U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Prl8a6 prolactin family 8, subfamily a, member 6 [ Mus musculus (house mouse) ]

    Gene ID: 19112, updated on 11-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Prl8a6provided by MGI
    Official Full Name
    prolactin family 8, subfamily a, member 6provided by MGI
    Primary source
    MGI:MGI:1332225
    See related
    Ensembl:ENSMUSG00000021345 AllianceGenome:MGI:1332225
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ghd13; Prlpc; PLP-C1; PLP-Ca; Prlpc1; PLP-calpha
    Summary
    Predicted to enable hormone activity and prolactin receptor binding activity. Predicted to be involved in several processes, including positive regulation of lactation; positive regulation of pri-miRNA transcription by RNA polymerase II; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in extraembryonic component and placenta. Human ortholog(s) of this gene implicated in carotid artery disease. Orthologous to human PRL (prolactin). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward placenta adult (RPKM 6.8) See more
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Prl8a6 in Genome Data Viewer
    Location:
    13 A3.1; 13 12.45 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (27616664..27622671, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (27432681..27438688, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene prolactin family 8, subfamily a, member 2 Neighboring gene STARR-seq mESC enhancer starr_34015 Neighboring gene prolactin family 2, subfamily b, member 1 Neighboring gene predicted gene, 40836 Neighboring gene prolactin family 8, subfamily a, member 81 Neighboring gene prolactin family8, subfamily a, member 9

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Molecular evolution of prolactin gene family in rodents. Li Y, et al. Yi Chuan Xue Bao, 2006 Jul. PMID 16875316
    2. A new member of the mouse prolactin (PRL)-like protein-C subfamily, PRL-like protein-C alpha: structure and expression. Dai G, et al. Endocrinology, 1998 Dec. PMID 9832456
    3. The mouse prolactin gene family locus. Wiemers DO, et al. Endocrinology, 2003 Jan. PMID 12488360
    4. Bridging sequence diversity and tissue-specific expression by DNA methylation in genes of the mouse prolactin superfamily. Hayakawa K, et al. Mamm Genome, 2012 Jun. PMID 22193412, Free PMC Article
    5. The imprinted Phlda2 gene modulates a major endocrine compartment of the placenta to regulate placental demands for maternal resources. Tunster SJ, et al. Dev Biol, 2016 Jan 1. PMID 26476147, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables prolactin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor binding ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in female pregnancy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mammary gland development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of lactation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of receptor signaling pathway via JAK-STAT IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to nutrient levels IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    prolactin-8A6
    Names
    PRL-like protein C1
    growth hormone d13
    placental prolactin-like protein C1
    prolactin-like protein C 1
    prolactin-like protein C-alpha

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271378.1 → NP_001258307.1  prolactin-8A6 isoform a precursor

      See identical proteins and their annotated locations for NP_001258307.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AK005435, AK005478
      Consensus CDS
      CCDS70442.1
      UniProtKB/Swiss-Prot
      Q9DAW0, Q9DAY2, Q9Z249
      UniProtKB/TrEMBL
      A0A0M6L0X0
      Related
      ENSMUSP00000105984.3, ENSMUST00000110355.10
      Conserved Domains (1) summary
      cd10288
      Location:34 → 224
      prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

    2. NM_001271379.1 → NP_001258308.1  prolactin-8A6 isoform c precursor

      See identical proteins and their annotated locations for NP_001258308.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
      Source sequence(s)
      AK005478
      Consensus CDS
      CCDS70441.1
      UniProtKB/Swiss-Prot
      Q9DAY2
      Related
      ENSMUSP00000079584.6, ENSMUST00000080762.12
      Conserved Domains (1) summary
      cl07831
      Location:34 → 189
      growth_hormone_like; Somatotropin/prolactin hormone family

    3. NM_011167.3 → NP_035297.1  prolactin-8A6 isoform b precursor

      See identical proteins and their annotated locations for NP_035297.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
      Source sequence(s)
      AK005435, AK005478
      Consensus CDS
      CCDS26398.1
      UniProtKB/Swiss-Prot
      Q9DAY2
      Related
      ENSMUSP00000018392.8, ENSMUST00000018392.9
      Conserved Domains (1) summary
      cd10288
      Location:33 → 223
      prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

    RNA

    1. NR_073166.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site at an internal exon, compared to variant 1. This variant is represented as non-coding because it lacks most of the in-frame ORF found in variant 1.
      Source sequence(s)
      AK005435, AK005478, AL592443

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      27616664..27622671 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DAY2.1 GenPept UniProtKB/Swiss-Prot:Q9DAY2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous