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    Ptprm protein tyrosine phosphatase receptor type M [ Mus musculus (house mouse) ]

    Gene ID: 19274, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Ptprmprovided by MGI
    Official Full Name
    protein tyrosine phosphatase receptor type Mprovided by MGI
    Primary source
    MGI:MGI:102694
    See related
    Ensembl:ENSMUSG00000033278 AllianceGenome:MGI:102694
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RPTPmu; mKIAA4044
    Summary
    Predicted to enable cadherin binding activity; identical protein binding activity; and transmembrane receptor protein tyrosine phosphatase activity. Acts upstream of or within vasodilation. Predicted to be located in several cellular components, including adherens junction; lamellipodium; and perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Orthologous to human PTPRM (protein tyrosine phosphatase receptor type M). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in lung adult (RPKM 20.9), heart adult (RPKM 9.9) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 E1.1; 17 37.88 cM
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (66973843..67661486, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (66666848..67354491, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_43079 Neighboring gene STARR-seq mESC enhancer starr_43080 Neighboring gene thymocyte selection associated family member 3 Neighboring gene VISTA enhancer mm1745 Neighboring gene predicted gene, 46576 Neighboring gene RIKEN cDNA 1700016K05 gene Neighboring gene STARR-seq mESC enhancer starr_43082 Neighboring gene STARR-seq mESC enhancer starr_43083 Neighboring gene actin related protein 2/3 complex, subunit 1A pseudogene Neighboring gene STARR-seq mESC enhancer starr_43084 Neighboring gene STARR-seq mESC enhancer starr_43085 Neighboring gene predicted gene, 49940 Neighboring gene STARR-seq mESC enhancer starr_43086 Neighboring gene STARR-seq mESC enhancer starr_43088 Neighboring gene microRNA 5709 Neighboring gene STARR-seq mESC enhancer starr_43089 Neighboring gene STARR-seq mESC enhancer starr_43090 Neighboring gene STARR-seq mESC enhancer starr_43091 Neighboring gene STARR-seq mESC enhancer starr_43092 Neighboring gene predicted gene, 52313 Neighboring gene predicted gene, 36152 Neighboring gene STARR-seq mESC enhancer starr_43094 Neighboring gene STARR-seq mESC enhancer starr_43095 Neighboring gene STARR-seq mESC enhancer starr_43096 Neighboring gene predicted gene, 36201

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of receptor-type protein tyrosine phosphatase μ as a new marker for osteocytes. de Rooij KE, et al. Histochem Cell Biol, 2015 Jul. PMID 25850409, Free PMC Article
    2. Receptor protein tyrosine phosphatase mu expression as a marker for endothelial cell heterogeneity; analysis of RPTPmu gene expression using LacZ knock-in mice. Koop EA, et al. Int J Dev Biol, 2003 Jun. PMID 12895029
    3. RPTPμ tyrosine phosphatase promotes adipogenic differentiation via modulation of p120 catenin phosphorylation. Kim WK, et al. Mol Biol Cell, 2011 Dec. PMID 21998202, Free PMC Article
    4. Impaired flow-induced dilation in mesenteric resistance arteries from receptor protein tyrosine phosphatase-mu-deficient mice. Koop EA, et al. Am J Physiol Heart Circ Physiol, 2005 Mar. PMID 15706045
    5. Differential expression of MAM-subfamily protein tyrosine phosphatases during mouse development. Fuchs M, et al. Mech Dev, 1998 Jan. PMID 9510027

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. histochemical analysis showed that within bone, RPTPmu is expressed exclusively in early-stage osteocytes and therefore is a new marker for osteocytes
      Title: Identification of receptor-type protein tyrosine phosphatase μ as a new marker for osteocytes.
    2. differentiation into adipocytes is controlled by RPTPmu
      Title: RPTPμ tyrosine phosphatase promotes adipogenic differentiation via modulation of p120 catenin phosphorylation.
    3. RPTPmu is involved in the mechanotransduction or accessory signaling pathways that control shear stress responses in mesenteric resistance arteries.
      Title: Impaired flow-induced dilation in mesenteric resistance arteries from receptor protein tyrosine phosphatase-mu-deficient mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA4044, MGC90724

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cadherin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane receptor protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retina layer formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retinal ganglion cell axon guidance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within vasodilation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    receptor-type tyrosine-protein phosphatase mu
    Names
    R-PTP-mu
    protein-tyrosine phosphatase mu
    NP_001344554.1
    NP_033010.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357625.1 → NP_001344554.1  receptor-type tyrosine-protein phosphatase mu isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AK164246, BC079621, BP758008, BP758009
      Consensus CDS
      CCDS89138.1
      UniProtKB/TrEMBL
      Q68FM4
      Related
      ENSMUSP00000045603.10, ENSMUST00000037974.10
      Conserved Domains (6) summary
      smart00060
      Location:383 → 467
      FN3; Fibronectin type 3 domain
      smart00137
      Location:22 → 182
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00194
      Location:933 → 1187
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:1249 → 1481
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      pfam00047
      Location:192 → 274
      ig; Immunoglobulin domain
      pfam00041
      Location:499 → 574
      fn3; Fibronectin type III domain

    2. NM_008984.2 → NP_033010.2  receptor-type tyrosine-protein phosphatase mu precursor

      See identical proteins and their annotated locations for NP_033010.2

      Status: VALIDATED

      Source sequence(s)
      AU254682, BC079621, BP758008, X58287
      Consensus CDS
      CCDS28948.1
      UniProtKB/Swiss-Prot
      E9QKU4, P28828, Q571L8
      Related
      ENSMUSP00000153662.2, ENSMUST00000223982.2
      Conserved Domains (6) summary
      smart00060
      Location:383 → 467
      FN3; Fibronectin type 3 domain
      smart00137
      Location:22 → 182
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      cd14633
      Location:884 → 1156
      R-PTPc-M-1; catalytic domain of receptor-type tyrosine-protein phosphatase M, repeat 1
      cd14635
      Location:1242 → 1447
      R-PTPc-M-2; PTP domain of receptor-type tyrosine-protein phosphatase M, repeat 2
      pfam00041
      Location:499 → 574
      fn3; Fibronectin type III domain
      pfam00047
      Location:192 → 274
      ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      66973843..67661486 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P28828.2 GenPept UniProtKB/Swiss-Prot:P28828

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