TrEMBL
      Q3SXA7
      Conserved Domains (1) summary
      cd04115
      Location:35 → 204
      Rab33B_Rab33A; Rab GTPase family 33 includes Rab33A and Rab33B

    2. XM_036161859.1 → XP_036017752.1  ras-related protein Rab-33A isoform X1

      Conserved Domains (1) summary
      cl38936
      Location:108 → 225
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. XM_036161860.1 → XP_036017753.1  ras-related protein Rab-33A isoform X2

      UniProtKB/Swiss-Prot
      P97950
      UniProtKB/TrEMBL
      Q3SXA7
      Conserved Domains (1) summary
      cd04115
      Location:35 → 204
      Rab33B_Rab33A; Rab GTPase family 33 includes Rab33A and Rab33B

    4. XM_036161858.1 → XP_036017751.1  ras-related protein Rab-33A isoform X1

      Conserved Domains (1) summary
      cl38936
      Location:108 → 225
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    5. XM_030251263.1 → XP_030107123.1  ras-related protein Rab-33A isoform X4

      Conserved Domains (1) summary
      cl38936
      Location:1 → 103
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    6. XM_036161861.1 → XP_036017754.1  ras-related protein Rab-33A isoform X3

      Conserved Domains (1) summary
      cl38936
      Location:2 → 119
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97950.1 GenPept UniProtKB/Swiss-Prot:P97950

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