Atp12a ATPase, H+/K+ transporting, nongastric, alpha polypeptide [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Atp12aprovided by MGI
Official Full Name: ATPase, H+/K+ transporting, nongastric, alpha polypeptideprovided by MGI
Primary source: MGI:MGI:1926943
See related: Ensembl:ENSMUSG00000022229 AllianceGenome:MGI:1926943
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: cHKA; Atp1al1; HKalpha2
Summary: Predicted to enable P-type potassium:proton transporter activity and P-type sodium:potassium-exchanging transporter activity. Acts upstream of or within potassium ion homeostasis and regulation of pH. Located in basolateral plasma membrane. Is expressed in several structures, including gut; metanephros; pituitary gland; reproductive system; and thymus. Orthologous to human ATP12A (ATPase H+/K+ transporting non-gastric alpha2 subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward colon adult (RPKM 53.7) See more
Orthologs: human all
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Genomic context

Location:: 14 C3; 14 28.19 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (56602525..56626008)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (56364669..56388551)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

H,K-ATPase type 2 regulates renal salt and potassium metabolism during gestation, controlling plasma volume expansion and blood pressure.
Title: H,K-ATPase type 2 regulates gestational extracellular compartment expansion and blood pressure in mice.
After 4 days of K+ restriction HKA2 KO mice exhibit hypokalemia and hypotension.
Title: H,K-ATPase type 2 contributes to salt-sensitive hypertension induced by K(+) restriction.
HKA2-null mice did not accumulate K(+) in their extracellular compartment.
Title: A link between fertility and K+ homeostasis: role of the renal H,K-ATPase type 2.
HKA2-null mice fed a normal diet have 2-fold higher K(+) renal excretion during rest. Under K(+) restriction, their urinary K(+) loss is 40% higher during the activity period.
Title: Circadian expression of H,K-ATPase type 2 contributes to the stability of plasma K⁺ levels.
Sp1 plays an important and positive role in controlling basal HKalpha2 gene expression in murine inner medullary collecting duct cells in vivo and in vitro.
Title: Sp1 trans-activates the murine H(+)-K(+)-ATPase alpha(2)-subunit gene.
Both HKalpha(1) and HKalpha(2) contribute to proton secretion in both A-type and B-type intercalated cells in animals fed a normal diet.
Title: Impaired acid secretion in cortical collecting duct intercalated cells from H-K-ATPase-deficient mice: role of HKalpha isoforms.
kappaB DNA binding element at -104 to -94 influences basal HKalpha(2) gene transcription in kidney collecting duct cells
Title: NF-kappaB inhibits transcription of the H(+)-K(+)-ATPase alpha(2)-subunit gene: role of histone deacetylases.
These results show that nongastric H-K-ATPase is required for acidification of luminal prostate fluids, thereby providing a strong in vivo correlate of previous functional expression studies demonstrating that it operates as a proton pump.
Title: Loss of acidification of anterior prostate fluids in Atp12a-null mutant mice indicates that nongastric H-K-ATPase functions as proton pump in vivo.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables P-type potassium transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
contributes_to P-type potassium:proton transporter activity	ISO Inferred from Sequence Orthology more info
enables P-type potassium:proton transporter activity	ISO Inferred from Sequence Orthology more info
enables P-type sodium:potassium-exchanging transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables P-type sodium:potassium-exchanging transporter activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in intracellular potassium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular sodium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within potassium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in proton transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of pH	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to metal ion	ISO Inferred from Sequence Orthology more info
involved_in response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
involved_in sodium ion export across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sodium ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: potassium-transporting ATPase alpha chain 2

Names: ATPase H+K+-transporting, alpha 2; HK alpha 2; non-gastric H(+)/K(+) ATPase subunit alpha; non-gastric Na(+)/K(+) ATPase subunit alpha; proton pump; sodium pump

NP_619593.2

EC 7.2.2.13

EC 7.2.2.19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138652.2 → NP_619593.2 potassium-transporting ATPase alpha chain 2

See identical proteins and their annotated locations for NP_619593.2

Status: VALIDATED

Source sequence(s)

BC109011, BY663985

Consensus CDS

CCDS27148.1

UniProtKB/Swiss-Prot

Q32MR8, Q8VHY2, Q9Z1W8

Related

ENSMUSP00000007340.3, ENSMUST00000007340.4

Conserved Domains (1) summary

TIGR01106
Location:40 → 1035

ATPase-IIC_X-K; sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit