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    Nadk NAD kinase [ Mus musculus (house mouse) ]

    Gene ID: 192185, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Nadkprovided by MGI
    Official Full Name
    NAD kinaseprovided by MGI
    Primary source
    MGI:MGI:2183149
    See related
    Ensembl:ENSMUSG00000029063 AllianceGenome:MGI:2183149
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4432404C02Rik
    Summary
    Predicted to enable NAD+ kinase activity. Predicted to be involved in NADP biosynthetic process and positive regulation of insulin secretion involved in cellular response to glucose stimulus. Predicted to be located in cytosol. Orthologous to human NADK (NAD kinase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 138.3), liver adult (RPKM 72.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 E2; 4 86.44 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (155646838..155675458)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (155562381..155591001)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12263 Neighboring gene transmembrane protein 52 Neighboring gene guanine nucleotide binding protein (G protein), beta 1 Neighboring gene NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 pseudogene Neighboring gene STARR-seq mESC enhancer starr_12266 Neighboring gene STARR-positive B cell enhancer ABC_E340 Neighboring gene STARR-positive B cell enhancer ABC_E10296 Neighboring gene STARR-positive B cell enhancer ABC_E3559 Neighboring gene solute carrier family 35, member E2 Neighboring gene predicted gene 16023 Neighboring gene cyclin dependent kinase 11B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Structural and functional characterization of human NAD kinase. Lerner F, et al. Biochem Biophys Res Commun, 2001 Oct 19. PMID 11594753
    2. Cloning of mid-G1 serum response genes and identification of a subset regulated by conditional myc expression. Tavtigian SV, et al. Mol Biol Cell, 1994 Mar. PMID 8049528, Free PMC Article
    3. A STUB1 ubiquitin ligase/CHIC2 protein complex negatively regulates the IL-3, IL-5, and GM-CSF cytokine receptor common β chain (CSF2RB) protein stability. Koochaki SHJ, et al. J Biol Chem, 2022 Oct. PMID 36108743, Free PMC Article
    4. The human (PEDB) and mouse (mPEDB) Prostate Expression Databases. Nelson PS, et al. Nucleic Acids Res, 2002 Jan 1. PMID 11752298, Free PMC Article
    5. LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow. Tseng HY, et al. J Cell Sci, 2018 Nov 21. PMID 30333137, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 
    • Endonuclease-mediated (6) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC7589

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD+ kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD+ kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NAD+ kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in NAD metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in NADP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in NADP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NAD kinase
    Names
    Putative inorganic polyphosphate/ATP-NAD kinase (Poly(P)/ATP NAD kinase)
    poly(P)/ATP NAD kinase
    NP_001153109.1
    NP_001342528.1
    NP_619612.2
    XP_006538725.1
    XP_006538726.1
    XP_006538728.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159637.1 → NP_001153109.1  NAD kinase isoform 1

      See identical proteins and their annotated locations for NP_001153109.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AA197692, AK147917, AW455445, BE950056, BF453238, BF682935, CJ166231
      Consensus CDS
      CCDS19031.1
      UniProtKB/Swiss-Prot
      P58058, Q3TCP7
      UniProtKB/TrEMBL
      Q3TN62, Q3UGI1
      Related
      ENSMUSP00000101238.4, ENSMUST00000105613.10
      Conserved Domains (1) summary
      cl28462
      Location:96 → 429
      pnk; bifunctional NADP phosphatase/NAD kinase

    2. NM_001355599.1 → NP_001342528.1  NAD kinase isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AK147917, BB869695, BE950056, BP767626, BY202795, CF916286, CK334104, DV043414
      UniProtKB/TrEMBL
      A2A9P2
      Related
      ENSMUSP00000101237.2, ENSMUST00000105612.2
      Conserved Domains (1) summary
      cl28462
      Location:9 → 342
      pnk; inorganic polyphosphate/ATP-NAD kinase; Provisional

    3. NM_138671.3 → NP_619612.2  NAD kinase isoform 1

      See identical proteins and their annotated locations for NP_619612.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK147917, BE950056, BP767626, BY154310, CF916286, CK334104, DV043414
      Consensus CDS
      CCDS19031.1
      UniProtKB/Swiss-Prot
      P58058, Q3TCP7
      UniProtKB/TrEMBL
      Q3TN62, Q3UGI1
      Related
      ENSMUSP00000030939.8, ENSMUST00000030939.14
      Conserved Domains (1) summary
      cl28462
      Location:96 → 429
      pnk; bifunctional NADP phosphatase/NAD kinase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      155646838..155675458
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538665.4 → XP_006538728.1  NAD kinase isoform X2

      Conserved Domains (1) summary
      cl01255
      Location:98 → 310
      DAGK_cat; Diacylglycerol kinase catalytic domain

    2. XM_006538662.5 → XP_006538725.1  NAD kinase isoform X1

      See identical proteins and their annotated locations for XP_006538725.1

      UniProtKB/Swiss-Prot
      P58058, Q3TCP7
      UniProtKB/TrEMBL
      Q3TN62, Q3UGI1
      Conserved Domains (1) summary
      cl28462
      Location:96 → 429
      pnk; bifunctional NADP phosphatase/NAD kinase

    3. XM_006538663.5 → XP_006538726.1  NAD kinase isoform X1

      See identical proteins and their annotated locations for XP_006538726.1

      UniProtKB/Swiss-Prot
      P58058, Q3TCP7
      UniProtKB/TrEMBL
      Q3TN62, Q3UGI1
      Conserved Domains (1) summary
      cl28462
      Location:96 → 429
      pnk; bifunctional NADP phosphatase/NAD kinase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P58058.2 GenPept UniProtKB/Swiss-Prot:P58058

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