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    Prl6a1 prolactin family 6, subfamily a, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 19111, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Prl6a1provided by MGI
    Official Full Name
    prolactin family 6, subfamily a, member 1provided by MGI
    Primary source
    MGI:MGI:1206579
    See related
    Ensembl:ENSMUSG00000069259 AllianceGenome:MGI:1206579
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ghd10; PLP-B; Prlpb
    Summary
    Predicted to enable hormone activity and prolactin receptor binding activity. Predicted to be involved in several processes, including positive regulation of lactation; positive regulation of pri-miRNA transcription by RNA polymerase II; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in decidua; ectoplacental cone; extraembryonic component; and placenta. Human ortholog(s) of this gene implicated in carotid artery disease. Orthologous to human PRL (prolactin). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward placenta adult (RPKM 66.5) See more
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    Genomic context

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    See Prl6a1 in Genome Data Viewer
    Location:
    13 A3.1; 13 12.39 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (27496598..27503237)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (27312615..27319254)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene prolactin family 3, subfamily b, member 1 Neighboring gene prolactin family 3, subfamily a, member 1 Neighboring gene craniofacial development protein 1 pseudogene Neighboring gene prolactin family 8, subfamily a, member 2 Neighboring gene STARR-seq mESC enhancer starr_34015 Neighboring gene prolactin family 2, subfamily b, member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Homologues for prolactin-like proteins A and B are present in the mouse. Müller H, et al. Biol Reprod, 1998 Jan. PMID 9472921
    2. Expression of mouse 17beta-hydroxysteroid dehydrogenase/17-ketosteroid reductase type 7 in the ovary, uterus, and placenta: localization from implantation to late pregnancy. Nokelainen P, et al. Endocrinology, 2000 Feb. PMID 10650959
    3. Three new members of the mouse prolactin/growth hormone family are homologous to proteins expressed in the rat. Lin J, et al. Endocrinology, 1997 Dec. PMID 9389542
    4. Two novel members of the prolactin/growth hormone family are expressed in the mouse placenta. Lin J, et al. Endocrinology, 1997 Dec. PMID 9389541
    5. miR-126 regulates glycogen trophoblast proliferation and DNA methylation in the murine placenta. Sharma A, et al. Dev Biol, 2019 May 1. PMID 30771304, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables prolactin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in female pregnancy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mammary gland development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of lactation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of receptor signaling pathway via JAK-STAT IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to nutrient levels IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    prolactin-6A1
    Names
    PRL-like protein B
    growth hormone d10
    placental prolactin-like protein B
    prolactin-like protein B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001382844.1 → NP_001369773.1  prolactin-6A1 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AL592443
      UniProtKB/TrEMBL
      Q5SXJ8
      Conserved Domains (1) summary
      cd10288
      Location:29 → 229
      prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

    2. NM_011166.2 → NP_035296.1  prolactin-6A1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_035296.1

      Status: VALIDATED

      Source sequence(s)
      AF015563
      Consensus CDS
      CCDS26395.1
      UniProtKB/Swiss-Prot
      O35257
      UniProtKB/TrEMBL
      A0A0M6L0L9, Q5SXJ8
      Related
      ENSMUSP00000089269.3, ENSMUST00000091680.9
      Conserved Domains (1) summary
      cd10288
      Location:30 → 230
      prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      27496598..27503237
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35257.1 GenPept UniProtKB/Swiss-Prot:O35257

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