Wfdc12 WAP four-disulfide core domain 12 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wfdc12provided by MGI
Official Full Name: WAP four-disulfide core domain 12provided by MGI
Primary source: MGI:MGI:2183434
See related: Ensembl:ENSMUSG00000042845 AllianceGenome:MGI:2183434
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: WAP2; Swam2
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Involved in defense response to bacterium. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human WFDC12 (WAP four-disulfide core domain 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in stomach adult (RPKM 1.2), lung adult (RPKM 0.8) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H3; 2 84.6 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (164031151..164032528, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (164189231..164190558, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A role for whey acidic protein four-disulfide-core 12 (WFDC12) in the pathogenesis and development of psoriasis disease.
Title: A role for whey acidic protein four-disulfide-core 12 (WFDC12) in the pathogenesis and development of psoriasis disease.
The antibacterial protein SWAM2 is constitutively expressed in tongue and inhibits the growth of both Escherichia coli and Staphylococcus aureus at an IC90 of 10 microM.
Title: Mouse SWAM1 and SWAM2 are antibacterial proteins composed of a single whey acidic protein motif.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables peptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in antibacterial humoral response	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: WAP four-disulfide core domain protein 12

Names: elafin-like protein II; single WAP motif protein 2; whey acidic protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138684.3 → NP_619625.1 WAP four-disulfide core domain protein 12 precursor

See identical proteins and their annotated locations for NP_619625.1

Status: VALIDATED

Source sequence(s)

AL591512

Consensus CDS

CCDS38318.1

UniProtKB/Swiss-Prot

Q9JHY3

UniProtKB/TrEMBL

Q3V469

Related

ENSMUSP00000050836.8, ENSMUST00000051272.8

Conserved Domains (1) summary

pfam00095
Location:31 → 71

WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'