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    Ppp1cb protein phosphatase 1 catalytic subunit beta [ Mus musculus (house mouse) ]

    Gene ID: 19046, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Ppp1cbprovided by MGI
    Official Full Name
    protein phosphatase 1 catalytic subunit betaprovided by MGI
    Primary source
    MGI:MGI:104871
    See related
    Ensembl:ENSMUSG00000014956 AllianceGenome:MGI:104871
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1200010B19
    Summary
    Enables protein serine/threonine phosphatase activity. Involved in circadian regulation of gene expression; entrainment of circadian clock by photoperiod; and protein dephosphorylation. Located in cytoplasm. Is expressed in cornea; lens epithelium; lens fiber; limb; and retina. Human ortholog(s) of this gene implicated in Noonan syndrome-like disorder with loose anagen hair 2. Orthologous to human PPP1CB (protein phosphatase 1 catalytic subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in bladder adult (RPKM 116.5), liver E14 (RPKM 43.7) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 17.33 cM; 5 B1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (32616192..32651057)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (32458848..32493713)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene phospholipase B1 Neighboring gene predicted gene, 36840 Neighboring gene STARR-seq mESC enhancer starr_12791 Neighboring gene STARR-seq mESC enhancer starr_12792 Neighboring gene STARR-seq mESC enhancer starr_12794 Neighboring gene PDZ and LIM domain protein 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_12795 Neighboring gene predicted gene 15614 Neighboring gene STARR-seq mESC enhancer starr_12798 Neighboring gene methyltransferase-like protein 4 pseudogene Neighboring gene STARR-seq mESC enhancer starr_12799 Neighboring gene STARR-positive B cell enhancer ABC_E8048 Neighboring gene predicted gene 10461 Neighboring gene YES proto-oncogene 1, Src family tyrosine kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The dominant protein phosphatase PP1c isoform in smooth muscle cells, PP1cβ, is essential for smooth muscle contraction. Chang AN, et al. J Biol Chem, 2018 Oct 26. PMID 30185619, Free PMC Article
    2. Phosphoprotein phosphatase 1CB (PPP1CB), a novel adipogenic activator, promotes 3T3-L1 adipogenesis. Cho YL, et al. Biochem Biophys Res Commun, 2015 Nov 13. PMID 26449462
    3. Protein phosphatase 1-dependent transcriptional programs for long-term memory and plasticity. Gräff J, et al. Learn Mem, 2010 Jul. PMID 20592054
    4. Glucose-dependent regulation of AMP-activated protein kinase in MIN6 beta cells is not affected by the protein kinase A pathway. Garcia-Haro L, et al. FEBS Lett, 2012 Nov 30. PMID 23116618
    5. The fission yeast dis2+ gene required for chromosome disjoining encodes one of two putative type 1 protein phosphatases. Ohkura H, et al. Cell, 1989 Jun 16. PMID 2544298

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Smooth muscle-specific conditional PP1cbeta knockout decreased contractile force development in bladder, ileal, and aortic tissues and reduced mouse survival.
      Title: The dominant protein phosphatase PP1c isoform in smooth muscle cells, PP1cβ, is essential for smooth muscle contraction.
    2. PPP1CB is a novel adipogenic activator that promotes adipogenesis in vivo and in vitro.
      Title: Phosphoprotein phosphatase 1CB (PPP1CB), a novel adipogenic activator, promotes 3T3-L1 adipogenesis.
    3. PP-1 is more abundant than PP-2A in the mouse eye; the genes encoding PP-1alpha/beta, PP-2Aalpha/beta, PP-2A-Aalpha/beta, and PP-2A-Balpha/beta/gamma are all differentially expressed.
      Title: Differential expression of the catalytic subunits for PP-1 and PP-2A and the regulatory subunits for PP-2A in mouse eye.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin-light-chain-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphoprotein phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in circadian regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in circadian regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in entrainment of circadian clock by photoperiod IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within glycogen metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of circadian rhythm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of circadian rhythm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of circadian rhythm ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of glycogen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of glycogen catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within rhythmic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of PTW/PP1 phosphatase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in glycogen granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein phosphatase type 1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase PP1-beta catalytic subunit
    Names
    PP-1B
    NP_766295.2
    XP_006503843.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172707.3 → NP_766295.2  serine/threonine-protein phosphatase PP1-beta catalytic subunit

      See identical proteins and their annotated locations for NP_766295.2

      Status: VALIDATED

      Source sequence(s)
      AC102372, AK017392, AK160743, AK166623
      Consensus CDS
      CCDS19193.1
      UniProtKB/Swiss-Prot
      P62141, Q3TBE5, Q3TL90, Q542E7, Q8C285, Q9DBY2
      UniProtKB/TrEMBL
      Q3U7K1
      Related
      ENSMUSP00000015100.9, ENSMUST00000015100.15
      Conserved Domains (1) summary
      cd07414
      Location:7 → 297
      MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      32616192..32651057
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503780.2 → XP_006503843.1  serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1

      Conserved Domains (1) summary
      cl13995
      Location:7 → 197
      MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62141.3 GenPept UniProtKB/Swiss-Prot:P62141

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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