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    Ppox protoporphyrinogen oxidase [ Mus musculus (house mouse) ]

    Gene ID: 19044, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Ppoxprovided by MGI
    Official Full Name
    protoporphyrinogen oxidaseprovided by MGI
    Primary source
    MGI:MGI:104968
    See related
    Ensembl:ENSMUSG00000062729 AllianceGenome:MGI:104968
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ppo
    Summary
    Enables oxygen-dependent protoporphyrinogen oxidase activity. Acts upstream of or within heme biosynthetic process. Is intrinsic component of mitochondrial inner membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Used to study variegate porphyria. Human ortholog(s) of this gene implicated in variegate porphyria. Orthologous to human PPOX (protoporphyrinogen oxidase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver E14.5 (RPKM 89.8), liver E14 (RPKM 78.0) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ppox in Genome Data Viewer
    Location:
    1 H3; 1 79.3 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (171104564..171108955, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (171276991..171281193, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase core subunit S2 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 4 Neighboring gene UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3 Neighboring gene STARR-positive B cell enhancer mm9_chr1:173211225-173211526 Neighboring gene STARR-positive B cell enhancer mm9_chr1:173211857-173212158 Neighboring gene ubiquitin specific peptidase 21 Neighboring gene STARR-seq mESC enhancer starr_03026 Neighboring gene ubiquitin-fold modifier conjugating enzyme 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of the mouse protoporphyrinogen oxidase gene. Dailey TA, et al. Cell Mol Biol (Noisy-le-grand), 2002 Feb. PMID 11929049
    2. Mitochondrial targeting of normal and mutant protoporphyrinogen oxidase. von und zu Fraunberg M, et al. J Biol Chem, 2003 Apr 11. PMID 12556518
    3. A mouse model for South African (R59W) variegate porphyria: construction and initial characterization. Medlock AE, et al. Cell Mol Biol (Noisy-le-grand), 2002 Feb. PMID 11929050
    4. Cloning, sequence, and expression of mouse protoporphyrinogen oxidase. Dailey TA, et al. Arch Biochem Biophys, 1995 Dec 20. PMID 8554330
    5. Induction of terminal enzymes for heme biosynthesis during differentiation of mouse erythroleukemia cells. Taketani S, et al. Eur J Biochem, 1995 Jun 1. PMID 7607249

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. isolation, characterization and localization of gene.
      Title: Characterization of the mouse protoporphyrinogen oxidase gene.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxygen-dependent protoporphyrinogen oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxygen-dependent protoporphyrinogen oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxygen-dependent protoporphyrinogen oxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in heme A biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in heme B biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in heme O biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in heme biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within heme biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in heme biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in porphyrin-containing compound biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protoporphyrinogen IX metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrial intermembrane space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrial intermembrane space ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    protoporphyrinogen oxidase
    Names
    protoporhyrinogen oxidase
    NP_032937.1
    XP_006496770.1
    XP_006496772.1
    XP_011237074.1
    XP_011237075.1
    XP_030108150.1
    XP_030108151.1
    XP_030108152.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008911.2 → NP_032937.1  protoporphyrinogen oxidase

      See identical proteins and their annotated locations for NP_032937.1

      Status: VALIDATED

      Source sequence(s)
      AC084821, AK142632, U25114
      Consensus CDS
      CCDS15487.1
      UniProtKB/Swiss-Prot
      P51175, P97344, Q99M34
      UniProtKB/TrEMBL
      Q3UQA3
      Related
      ENSMUSP00000072863.5, ENSMUST00000073120.11
      Conserved Domains (1) summary
      TIGR00562
      Location:3 → 471
      proto_IX_ox; protoporphyrinogen oxidase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      171104564..171108955 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496707.4 → XP_006496770.1  protoporphyrinogen oxidase isoform X1

      See identical proteins and their annotated locations for XP_006496770.1

      UniProtKB/Swiss-Prot
      P51175, P97344, Q99M34
      UniProtKB/TrEMBL
      Q3UQA3
      Conserved Domains (1) summary
      TIGR00562
      Location:3 → 471
      proto_IX_ox; protoporphyrinogen oxidase

    2. XM_030252290.1 → XP_030108150.1  protoporphyrinogen oxidase isoform X3

      UniProtKB/TrEMBL
      Q3UQA3
      Conserved Domains (1) summary
      TIGR00562
      Location:3 → 388
      proto_IX_ox; protoporphyrinogen oxidase

    3. XM_011238773.3 → XP_011237075.1  protoporphyrinogen oxidase isoform X2

      See identical proteins and their annotated locations for XP_011237075.1

      UniProtKB/TrEMBL
      Q3UQA3
      Conserved Domains (1) summary
      TIGR00562
      Location:18 → 427
      proto_IX_ox; protoporphyrinogen oxidase

    4. XM_030252292.1 → XP_030108152.1  protoporphyrinogen oxidase isoform X4

      Conserved Domains (1) summary
      TIGR00562
      Location:4 → 309
      proto_IX_ox; protoporphyrinogen oxidase

    5. XM_030252291.1 → XP_030108151.1  protoporphyrinogen oxidase isoform X4

      Conserved Domains (1) summary
      TIGR00562
      Location:4 → 309
      proto_IX_ox; protoporphyrinogen oxidase

    6. XM_011238772.3 → XP_011237074.1  protoporphyrinogen oxidase isoform X2

      See identical proteins and their annotated locations for XP_011237074.1

      UniProtKB/TrEMBL
      Q3UQA3
      Conserved Domains (1) summary
      TIGR00562
      Location:18 → 427
      proto_IX_ox; protoporphyrinogen oxidase

    7. XM_006496709.5 → XP_006496772.1  protoporphyrinogen oxidase isoform X3

      UniProtKB/TrEMBL
      Q3UQA3
      Conserved Domains (1) summary
      TIGR00562
      Location:3 → 388
      proto_IX_ox; protoporphyrinogen oxidase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P51175.1 GenPept UniProtKB/Swiss-Prot:P51175

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