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    Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 [ Mus musculus (house mouse) ]

    Gene ID: 19289, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Igdcc3provided by MGI
    Official Full Name
    immunoglobulin superfamily, DCC subclass, member 3provided by MGI
    Primary source
    MGI:MGI:1202390
    See related
    Ensembl:ENSMUSG00000032394 AllianceGenome:MGI:1202390
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Punc; WI-14920; 2810401C09Rik
    Summary
    Acts upstream of or within neuromuscular process controlling balance. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; limb primordium; and sensory organ. Orthologous to human IGDCC3 (immunoglobulin superfamily DCC subclass member 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in CNS E11.5 (RPKM 19.1), CNS E14 (RPKM 4.0) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 C; 9 35.13 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (65048404..65094313)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (65141154..65187031)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 pseudogene Neighboring gene dipeptidylpeptidase 8 Neighboring gene STARR-seq mESC enhancer starr_24441 Neighboring gene immunoglobulin superfamily, DCC subclass, member 4 Neighboring gene STARR-seq mESC enhancer starr_24448 Neighboring gene STARR-positive B cell enhancer ABC_E3840 Neighboring gene predicted gene, 40527 Neighboring gene predicted gene, 25313 Neighboring gene RNA, U5G small nuclear

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Punc, a novel mouse gene of the immunoglobulin superfamily, is expressed predominantly in the developing nervous system. Salbaum JM. Mech Dev, 1998 Feb. PMID 9507132
    2. Genomic structure and chromosomal localization of the mouse gene Punc. Salbaum JM. Mamm Genome, 1999 Feb. PMID 9922388
    3. Cloning of vertebrate Protogenin (Prtg) and comparative expression analysis during axis elongation. Vesque C, et al. Dev Dyn, 2006 Oct. PMID 16881056
    4. Cloning and expression of nope, a new mouse gene of the immunoglobulin superfamily related to guidance receptors. Salbaum JM, et al. Genomics, 2000 Feb 15. PMID 10708514
    5. Impaired motor coordination in mice that lack punc. Yang W, et al. Mol Cell Biol, 2001 Sep. PMID 11486040, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2)  1 citation
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within neuromuscular process controlling balance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    immunoglobulin superfamily DCC subclass member 3
    Names
    amplimer WI-14920, mouse homolog
    putative neuronal cell adhesion molecule

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357257.1 → NP_001344186.1  immunoglobulin superfamily DCC subclass member 3 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC110235, AK011916, AK051027
      Consensus CDS
      CCDS90599.1
      UniProtKB/Swiss-Prot
      O70246, Q792T2, Q8BQC3, Q9Z2S6
      Related
      ENSMUSP00000149084.2, ENSMUST00000217371.2
      Conserved Domains (7) summary
      PRK07003
      Location:690 → 812
      PRK07003; DNA polymerase III subunit gamma/tau
      cd00063
      Location:436 → 529
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:556 → 615
      fn3; Fibronectin type III domain
      pfam07679
      Location:343 → 429
      I-set; Immunoglobulin I-set domain
      pfam13927
      Location:250 → 321
      Ig_3; Immunoglobulin domain
      cd00096
      Location:346 → 352
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:53 → 147
      Ig; Immunoglobulin domain

    2. NM_008988.3 → NP_033014.1  immunoglobulin superfamily DCC subclass member 3 isoform 2 precursor

      See identical proteins and their annotated locations for NP_033014.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC110235, AC161366
      Consensus CDS
      CCDS52835.1
      UniProtKB/Swiss-Prot
      Q8BQC3
      Related
      ENSMUSP00000034961.5, ENSMUST00000034961.6
      Conserved Domains (5) summary
      smart00410
      Location:157 → 239
      IG_like; Immunoglobulin like
      cd00063
      Location:436 → 529
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:343 → 429
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:565 → 615
      fn3; Fibronectin type III domain
      cl11960
      Location:56 → 147
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      65048404..65094313
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242679.3 → XP_011240981.2  immunoglobulin superfamily DCC subclass member 3 isoform X1

      Conserved Domains (7) summary
      PRK07003
      Location:569 → 691
      PRK07003; DNA polymerase III subunit gamma/tau
      cd00063
      Location:315 → 408
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:435 → 494
      fn3; Fibronectin type III domain
      pfam07679
      Location:222 → 308
      I-set; Immunoglobulin I-set domain
      pfam13927
      Location:129 → 200
      Ig_3; Immunoglobulin domain
      cd00096
      Location:225 → 231
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:37 → 118
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BQC3.1 GenPept UniProtKB/Swiss-Prot:Q8BQC3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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