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    Prl7a1 prolactin family 7, subfamily a, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 19113, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Prl7a1provided by MGI
    Official Full Name
    prolactin family 7, subfamily a, member 1provided by MGI
    Primary source
    MGI:MGI:1206572
    See related
    Ensembl:ENSMUSG00000006488 AllianceGenome:MGI:1206572
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PLP-E; PLP-G; Prlpe; Prlpg
    Summary
    Predicted to enable hormone activity and prolactin receptor binding activity. Predicted to be involved in several processes, including positive regulation of lactation; positive regulation of pri-miRNA transcription by RNA polymerase II; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in extraembryonic component; labyrinthine zone; and placenta. Human ortholog(s) of this gene implicated in carotid artery disease. Orthologous to human PRL (prolactin). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward placenta adult (RPKM 658.2) See more
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    Genomic context

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    Location:
    13 A3.1; 13 12.56 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (27817347..27826476, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (27633364..27642493, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene prolactin family 8, subfamily a, member 1 Neighboring gene STARR-seq mESC enhancer starr_34016 Neighboring gene prolactin family 7, subfamily b, member 1 Neighboring gene prolactin family 7, subfamily a, member 2 Neighboring gene prolactin pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Enhanced recovery from thrombocytopenia and neutropenia in mice constitutively expressing a placental hematopoietic cytokine. Zhou B, et al. Endocrinology, 2005 Jan. PMID 15375031
    2. Reactivation of a hematopoietic endocrine program of pregnancy contributes to recovery from thrombocytopenia. Bhattacharyya S, et al. Mol Endocrinol, 2002 Jun. PMID 12040023
    3. Two placental hormones are agonists in stimulating megakaryocyte growth and differentiation. Zhou B, et al. Endocrinology, 2002 Nov. PMID 12399423
    4. Identification of two new members of the mouse prolactin gene family. Müller H, et al. Biochim Biophys Acta, 1998 Mar 13. PMID 9545574
    5. Two novel members of the prolactin/growth hormone family are expressed in the mouse placenta. Lin J, et al. Endocrinology, 1997 Dec. PMID 9389541

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. injection of PLP-E into thrombocytopenic mice restores normal platelet levels with no effect on granulocytes, erythrocytes, and total white blood cell counts
      Title: Reactivation of a hematopoietic endocrine program of pregnancy contributes to recovery from thrombocytopenia.
    2. results show that PRL-like proteins E and F have the same stimulatory effects on megakaryocyte growth and differentiation
      Title: Two placental hormones are agonists in stimulating megakaryocyte growth and differentiation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables prolactin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in female pregnancy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mammary gland development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of lactation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of receptor signaling pathway via JAK-STAT IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to nutrient levels IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    prolactin-7A1
    Names
    PRL-like protein E
    PRL-like protein G
    placental prolactin-like protein E
    placental prolactin-like protein G
    prolactin-like protein E
    prolactin-like protein G

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164058.1 → NP_001157530.1  prolactin-7A1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001157530.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AF011381, AK146050, BC051671
      Consensus CDS
      CCDS49224.1
      UniProtKB/Swiss-Prot
      O35334, O54830, Q80X21
      Related
      ENSMUSP00000093614.4, ENSMUST00000095924.11
      Conserved Domains (1) summary
      cd10288
      Location:31 → 255
      prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

    2. NM_008930.2 → NP_032956.1  prolactin-7A1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_032956.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (2) lacks one internal residue, compared to isoform 1.
      Source sequence(s)
      AF011381, BB611867, BC051671
      Consensus CDS
      CCDS26403.1
      UniProtKB/Swiss-Prot
      O54830
      Related
      ENSMUSP00000006659.7, ENSMUST00000006659.8
      Conserved Domains (1) summary
      cd10288
      Location:30 → 254
      prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      27817347..27826476 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O54830.2 GenPept UniProtKB/Swiss-Prot:O54830

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