Prkar1b protein kinase, cAMP dependent regulatory, type I beta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prkar1bprovided by MGI
Official Full Name: protein kinase, cAMP dependent regulatory, type I betaprovided by MGI
Primary source: MGI:MGI:97759
See related: Ensembl:ENSMUSG00000025855 AllianceGenome:MGI:97759
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RIbeta
Summary: Predicted to enable cAMP binding activity; cAMP-dependent protein kinase inhibitor activity; and protein kinase A catalytic subunit binding activity. Involved in modulation of chemical synaptic transmission and regulation of synaptic vesicle cycle. Acts upstream of or within learning or memory. Located in hippocampal mossy fiber to CA3 synapse and multivesicular body. Part of cAMP-dependent protein kinase complex. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; peripheral nervous system ganglion; and sensory organ. Orthologous to human PRKAR1B (protein kinase cAMP-dependent type I regulatory subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cortex adult (RPKM 158.4), frontal lobe adult (RPKM 140.4) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 77.74 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (139003059..139136458, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (139017304..139150703, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EZH2 ensures normal cortical differentiation by repression of phosphodiesterases PDE1B, 3A, and 7A and of PRKAR1B.
Title: Steroidogenic differentiation and PKA signaling are programmed by histone methyltransferase EZH2 in the adrenal cortex.
Study reports that mouse R1beta gene produces three alternative splice variants (designated as mR1beta1, mR1beta2 and mR1beta3) that have different N-terminal protein structures.
Title: Two novel N-terminal coding exons of Prkar1b gene of mouse: identified using a novel approach of in silico and molecular biology techniques.
Three transcripts that arise due to alternative splicing in pre-mRNA and alternative promoter usage in 5' UTR of Prkar1b gene, are demonstrated.
Title: Differentially expressed three non-coding alternate exons at 5' UTR of regulatory type I beta subunit gene of mouse.
Activation/accumulation of beta I protein kinase C is involved in superoxide (O2-) production, primarily initiated at the phagosomal cup/phagosome during Fc gamma receptor-mediated phagocytosis in microglia.
Title: Superoxide production at phagosomal cup/phagosome through beta I protein kinase C during Fc gamma R-mediated phagocytosis in microglia.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Prkar1b (e-PCR), detects polymorphism
- UniSTS:507176

Prkar1b (e-PCR), detects polymorphism
- UniSTS:144259

RH132420 (e-PCR)
- UniSTS:215703

AI385716 (e-PCR)
- UniSTS:159466

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cAMP binding	IBA Inferred from Biological aspect of Ancestor more info
enables cAMP binding	ISO Inferred from Sequence Orthology more info
enables cAMP-dependent protein kinase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cAMP-dependent protein kinase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables cAMP-dependent protein kinase regulator activity	ISO Inferred from Sequence Orthology more info
enables cAMP-dependent protein kinase regulator activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase A catalytic subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase A catalytic subunit binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within animal organ morphogenesis	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within learning or memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cAMP-dependent protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cAMP-dependent protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fear response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein phosphorylation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic vesicle cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic vesicle cycle	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
part_of cAMP-dependent protein kinase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cAMP-dependent protein kinase complex	IDA Inferred from Direct Assay more info	PubMed
part_of cAMP-dependent protein kinase complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in hippocampal mossy fiber to CA3 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in hippocampal mossy fiber to CA3 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in multivesicular body	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cAMP-dependent protein kinase type I-beta regulatory subunit

NP_001240819.1

EC 2.7.11.1

NP_001346026.1

EC 2.7.11.1

NP_001346027.1

EC 2.7.11.1

NP_001346028.1

EC 2.7.11.1

NP_001346029.1

EC 2.7.11.1

NP_001346030.1

EC 2.7.11.1

NP_001408231.1

EC 2.7.11.1

NP_032949.3

EC 2.7.11.1

XP_006504723.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001253890.1 → NP_001240819.1 cAMP-dependent protein kinase type I-beta regulatory subunit isoform a

See identical proteins and their annotated locations for NP_001240819.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Variants 1-6 all encode the same isoform (a).

Source sequence(s)

AK158994, AK161621, BU560122, BU844021, CJ290554, CK332907

Consensus CDS

CCDS19803.1

UniProtKB/Swiss-Prot

P12849

UniProtKB/TrEMBL

Q3TY04, Q921L9

Related

ENSMUSP00000106515.2, ENSMUST00000110890.8

Conserved Domains (2) summary

cd12102
Location:11 → 64

DD_RIbeta_PKA; Dimerization/Docking domain of the Type I beta Regulatory subunit of cAMP-dependent protein kinase

cd00038
Location:255 → 370

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
NM_001359097.1 → NP_001346026.1 cAMP-dependent protein kinase type I-beta regulatory subunit isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (3) represents the longest transcript and encodes the longer isoform (a). Variants 1-6 all encode the same isoform (a).

Source sequence(s)

AC117698, AC125065

Consensus CDS

CCDS19803.1

UniProtKB/Swiss-Prot

P12849

UniProtKB/TrEMBL

Q3TY04, Q921L9

Conserved Domains (2) summary

cd12102
Location:11 → 64

DD_RIbeta_PKA; Dimerization/Docking domain of the Type I beta Regulatory subunit of cAMP-dependent protein kinase

cd00038
Location:255 → 370

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
NM_001359098.1 → NP_001346027.1 cAMP-dependent protein kinase type I-beta regulatory subunit isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. Variants 1-6 all encode the same isoform (a).

Source sequence(s)

AC117698, JF720023

Consensus CDS

CCDS19803.1

UniProtKB/Swiss-Prot

P12849

UniProtKB/TrEMBL

Q3TY04, Q921L9

Conserved Domains (2) summary

cd12102
Location:11 → 64

DD_RIbeta_PKA; Dimerization/Docking domain of the Type I beta Regulatory subunit of cAMP-dependent protein kinase

cd00038
Location:255 → 370

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
NM_001359099.1 → NP_001346028.1 cAMP-dependent protein kinase type I-beta regulatory subunit isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 3. Variants 1-6 all encode the same isoform (a).

Source sequence(s)

AC117698, AC125065

Consensus CDS

CCDS19803.1

UniProtKB/Swiss-Prot

P12849

UniProtKB/TrEMBL

Q3TY04, Q921L9

Conserved Domains (2) summary

cd12102
Location:11 → 64

DD_RIbeta_PKA; Dimerization/Docking domain of the Type I beta Regulatory subunit of cAMP-dependent protein kinase

cd00038
Location:255 → 370

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
NM_001359100.1 → NP_001346029.1 cAMP-dependent protein kinase type I-beta regulatory subunit isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 3. Variants 1-6 all encode the same isoform (a).

Source sequence(s)

AC117698, AC125065

Consensus CDS

CCDS19803.1

UniProtKB/Swiss-Prot

P12849

UniProtKB/TrEMBL

Q3TY04, Q921L9

Conserved Domains (2) summary

cd12102
Location:11 → 64

DD_RIbeta_PKA; Dimerization/Docking domain of the Type I beta Regulatory subunit of cAMP-dependent protein kinase

cd00038
Location:255 → 370

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
NM_001359101.1 → NP_001346030.1 cAMP-dependent protein kinase type I-beta regulatory subunit isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.

Source sequence(s)

AC117698, AC125065

Consensus CDS

CCDS90004.1

UniProtKB/TrEMBL

D3Z0V6

Related

ENSMUSP00000106514.2, ENSMUST00000110889.8

Conserved Domains (1) summary

cd00038
Location:131 → 246

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
NM_001421302.1 → NP_001408231.1 cAMP-dependent protein kinase type I-beta regulatory subunit isoform a

Status: VALIDATED

Source sequence(s)

AC117698, AC125065

UniProtKB/Swiss-Prot

P12849
NM_008923.3 → NP_032949.3 cAMP-dependent protein kinase type I-beta regulatory subunit isoform a

See identical proteins and their annotated locations for NP_032949.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1-6 all encode the same isoform (a).

Source sequence(s)

AK158994, AK161621, BB429442, BY237508, CD775616, CO425808

Consensus CDS

CCDS19803.1

UniProtKB/Swiss-Prot

P12849

UniProtKB/TrEMBL

Q3TY04, Q921L9

Related

ENSMUSP00000026973.8, ENSMUST00000026973.14

Conserved Domains (2) summary

cd12102
Location:11 → 64

DD_RIbeta_PKA; Dimerization/Docking domain of the Type I beta Regulatory subunit of cAMP-dependent protein kinase

cd00038
Location:255 → 370

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

139003059..139136458 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006504660.4 → XP_006504723.1 cAMP-dependent protein kinase type I-beta regulatory subunit isoform X1

See identical proteins and their annotated locations for XP_006504723.1

UniProtKB/Swiss-Prot

P12849

UniProtKB/TrEMBL

Q3TY04, Q921L9

Conserved Domains (2) summary

cd12102
Location:11 → 64

DD_RIbeta_PKA; Dimerization/Docking domain of the Type I beta Regulatory subunit of cAMP-dependent protein kinase

cd00038
Location:255 → 370

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...