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    Pstpip2 proline-serine-threonine phosphatase-interacting protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 19201, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Pstpip2provided by MGI
    Official Full Name
    proline-serine-threonine phosphatase-interacting protein 2provided by MGI
    Primary source
    MGI:MGI:1335088
    See related
    Ensembl:ENSMUSG00000025429 AllianceGenome:MGI:1335088
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    cmo; MAYP
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in actin filament polymerization. Located in cytoskeleton; cytosol; and membrane. Orthologous to human PSTPIP2 (proline-serine-threonine phosphatase interacting protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 9.6), small intestine adult (RPKM 8.3) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    18 E3; 18 52.38 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (77882250..77971462)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (77794550..77882879)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_45130 Neighboring gene HAUS augmin-like complex, subunit 1 Neighboring gene predicted gene, 52331 Neighboring gene STARR-seq mESC enhancer starr_45133 Neighboring gene RIKEN cDNA F830208F22 gene Neighboring gene ATP synthase F1 subunit alpha Neighboring gene STARR-positive B cell enhancer mm9_chr18:78030749-78031049 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:78061325-78061621 Neighboring gene STARR-positive B cell enhancer ABC_E2514 Neighboring gene ectopic P-granules 5 autophagy tethering factor Neighboring gene sialic acid binding Ig-like lectin 15

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular interactions of adaptor protein PSTPIP2 control neutrophil-mediated responses leading to autoinflammation. Pavliuchenko N, et al. Front Immunol, 2022. PMID 36605205, Free PMC Article
    2. PSTPIP2 regulates synovial macrophages polarization and dynamics via ERβ in the joint microenvironment. Yao Y, et al. Arthritis Res Ther, 2022 Nov 2. PMID 36324152, Free PMC Article
    3. PSTPIP2 connects DNA methylation to macrophage polarization in CCL4-induced mouse model of hepatic fibrosis. Yang Y, et al. Oncogene, 2018 Nov. PMID 29993036
    4. Increased neutrophil infiltration, IL-1 production and a SAPHO syndrome-like phenotype in PSTPIP2-deficient mice. Liao HJ, et al. Rheumatology (Oxford), 2015 Jul. PMID 25602062
    5. PSTPIP2 deficiency in mice causes osteopenia and increased differentiation of multipotent myeloid precursors into osteoclasts. Chitu V, et al. Blood, 2012 Oct 11. PMID 22923495, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PSTPIP2 alleviates obesity associated adipose tissue inflammation and insulin resistance in diabetes mice through promoting M2 macrophage polarization via activation of PPARgamma.
      Title: PSTPIP2 alleviates obesity associated adipose tissue inflammation and insulin resistance in diabetes mice through promoting M2 macrophage polarization via activation of PPARγ.
    2. Molecular interactions of adaptor protein PSTPIP2 control neutrophil-mediated responses leading to autoinflammation.
      Title: Molecular interactions of adaptor protein PSTPIP2 control neutrophil-mediated responses leading to autoinflammation.
    3. PSTPIP2 regulates synovial macrophages polarization and dynamics via ERbeta in the joint microenvironment.
      Title: PSTPIP2 regulates synovial macrophages polarization and dynamics via ERβ in the joint microenvironment.
    4. Dysregulated NADPH Oxidase Promotes Bone Damage in Murine Model of Autoinflammatory Osteomyelitis.
      Title: Dysregulated NADPH Oxidase Promotes Bone Damage in Murine Model of Autoinflammatory Osteomyelitis.
    5. Knockdown of PSTPIP2 promoted M1 polarization and suppressed M2 polarization in vitro.
      Title: PSTPIP2 connects DNA methylation to macrophage polarization in CCL4-induced mouse model of hepatic fibrosis.
    6. a new PSTPIP1/PTPN6/SHIP1/2-dependent negative feedback mechanism that counterbalances Src and PI(3,4,5)P3 signalling to control osteoclast cell polarity and activity during bone resorption
      Title: BAR Proteins PSTPIP1/2 Regulate Podosome Dynamics and the Resorption Activity of Osteoclasts.
    7. SHIP1 and Csk are part of the PSTPIP2-dependent inhibitory network that prevents the development of autoinflammatory disease.
      Title: PSTPIP2, a Protein Associated with Autoinflammatory Disease, Interacts with Inhibitory Enzymes SHIP1 and Csk.
    8. PSTPIP2 could play a role in innate immunity and development of autoinflammatory bone disorders, and may be associated with the pathogenesis of SAPHO syndrome.
      Title: Increased neutrophil infiltration, IL-1 production and a SAPHO syndrome-like phenotype in PSTPIP2-deficient mice.
    9. IL-1beta has a role in mediating autoinflammatory disease in Pstpip2-deficient mice
      Title: Inflammasome-independent IL-1β mediates autoinflammatory disease in Pstpip2-deficient mice.
    10. inflammasome-independent production of IL-1beta has a critical role in osteolytic bone disease; PSTPIP2 is a negative regulator of caspase-1-autonomous IL-1beta production
      Title: Critical role for inflammasome-independent IL-1β production in osteomyelitis.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Phenotypes

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    Associated conditions

    Description Tests
    chronic multifocal osteomyelitis
    GeneReviews: Not available

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoskeleton organization NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    proline-serine-threonine phosphatase-interacting protein 2
    Names
    PEST phosphatase-interacting protein 2
    macrophage actin-associated tyrosine-phosphorylated protein
    pp37

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013831.4 → NP_038859.3  proline-serine-threonine phosphatase-interacting protein 2

      See identical proteins and their annotated locations for NP_038859.3

      Status: VALIDATED

      Source sequence(s)
      AC157649, AK132418, AK157994, BY194204
      Consensus CDS
      CCDS37868.1
      UniProtKB/Swiss-Prot
      Q6GTF6, Q99M15, Q9Z189
      UniProtKB/TrEMBL
      Q3U4E4
      Related
      ENSMUSP00000110389.3, ENSMUST00000114741.4
      Conserved Domains (1) summary
      cd07672
      Location:15 → 254
      F-BAR_PSTPIP2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Proline-Serine-Threonine Phosphatase-Interacting Protein 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      77882250..77971462
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161032.1 → XP_036016925.1  proline-serine-threonine phosphatase-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q6GTF6, Q99M15, Q9Z189
      UniProtKB/TrEMBL
      Q3U4E4
      Conserved Domains (1) summary
      cd07672
      Location:15 → 254
      F-BAR_PSTPIP2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Proline-Serine-Threonine Phosphatase-Interacting Protein 2

    2. XM_036161033.1 → XP_036016926.1  proline-serine-threonine phosphatase-interacting protein 2 isoform X2

      Conserved Domains (1) summary
      cl12013
      Location:15 → 247
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    3. XM_036161034.1 → XP_036016927.1  proline-serine-threonine phosphatase-interacting protein 2 isoform X3

      Conserved Domains (1) summary
      cd07672
      Location:15 → 247
      F-BAR_PSTPIP2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Proline-Serine-Threonine Phosphatase-Interacting Protein 2

    4. XM_036161035.1 → XP_036016928.1  proline-serine-threonine phosphatase-interacting protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A494BAM6
      Related
      ENSMUSP00000158158.2, ENSMUST00000238172.2
      Conserved Domains (1) summary
      cl12013
      Location:1 → 150
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_177831.2: Suppressed sequence

      Description
      NM_177831.2: This RefSeq was suppressed because it overlaps with, and potentially represents a 5' extension of, NM_013831.3 of the Pstpip2 gene.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99M15.4 GenPept UniProtKB/Swiss-Prot:Q99M15

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