Mapk11 mitogen-activated protein kinase 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mapk11provided by MGI
Official Full Name: mitogen-activated protein kinase 11provided by MGI
Primary source: MGI:MGI:1338024
See related: Ensembl:ENSMUSG00000053137 AllianceGenome:MGI:1338024
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: P38b; Sapk2; p38-2; Prkm11; Sapk2b; p38beta; p38beta2
Summary: Enables MAP kinase activity. Involved in MAPK cascade; bone development; and osteoblast differentiation. Acts upstream of or within negative regulation of cardiac muscle cell proliferation. Is active in cytosol. Is expressed in genitourinary system; lung; nervous system; and sensory organ. Orthologous to human MAPK11 (mitogen-activated protein kinase 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in cortex adult (RPKM 22.5), CNS E14 (RPKM 20.2) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 E3; 15 44.66 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (89026685..89033809, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (89142482..89149606, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

p38 Mitogen-activated protein kinase regulates chamber-specific perinatal growth in heart.
Title: p38 Mitogen-activated protein kinase regulates chamber-specific perinatal growth in heart.
The current study reveals that ActRIIB activation by activin A induces muscle catabolism primarily through the activation of p38beta MAPK-mediated catabolic signalling that activates the ubiquitin-proteasome pathway and the autophagy-lysosome pathway.
Title: Activin A induces skeletal muscle catabolism via p38β mitogen-activated protein kinase.
in the current study, we used interval mapping to validate a locus on Chr 15, named Ity8, linked to Salmonella resistance in AcB60 mice. Global gene expression analysis during infection identified AcB60-specific expression of genes involved in Ccr7 signaling, including downstream effector Mapk11 (mitogen-activated protein kinase 11), located within the Ity8 interval, and representing a potential positional candidate gene
Title: Complex genetics architecture contributes to Salmonella resistance in AcB60 mice.
propose that active p38-Mapk14/11 act as enablers, and Erk1/2 as drivers, of primitive endoderm differentiation during inner cell mass lineage specification and segregation.
Title: p38 (Mapk14/11) occupies a regulatory node governing entry into primitive endoderm differentiation during preimplantation mouse embryo development.
Double deficiency of p38alpha and p38beta in naive CD4(+) T cells resulted in an attenuation of MAPK-activated protein kinase (MK)-dependent mTOR signaling after T cell receptor engagement, and enhanced their differentiation into regulatory T cells under appropriate inducing conditions.
Title: Loss of Functionally Redundant p38 Isoforms in T Cells Enhances Regulatory T Cell Induction.
Results provide evidence that p38beta is an unusual enzyme that automodulates its basal, MAPKK-independent activity by several autophosphorylation events, which enhance and suppress its catalytic activity.
Title: p38β Mitogen-Activated Protein Kinase Modulates Its Own Basal Activity by Autophosphorylation of the Activating Residue Thr180 and the Inhibitory Residues Thr241 and Ser261.
Data indicate that alternatively activated p38alpha and p38beta up-regulates the transcription factors NFATc1 and IRF4.
Title: Counter-regulation of T cell effector function by differentially activated p38.
the cell autonomous defect in self-renewal in satellite cells from aged mice is due to an impaired response to FGF ligands and elevated p38alpha/beta MAPK activity
Title: p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice.
work reveals a 'seed and soil' mechanism where TGF-beta2 and TGF-beta-RIII signalling through p38alpha/beta regulates DTC dormancy and defines restrictive (BM) and permissive (lung) microenvironments for HNSCC metastasis
Title: TGF-β2 dictates disseminated tumour cell fate in target organs through TGF-β-RIII and p38α/β signalling.
Results suggest that UBR2 up-regulation in cachectic muscle is mediated by the p38beta-C/EBPbeta signaling pathway responsible for the bulk of tumor-induced muscle proteolysis.
Title: Signaling mechanism of tumor cell-induced up-regulation of E3 ubiquitin ligase UBR2.

Submit: New GeneRIF Correction See all GeneRIFs (36)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (10) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D15Jmp9 (e-PCR), detects polymorphism
- UniSTS:472887

Mapk11 (e-PCR), detects polymorphism
- UniSTS:515955

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables MAP kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables MAP kinase activity	ISO Inferred from Sequence Orthology more info
enables MAP kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	EXP Inferred from Experiment more info	PubMed
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	TAS Traceable Author Statement more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in bone development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of cardiac muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to UV-B	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interleukin-1	ISO Inferred from Sequence Orthology more info
involved_in cellular response to virus	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of cardiac muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in p38MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-12 production	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cardiac muscle cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in stress-activated MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in stress-activated MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in stress-activated protein kinase signaling cascade	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: mitogen-activated protein kinase 11

Names: MAP kinase 11; MAP kinase p38 beta; MAPK 11; mitogen-activated protein kinase p38 beta; protein kinase, mitogen activated kinase, 11, p38beta

NP_035291.4

EC 2.7.11.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.