Ptp4a3 protein tyrosine phosphatase 4a3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ptp4a3provided by MGI
Official Full Name: protein tyrosine phosphatase 4a3provided by MGI
Primary source: MGI:MGI:1277098
See related: Ensembl:ENSMUSG00000059895 AllianceGenome:MGI:1277098
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Prl-3; pPtp4a3
Summary: Predicted to enable protein tyrosine phosphatase activity. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; positive regulation of vascular permeability; and regulation of vascular endothelial growth factor signaling pathway. Predicted to be located in endosome and plasma membrane. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; liver; metanephros; and retina layer. Orthologous to human PTP4A3 (protein tyrosine phosphatase 4A3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in spleen adult (RPKM 91.4), heart adult (RPKM 60.2) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 D3; 15 34.05 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (73594991..73629075)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (73723145..73758766)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The phosphatase PRL-3 affects intestinal homeostasis by altering the crypt cell composition.
Title: The phosphatase PRL-3 affects intestinal homeostasis by altering the crypt cell composition.
The Oncogenic PRL Protein Causes Acid Addiction of Cells by Stimulating Lysosomal Exocytosis.
Title: The Oncogenic PRL Protein Causes Acid Addiction of Cells by Stimulating Lysosomal Exocytosis.
PRL3 pseudophosphatase activity is necessary and sufficient to promote metastatic growth.
Title: PRL3 pseudophosphatase activity is necessary and sufficient to promote metastatic growth.
chemical and biologic reagents reveal a previously unknown communication between the intracellular PTP4A3 phosphatase and the ECM and support efforts to pharmacologically target PTP4A3.
Title: A chemical genetics approach identifies PTP4A3 as a regulator of colon cancer cell adhesion.
our results suggest that the Prl3b1-cre mice line provides a unique resource to understand testicular germ-cell development
Title: Germline recombination in a novel Cre transgenic line, Prl3b1-Cre mouse.
Results demonstrate that Ptp4a3 contributes to the malignant phenotype of tumor-initiating cells.
Title: Deletion of Ptp4a3 reduces clonogenicity and tumor-initiation ability of colitis-associated cancer cells in mice.
PRL-3 protein was significantly reduced in mouse STAT3-knockout liver cells compared with STAT3-wild type counterparts, and ectopic expression of STAT3 in these cells led to a pronounced increase in PRL-3 protein.
Title: Phosphatase of regenerating liver-3 is regulated by signal transducer and activator of transcription 3 in acute myeloid leukemia.
Data indicate that Mycobacterium tuberculosis T cell stimulatory epitope (MT) is a potentially effective molecular adjuvant in preparation of monoclonal antibody (mAb) specific for phosphatase of regenerating liver-3 (PRL-3).
Title: [Role of molecular adjuvants TBhsp and MT in the preparation of monoclonal antibody against phosphatase of regenerating liver-3].
These findings strongly support a role for PTP4A3 as an important contributor to endothelial cell function and as a multimodal target for cancer therapy and mitigating VEGF-regulated angiogenesis.
Title: Protein-tyrosine phosphatase 4A3 (PTP4A3) promotes vascular endothelial growth factor signaling and enables endothelial cell motility.
the first definitive evidence implicating Ptp4a3 in colon tumorigenesis
Title: Targeted deletion of the metastasis-associated phosphatase Ptp4a3 (PRL-3) suppresses murine colon cancer.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (4) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

AV088979 (e-PCR)
- UniSTS:180771

AU016354 (e-PCR)
- UniSTS:209096

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Notch signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in endothelial cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within endothelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endothelial cell migration	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of establishment of protein localization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of vascular permeability	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of vascular endothelial growth factor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein tyrosine phosphatase type IVA 3

Names: protein-tyrosine phosphatase of regenerating liver 3

NP_001159860.1

EC 3.1.3.48

NP_001159861.1

EC 3.1.3.48

NP_001159862.1

EC 3.1.3.48

NP_001344520.1

EC 3.1.3.48

NP_001398625.1

EC 3.1.3.48

NP_001398626.1

EC 3.1.3.48

NP_001398627.1

EC 3.1.3.48

NP_001398628.1

EC 3.1.3.48

NP_001398629.1

EC 3.1.3.48

NP_033001.2

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001166388.2 → NP_001159860.1 protein tyrosine phosphatase type IVA 3 isoform 1

See identical proteins and their annotated locations for NP_001159860.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC119884

Consensus CDS

CCDS27519.1

UniProtKB/Swiss-Prot

O70275, Q3T9Z5, Q9CTC8, Q9D658

UniProtKB/TrEMBL

Q4FK37

Related

ENSMUSP00000131281.2, ENSMUST00000163582.9

Conserved Domains (1) summary

cl28904
Location:5 → 158

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
NM_001166389.2 → NP_001159861.1 protein tyrosine phosphatase type IVA 3 isoform 1

See identical proteins and their annotated locations for NP_001159861.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) has an alternate 5' UTR exon, as compared to variant 1 has an alternate 5' UTR exon, as compared to variant 1, and encodes isoform 1.

Source sequence(s)

AC119884

Consensus CDS

CCDS27519.1

UniProtKB/Swiss-Prot

O70275, Q3T9Z5, Q9CTC8, Q9D658

UniProtKB/TrEMBL

Q4FK37

Related

ENSMUSP00000132097.2, ENSMUST00000165541.8

Conserved Domains (1) summary

cl28904
Location:5 → 158

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
NM_001166390.2 → NP_001159862.1 protein tyrosine phosphatase type IVA 3 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' sequence, as compared to variant 1. The resulting isoform (2) is shorter and has a distinct N-terminus, as compared to isoform 1.

Source sequence(s)

AC119884

UniProtKB/TrEMBL

E9PXS4, Q4FK37

Related

ENSMUSP00000131036.2, ENSMUST00000167582.8

Conserved Domains (1) summary

cl21483
Location:18 → 154

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
NM_001357591.2 → NP_001344520.1 protein tyrosine phosphatase type IVA 3 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (12) has an alternate 5' UTR exon, as compared to variant 1, and encodes isoform 1.

Source sequence(s)

AC119884

Consensus CDS

CCDS27519.1

UniProtKB/Swiss-Prot

O70275, Q3T9Z5, Q9CTC8, Q9D658

UniProtKB/TrEMBL

Q4FK37

Related

ENSMUSP00000154829.2, ENSMUST00000230177.2

Conserved Domains (1) summary

cl28904
Location:5 → 158

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
NM_001411696.1 → NP_001398625.1 protein tyrosine phosphatase type IVA 3 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (10) has an alternate 5' UTR exon, as compared to variant 1, and encodes isoform 1.

Source sequence(s)

AC119884

UniProtKB/Swiss-Prot

O70275, Q3T9Z5, Q9CTC8, Q9D658
NM_001411697.1 → NP_001398626.1 protein tyrosine phosphatase type IVA 3 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (9) has an alternate 5' UTR exon, as compared to variant 1, and encodes isoform 1.

Source sequence(s)

AC119884

UniProtKB/Swiss-Prot

O70275, Q3T9Z5, Q9CTC8, Q9D658
NM_001411698.1 → NP_001398627.1 protein tyrosine phosphatase type IVA 3 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (8) has an alternate 5' UTR exon, as compared to variant 1, and encodes isoform 1.

Source sequence(s)

AC119884

UniProtKB/Swiss-Prot

O70275, Q3T9Z5, Q9CTC8, Q9D658
NM_001411699.1 → NP_001398628.1 protein tyrosine phosphatase type IVA 3 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (7) has an alternate 5' UTR exon, as compared to variant 1, and encodes isoform 1.

Source sequence(s)

AC119884

UniProtKB/Swiss-Prot

O70275, Q3T9Z5, Q9CTC8, Q9D658
NM_001411700.1 → NP_001398629.1 protein tyrosine phosphatase type IVA 3 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (6) has an alternate 5' UTR exon, as compared to variant 1, and encodes isoform 1.

Source sequence(s)

AC119884

UniProtKB/Swiss-Prot

O70275, Q3T9Z5, Q9CTC8, Q9D658
NM_008975.4 → NP_033001.2 protein tyrosine phosphatase type IVA 3 isoform 1

See identical proteins and their annotated locations for NP_033001.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) has an alternate 5' UTR exon, as compared to variant 1, and encodes isoform 1.

Source sequence(s)

AC119884

Consensus CDS

CCDS27519.1

UniProtKB/Swiss-Prot

O70275, Q3T9Z5, Q9CTC8, Q9D658

UniProtKB/TrEMBL

Q4FK37

Related

ENSMUSP00000060956.7, ENSMUST00000053232.8

Conserved Domains (1) summary

cl28904
Location:5 → 158

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

RNA

NR_177452.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (11) has an alternate 5' UTR exon and skips an internal exon, as compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.

Source sequence(s)

AC119884