Ptger2 prostaglandin E receptor 2 (subtype EP2) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ptger2provided by MGI
Official Full Name: prostaglandin E receptor 2 (subtype EP2)provided by MGI
Primary source: MGI:MGI:97794
See related: Ensembl:ENSMUSG00000037759 AllianceGenome:MGI:97794
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: EP2; Ptgerep2
Summary: Predicted to enable prostaglandin E receptor activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; cellular response to prostaglandin E stimulus; and response to progesterone. Acts upstream of or within regulation of cell population proliferation and response to lipopolysaccharide. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system; gut; hemolymphoid system gland; liver and biliary system; and reproductive system. Human ortholog(s) of this gene implicated in asthma, nasal polyps, and aspirin intolerance. Orthologous to human PTGER2 (prostaglandin E receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in ovary adult (RPKM 4.1), lung adult (RPKM 2.0) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 C1; 14 22.68 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (45225568..45241277)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (44988111..45003820)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TT-10 may elevate YAP and repair mouse uterine damage resulting from the inhibition effect of ibuprofen on COX2-PGE2 and YAP.
Title: TT-10 may elevate YAP and repair mouse uterine damage resulting from the inhibition effect of ibuprofen on COX2-PGE2 and YAP.
Increased COX-2 after ureter obstruction attenuates fibrosis and is associated with EP2 receptor upregulation in mouse and human kidney.
Title: Increased COX-2 after ureter obstruction attenuates fibrosis and is associated with EP(2) receptor upregulation in mouse and human kidney.
Reduced tumor growth in EP2 knockout mice is related to signaling pathways favoring an increased local antitumor immunity in the tumor stroma.
Title: Reduced tumor growth in EP2 knockout mice is related to signaling pathways favoring an increased local anti‑tumor immunity in the tumor stroma.
Prostaglandin E2-Induced AKT Activation Regulates the Life Span of Short-Lived Plasma Cells by Attenuating IRE1alpha Hyperactivation.
Title: Prostaglandin E(2)-Induced AKT Activation Regulates the Life Span of Short-Lived Plasma Cells by Attenuating IRE1α Hyperactivation.
Intact prostaglandin signaling through EP2 and EP4 receptors in stromal progenitor cells is required for normal development of the renal cortex in mice.
Title: Intact prostaglandin signaling through EP2 and EP4 receptors in stromal progenitor cells is required for normal development of the renal cortex in mice.
Involvement of TLR4 signaling regulated-COX2/PGE2 axis in liver fibrosis induced by Schistosoma japonicum infection.
Title: Involvement of TLR4 signaling regulated-COX2/PGE2 axis in liver fibrosis induced by Schistosoma japonicum infection.
PGE2 accounts for bidirectional changes in alveolar macrophage self-renewal with aging and smoking.
Title: PGE(2) accounts for bidirectional changes in alveolar macrophage self-renewal with aging and smoking.
Peripheral Myeloid Cell EP2 Activation Contributes to the Deleterious Consequences of Status Epilepticus.
Title: Peripheral Myeloid Cell EP2 Activation Contributes to the Deleterious Consequences of Status Epilepticus.
Small-molecule inhibition of prostaglandin E receptor 2 impairs cyclooxygenase-associated malignant glioma growth.
Title: Small-molecule inhibition of prostaglandin E receptor 2 impairs cyclooxygenase-associated malignant glioma growth.
this study shows that T cell-intrinsic prostaglandin E2-EP2/EP4 signaling is critical in pathogenic TH17 cell-driven inflammation in psoriasis
Title: T cell-intrinsic prostaglandin E(2)-EP2/EP4 signaling is critical in pathogenic T(H)17 cell-driven inflammation.

Submit: New GeneRIF Correction See all GeneRIFs (98)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (9) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

PMC209534P2 (e-PCR)
- UniSTS:272002

Ptger2 (e-PCR), detects polymorphism
- UniSTS:144291

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables prostaglandin E receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables prostaglandin E receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to prostaglandin E stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to prostaglandin E stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within interleukin-33 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of gastric mucosal blood circulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to nematode	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to progesterone	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: prostaglandin E2 receptor EP2 subtype

Names: EP2 receptor; PGE receptor EP2 subtype; PGE2 receptor EP2 subtype; prostaglandin E receptor 2 (EP2 subtype); prostaglandin E receptor EP2 subtype; prostaglandin E receptor subtype EP2; prostanoid EP2 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008964.4 → NP_032990.1 prostaglandin E2 receptor EP2 subtype

See identical proteins and their annotated locations for NP_032990.1

Status: VALIDATED

Source sequence(s)

AC154627, AK054132, BG086577

Consensus CDS

CCDS26972.1

UniProtKB/Swiss-Prot

Q62053

UniProtKB/TrEMBL

Q3UW60, Q543A9

Related

ENSMUSP00000038483.6, ENSMUST00000046891.6

Conserved Domains (1) summary

pfam00001
Location:39 → 314

7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

45225568..45241277

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006518720.5 → XP_006518783.1 prostaglandin E2 receptor EP2 subtype isoform X1

UniProtKB/TrEMBL

Q8BZ75

Conserved Domains (2) summary

cd14964
Location:24 → 50

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:23 → 281

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily