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    Lrrc75a leucine rich repeat containing 75A [ Mus musculus (house mouse) ]

    Gene ID: 192976, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Lrrc75aprovided by MGI
    Official Full Name
    leucine rich repeat containing 75Aprovided by MGI
    Primary source
    MGI:MGI:2682293
    See related
    Ensembl:ENSMUSG00000046417 AllianceGenome:MGI:2682293
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam211a
    Summary
    Predicted to be active in cytoplasm. Orthologous to human LRRC75A (leucine rich repeat containing 75A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in colon adult (RPKM 21.1), duodenum adult (RPKM 20.6) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 B2; 11 38.51 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (62495708..62539411, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (62604884..62648523, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2410006H16 gene Neighboring gene small nucleolar RNA, C/D box 49A Neighboring gene small nucleolar RNA, C/D box 65 Neighboring gene leucine rich repeat containing 75A, opposite strand 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:62462281-62462390 Neighboring gene membrane magnesium transporter 2 Neighboring gene zinc finger protein 287 Neighboring gene nuclear encoded tRNA trytophan 8 (anticodon CCA)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC59632

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 75A
    Names
    family with sequence similarity 211, member A
    leucine-rich repeat-containing protein C17orf76 homolog
    leucine-rich repeat-containing protein FAM211A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357955.1 → NP_001344884.1  leucine-rich repeat-containing protein 75A isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region and initiates translation from a downstream start codon, compared to variant 1. It encodes isoform 2, which is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AK146714, BC053455, BY238469
      Conserved Domains (1) summary
      cl26161
      Location:92 → 179
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    2. NM_198861.1 → NP_942561.1  leucine-rich repeat-containing protein 75A isoform 1

      See identical proteins and their annotated locations for NP_942561.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant 1 represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC053455
      Consensus CDS
      CCDS24828.1
      UniProtKB/Swiss-Prot
      Q3UIX7, Q7TSF4, Q811G5
      Related
      ENSMUSP00000062489.9, ENSMUST00000057194.9

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      62495708..62539411 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156450.1 → XP_036012343.1  leucine-rich repeat-containing protein 75A isoform X2

    2. XM_036156449.1 → XP_036012342.1  leucine-rich repeat-containing protein 75A isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TSF4.1 GenPept UniProtKB/Swiss-Prot:Q7TSF4

    Gene LinkOut

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