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    Ppef2 protein phosphatase, EF hand calcium-binding domain 2 [ Mus musculus (house mouse) ]

    Gene ID: 19023, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ppef2provided by MGI
    Official Full Name
    protein phosphatase, EF hand calcium-binding domain 2provided by MGI
    Primary source
    MGI:MGI:1342304
    See related
    Ensembl:ENSMUSG00000029410 AllianceGenome:MGI:1342304
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable heat shock protein binding activity; mitogen-activated protein kinase kinase kinase binding activity; and protein serine/threonine phosphatase activity. Predicted to be involved in negative regulation of MAPK cascade and negative regulation of peptidyl-threonine phosphorylation. Predicted to act upstream of or within visual perception. Predicted to be active in cytosol and nucleus. Orthologous to human PPEF2 (protein phosphatase with EF-hand domain 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 E2; 5 46.28 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (92374109..92404759, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (92226679..92256278, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 42113 Neighboring gene cDNA sequence U90926 Neighboring gene predicted gene, 42112 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:92674514-92674783 Neighboring gene N-acylethanolamine acid amidase Neighboring gene STARR-positive B cell enhancer ABC_E10329 Neighboring gene STARR-positive B cell enhancer ABC_E2750 Neighboring gene SDA1 domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_13638 Neighboring gene predicted gene, 23031

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression of the Phosphatase Ppef2 Controls Survival and Function of CD8(+) Dendritic Cells. Zwick M, et al. Front Immunol, 2019. PMID 30809231, Free PMC Article
    2. Normal light response, photoreceptor integrity, and rhodopsin dephosphorylation in mice lacking both protein phosphatases with EF hands (PPEF-1 and PPEF-2). Ramulu P, et al. Mol Cell Biol, 2001 Dec. PMID 11713293, Free PMC Article
    3. Identification and characterization of a conserved family of protein serine/threonine phosphatases homologous to Drosophila retinal degeneration C. Sherman PM, et al. Proc Natl Acad Sci U S A, 1997 Oct 14. PMID 9326663, Free PMC Article
    4. Genomic structure and comparative analysis of nine Fugu genes: conservation of synteny with human chromosome Xp22.2-p22.1. Brunner B, et al. Genome Res, 1999 May. PMID 10330123, Free PMC Article
    5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The m[6]A reader YTHDC2 maintains visual function and retinal photoreceptor survival through modulating translation of PPEF2 and PDE6B.
      Title: The m(6)A reader YTHDC2 maintains visual function and retinal photoreceptor survival through modulating translation of PPEF2 and PDE6B.
    2. Expression of the Phosphatase Ppef2 Controls Survival and Function of CD8(+) Dendritic Cells.
      Title: Expression of the Phosphatase Ppef2 Controls Survival and Function of CD8(+) Dendritic Cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Hsp70 protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables Hsp90 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Hsp90 protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mitogen-activated protein kinase kinase kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in detection of stimulus involved in sensory perception IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within visual perception IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase with EF-hands 2
    NP_035278.1
    XP_030110066.1
    XP_036020788.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011148.5 → NP_035278.1  serine/threonine-protein phosphatase with EF-hands 2

      See identical proteins and their annotated locations for NP_035278.1

      Status: VALIDATED

      Source sequence(s)
      AC125542
      Consensus CDS
      CCDS39151.1
      UniProtKB/Swiss-Prot
      O35385
      Related
      ENSMUSP00000144157.2, ENSMUST00000201130.4
      Conserved Domains (5) summary
      smart00015
      Location:21 → 40
      IQ; Calmodulin-binding motif
      smart00156
      Location:141 → 544
      PP2Ac; Protein phosphatase 2A homologues, catalytic domain
      cd00051
      Location:661 → 726
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd07420
      Location:122 → 541
      MPP_RdgC; Drosophila melanogaster RdgC and related proteins, metallophosphatase domain
      pfam13499
      Location:661 → 725
      EF-hand_7; EF-hand domain pair

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      92374109..92404759 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164895.1 → XP_036020788.1  serine/threonine-protein phosphatase with EF-hands 2 isoform X2

      Conserved Domains (3) summary
      COG5126
      Location:344 → 488
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd00051
      Location:424 → 489
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl13995
      Location:12 → 304
      MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain

    2. XM_030254206.1 → XP_030110066.1  serine/threonine-protein phosphatase with EF-hands 2 isoform X1

      Related
      ENSMUSP00000031359.9, ENSMUST00000031359.9
      Conserved Domains (4) summary
      smart00015
      Location:61 → 80
      IQ; Calmodulin-binding motif
      COG5126
      Location:621 → 765
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd00051
      Location:701 → 766
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd07420
      Location:162 → 581
      MPP_RdgC; Drosophila melanogaster RdgC and related proteins, metallophosphatase domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35385.1 GenPept UniProtKB/Swiss-Prot:O35385

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