Rab10 RAB10, member RAS oncogene family [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rab10provided by MGI
Official Full Name: RAB10, member RAS oncogene familyprovided by MGI
Primary source: MGI:MGI:105066
See related: Ensembl:ENSMUSG00000020671 AllianceGenome:MGI:105066
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable GDP-dissociation inhibitor binding activity; guanyl ribonucleotide binding activity; and myosin V binding activity. Involved in cellular response to insulin stimulus; protein localization to plasma membrane; and vesicle-mediated transport. Located in Golgi apparatus; cilium; and perinuclear region of cytoplasm. Is expressed in embryo. Orthologous to human RAB10 (RAB10, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E18 (RPKM 55.0), bladder adult (RPKM 47.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 A1.1; 12 1.71 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (3297428..3359969, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (3247428..3309969, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cellular and subcellular localization of Rab10 and phospho-T73 Rab10 in the mouse and human brain.
Title: Cellular and subcellular localization of Rab10 and phospho-T73 Rab10 in the mouse and human brain.
Behavioral and Transcriptome Profiling of Heterozygous Rab10 Knock-Out Mice.
Title: Behavioral and Transcriptome Profiling of Heterozygous Rab10 Knock-Out Mice.
Mice with the Rab10 T73V mutation exhibit anxiety-like behavior and alteration of neuronal functions in the striatum.
Title: Mice with the Rab10 T73V mutation exhibit anxiety-like behavior and alteration of neuronal functions in the striatum.
Rab10 regulates the sorting of internalised TrkB for retrograde axonal transport.
Title: Rab10 regulates the sorting of internalised TrkB for retrograde axonal transport.
Rab10 protects against DOX-induced cardiotoxicity by alleviating the oxidative stress and apoptosis of cardiomyocytes.
Title: Rab10 protects against DOX-induced cardiotoxicity by alleviating the oxidative stress and apoptosis of cardiomyocytes.
Defective insulin-stimulated GLUT4 translocation in brown adipocytes induces systemic glucose homeostasis dysregulation independent of thermogenesis in female mice.
Title: Defective insulin-stimulated GLUT4 translocation in brown adipocytes induces systemic glucose homeostasis dysregulation independent of thermogenesis in female mice.
Rab10-Positive Tubular Structures Represent a Novel Endocytic Pathway That Diverges From Canonical Macropinocytosis in RAW264 Macrophages.
Title: Rab10-Positive Tubular Structures Represent a Novel Endocytic Pathway That Diverges From Canonical Macropinocytosis in RAW264 Macrophages.
Divergent Effects of G2019S and R1441C LRRK2 Mutations on LRRK2 and Rab10 Phosphorylations in Mouse Tissues.
Title: Divergent Effects of G2019S and R1441C LRRK2 Mutations on LRRK2 and Rab10 Phosphorylations in Mouse Tissues.
Insulin-promoted mobilization of GLUT4 from a perinuclear storage site requires RAB10.
Title: Insulin-promoted mobilization of GLUT4 from a perinuclear storage site requires RAB10.
LRRK2 and Rab10 coordinate macropinocytosis to mediate immunological responses in phagocytes.
Title: LRRK2 and Rab10 coordinate macropinocytosis to mediate immunological responses in phagocytes.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (4) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BI283356 (e-PCR)
- UniSTS:243526

RH126769 (e-PCR)
- UniSTS:167265

RAB10_1045 (e-PCR)
- UniSTS:277631

RAB10_V290 (e-PCR)
- UniSTS:277631

AW107754 (e-PCR)
- UniSTS:180362

AU048675 (e-PCR)
- UniSTS:145125

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein activity	IEA Inferred from Electronic Annotation more info
enables GDP binding	ISO Inferred from Sequence Orthology more info
enables GDP-dissociation inhibitor binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	TAS Traceable Author Statement more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables myosin V binding	IBA Inferred from Biological aspect of Ancestor more info
enables myosin V binding	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane transport	ISO Inferred from Sequence Orthology more info
involved_in antigen processing and presentation	ISO Inferred from Sequence Orthology more info
involved_in axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in cellular response to insulin stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endoplasmic reticulum tubular network organization	ISO Inferred from Sequence Orthology more info
involved_in endosomal transport	ISO Inferred from Sequence Orthology more info
involved_in establishment of neuroblast polarity	ISO Inferred from Sequence Orthology more info
involved_in establishment of protein localization to endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
involved_in establishment of protein localization to membrane	ISO Inferred from Sequence Orthology more info
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intracellular protein transport	TAS Traceable Author Statement more info	PubMed
involved_in protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein secretion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulated exocytosis	ISO Inferred from Sequence Orthology more info
involved_in vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cilium	IDA Inferred from Direct Assay more info	PubMed
located_in cilium	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle membrane	TAS Traceable Author Statement more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum tubular network	ISO Inferred from Sequence Orthology more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
located_in exocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in insulin-responsive compartment	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
colocalizes_with plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in recycling endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in recycling endosome	ISO Inferred from Sequence Orthology more info
is_active_in secretory vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ras-related protein Rab-10

NP_057885.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.