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    Ppfibp2 PTPRF interacting protein, binding protein 2 (liprin beta 2) [ Mus musculus (house mouse) ]

    Gene ID: 19024, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Ppfibp2provided by MGI
    Official Full Name
    PTPRF interacting protein, binding protein 2 (liprin beta 2)provided by MGI
    Primary source
    MGI:MGI:894649
    See related
    Ensembl:ENSMUSG00000036528 AllianceGenome:MGI:894649
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cclp1
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in neuromuscular junction development. Predicted to be active in presynaptic active zone. Is expressed in several structures, including alimentary system; bone; brain ventricle and choroid plexus; genitourinary system; and hemolymphoid system gland. Orthologous to human PPFIBP2 (PPFIA binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in bladder adult (RPKM 12.0), placenta adult (RPKM 5.7) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 E3; 7 57.21 cM
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (107192608..107347790)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (107595047..107748583)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene synaptotagmin IX Neighboring gene STARR-seq mESC enhancer starr_19764 Neighboring gene STARR-positive B cell enhancer ABC_E8198 Neighboring gene olfactomedin-like 1 Neighboring gene STARR-positive B cell enhancer ABC_E1352 Neighboring gene STARR-seq mESC enhancer starr_19765 Neighboring gene STARR-seq mESC enhancer starr_19766 Neighboring gene STARR-positive B cell enhancer mm9_chr7:114807884-114808185 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:114846576-114846777 Neighboring gene STARR-seq mESC enhancer starr_19769 Neighboring gene STARR-seq mESC enhancer starr_19770 Neighboring gene cytochrome b5 reductase 2 Neighboring gene ovochymase 2 Neighboring gene olfactory receptor family 5 subfamily P member 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cloning and expression analysis of mouse Cclp1, a new gene encoding a coiled-coil-like protein. Noben-Trauth K, et al. Biochim Biophys Acta, 1997 May 30. PMID 9199242
    2. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    3. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC117695

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in neuromuscular junction development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in presynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynaptic active zone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    liprin-beta-2
    Names
    PTPRF-interacting protein-binding protein 2
    coiled-coil-like protein 1
    protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2
    protein tyrosine phosphatase, receptor-type, F interacting protein, binding protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163557.2 → NP_001157029.1  liprin-beta-2 isoform 2

      See identical proteins and their annotated locations for NP_001157029.1

      Status: VALIDATED

      Source sequence(s)
      AL513346
      Consensus CDS
      CCDS52356.1
      UniProtKB/Swiss-Prot
      O35711, Q497W6, Q7TMG4, Q8CBS6, Q99KX6
      Related
      ENSMUSP00000095738.4, ENSMUST00000098134.5
      Conserved Domains (5) summary
      cd09563
      Location:550 → 613
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:624 → 686
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:709 → 780
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      smart00454
      Location:550 → 614
      SAM; Sterile alpha motif
      pfam01519
      Location:110 → 161
      DUF16; Protein of unknown function DUF16

    2. NM_001357436.2 → NP_001344365.1  liprin-beta-2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL513346
      UniProtKB/Swiss-Prot
      O35711, Q497W6, Q7TMG4, Q8CBS6, Q99KX6
      Conserved Domains (4) summary
      cd09563
      Location:484 → 547
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:558 → 620
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:643 → 714
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      cl25732
      Location:28 → 231
      SMC_N; RecF/RecN/SMC N terminal domain

    3. NM_001357437.2 → NP_001344366.1  liprin-beta-2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL513346
      UniProtKB/Swiss-Prot
      O35711, Q497W6, Q7TMG4, Q8CBS6, Q99KX6
      Conserved Domains (4) summary
      cd09563
      Location:473 → 536
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:547 → 609
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:632 → 703
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      cl25732
      Location:28 → 231
      SMC_N; RecF/RecN/SMC N terminal domain

    4. NM_001357438.2 → NP_001344367.1  liprin-beta-2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL513346
      UniProtKB/Swiss-Prot
      O35711, Q497W6, Q7TMG4, Q8CBS6, Q99KX6
      Conserved Domains (4) summary
      cd09563
      Location:400 → 463
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:474 → 536
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:559 → 630
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      cl25732
      Location:16 → 152
      SMC_N; RecF/RecN/SMC N terminal domain

    5. NM_001417148.1 → NP_001404077.1  liprin-beta-2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL513346

    6. NM_001417149.1 → NP_001404078.1  liprin-beta-2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL513346

    7. NM_001417150.1 → NP_001404079.1  liprin-beta-2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL513346

    8. NM_001417151.1 → NP_001404080.1  liprin-beta-2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL513346

    9. NM_001417152.1 → NP_001404081.1  liprin-beta-2 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL513346

    10. NM_008905.3 → NP_032931.2  liprin-beta-2 isoform 1

      See identical proteins and their annotated locations for NP_032931.2

      Status: VALIDATED

      Source sequence(s)
      AL513346
      Consensus CDS
      CCDS21691.1
      UniProtKB/Swiss-Prot
      O35711, Q497W6, Q7TMG4, Q8CBS6, Q99KX6
      UniProtKB/TrEMBL
      G3X957
      Related
      ENSMUSP00000042574.8, ENSMUST00000040056.15
      Conserved Domains (5) summary
      cd09563
      Location:561 → 624
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:635 → 697
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:720 → 791
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      TIGR02168
      Location:105 → 308
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd22296
      Location:419 → 464
      CBD_TRPV5_C; C-terminal CaM binding domain found in transient receptor potential cation channel subfamily V member 5 (TRPV5) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      107192608..107347790
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152792.1 → XP_036008685.1  liprin-beta-2 isoform X3

      UniProtKB/Swiss-Prot
      O35711, Q497W6, Q7TMG4, Q8CBS6, Q99KX6
      UniProtKB/TrEMBL
      G3X957
      Conserved Domains (5) summary
      cd09563
      Location:561 → 624
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:635 → 697
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:720 → 791
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      TIGR02168
      Location:105 → 308
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd22296
      Location:419 → 464
      CBD_TRPV5_C; C-terminal CaM binding domain found in transient receptor potential cation channel subfamily V member 5 (TRPV5) and similar proteins

    2. XM_030242235.1 → XP_030098095.1  liprin-beta-2 isoform X10

      UniProtKB/Swiss-Prot
      O35711, Q497W6, Q7TMG4, Q8CBS6, Q99KX6
      Conserved Domains (4) summary
      cd09563
      Location:597 → 660
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:671 → 733
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:756 → 827
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      TIGR02168
      Location:141 → 344
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    3. XM_006507443.3 → XP_006507506.1  liprin-beta-2 isoform X1

      UniProtKB/Swiss-Prot
      O35711, Q497W6, Q7TMG4, Q8CBS6, Q99KX6
      Conserved Domains (4) summary
      cd09563
      Location:597 → 660
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:671 → 733
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:756 → 827
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      TIGR02168
      Location:141 → 344
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    4. XM_006507444.3 → XP_006507507.1  liprin-beta-2 isoform X2

      UniProtKB/Swiss-Prot
      O35711, Q497W6, Q7TMG4, Q8CBS6, Q99KX6
      Conserved Domains (4) summary
      cd09563
      Location:586 → 649
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:660 → 722
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:745 → 816
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      TIGR02168
      Location:141 → 344
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    5. XM_006507453.1 → XP_006507516.1  liprin-beta-2 isoform X9

      See identical proteins and their annotated locations for XP_006507516.1

      UniProtKB/Swiss-Prot
      O35711, Q497W6, Q7TMG4, Q8CBS6, Q99KX6
      Conserved Domains (5) summary
      cd09563
      Location:403 → 466
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:477 → 539
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:562 → 633
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      TIGR02168
      Location:8 → 144
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd22296
      Location:261 → 306
      CBD_TRPV5_C; C-terminal CaM binding domain found in transient receptor potential cation channel subfamily V member 5 (TRPV5) and similar proteins

    6. XM_006507454.1 → XP_006507517.1  liprin-beta-2 isoform X9

      See identical proteins and their annotated locations for XP_006507517.1

      UniProtKB/Swiss-Prot
      O35711, Q497W6, Q7TMG4, Q8CBS6, Q99KX6
      Conserved Domains (5) summary
      cd09563
      Location:403 → 466
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:477 → 539
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:562 → 633
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      TIGR02168
      Location:8 → 144
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd22296
      Location:261 → 306
      CBD_TRPV5_C; C-terminal CaM binding domain found in transient receptor potential cation channel subfamily V member 5 (TRPV5) and similar proteins

    7. XM_036152795.1 → XP_036008688.1  liprin-beta-2 isoform X9

      UniProtKB/Swiss-Prot
      O35711, Q497W6, Q7TMG4, Q8CBS6, Q99KX6
      Conserved Domains (5) summary
      cd09563
      Location:403 → 466
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:477 → 539
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:562 → 633
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      TIGR02168
      Location:8 → 144
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd22296
      Location:261 → 306
      CBD_TRPV5_C; C-terminal CaM binding domain found in transient receptor potential cation channel subfamily V member 5 (TRPV5) and similar proteins

    8. XM_006507446.4 → XP_006507509.1  liprin-beta-2 isoform X5

      See identical proteins and their annotated locations for XP_006507509.1

      UniProtKB/Swiss-Prot
      O35711, Q497W6, Q7TMG4, Q8CBS6, Q99KX6
      Conserved Domains (4) summary
      cd09563
      Location:481 → 544
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:555 → 617
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:640 → 711
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      TIGR02168
      Location:25 → 228
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    9. XM_006507452.5 → XP_006507515.1  liprin-beta-2 isoform X9

      See identical proteins and their annotated locations for XP_006507515.1

      UniProtKB/Swiss-Prot
      O35711, Q497W6, Q7TMG4, Q8CBS6, Q99KX6
      Conserved Domains (5) summary
      cd09563
      Location:403 → 466
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:477 → 539
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:562 → 633
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      TIGR02168
      Location:8 → 144
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd22296
      Location:261 → 306
      CBD_TRPV5_C; C-terminal CaM binding domain found in transient receptor potential cation channel subfamily V member 5 (TRPV5) and similar proteins

    10. XM_006507455.5 → XP_006507518.1  liprin-beta-2 isoform X9

      See identical proteins and their annotated locations for XP_006507518.1

      UniProtKB/Swiss-Prot
      O35711, Q497W6, Q7TMG4, Q8CBS6, Q99KX6
      Conserved Domains (5) summary
      cd09563
      Location:403 → 466
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:477 → 539
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:562 → 633
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      TIGR02168
      Location:8 → 144
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd22296
      Location:261 → 306
      CBD_TRPV5_C; C-terminal CaM binding domain found in transient receptor potential cation channel subfamily V member 5 (TRPV5) and similar proteins

    11. XM_006507448.4 → XP_006507511.1  liprin-beta-2 isoform X7

      See identical proteins and their annotated locations for XP_006507511.1

      UniProtKB/Swiss-Prot
      O35711, Q497W6, Q7TMG4, Q8CBS6, Q99KX6
      Conserved Domains (4) summary
      cd09563
      Location:411 → 474
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:485 → 547
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:570 → 641
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      TIGR02168
      Location:16 → 152
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    12. XM_006507449.4 → XP_006507512.1  liprin-beta-2 isoform X7

      See identical proteins and their annotated locations for XP_006507512.1

      UniProtKB/Swiss-Prot
      O35711, Q497W6, Q7TMG4, Q8CBS6, Q99KX6
      Conserved Domains (4) summary
      cd09563
      Location:411 → 474
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:485 → 547
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:570 → 641
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      TIGR02168
      Location:16 → 152
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    13. XM_006507450.4 → XP_006507513.1  liprin-beta-2 isoform X7

      See identical proteins and their annotated locations for XP_006507513.1

      UniProtKB/Swiss-Prot
      O35711, Q497W6, Q7TMG4, Q8CBS6, Q99KX6
      Conserved Domains (4) summary
      cd09563
      Location:411 → 474
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:485 → 547
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:570 → 641
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      TIGR02168
      Location:16 → 152
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    14. XM_006507451.1 → XP_006507514.1  liprin-beta-2 isoform X8

      Conserved Domains (4) summary
      cd09563
      Location:404 → 467
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:478 → 540
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:563 → 634
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      PRK03918
      Location:46 → 197
      PRK03918; DNA double-strand break repair ATPase Rad50
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35711.3 GenPept UniProtKB/Swiss-Prot:O35711

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