Cnot7 CCR4-NOT transcription complex, subunit 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cnot7provided by MGI
Official Full Name: CCR4-NOT transcription complex, subunit 7provided by MGI
Primary source: MGI:MGI:1298230
See related: Ensembl:ENSMUSG00000031601 AllianceGenome:MGI:1298230
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Caf1; Pop2; CAF-1
Summary: Enables poly(A)-specific ribonuclease activity. Involved in gene silencing by RNA; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; and positive regulation of nuclear-transcribed mRNA poly(A) tail shortening. Acts upstream of or within P-body assembly and positive regulation of RNA metabolic process. Located in P-body and nucleus. Part of CCR4-NOT complex. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and skeleton. Orthologous to human CNOT7 (CCR4-NOT transcription complex subunit 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E14 (RPKM 22.0), CNS E18 (RPKM 21.1) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 A4; 8 23.89 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (40945579..40968888, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (40492538..40515847, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CNOT7 Outcompetes Its Paralog CNOT8 for Integration into The CCR4-NOT Complex.
Title: CNOT7 Outcompetes Its Paralog CNOT8 for Integration into The CCR4-NOT Complex.
Essential functions of the CNOT7/8 catalytic subunits of the CCR4-NOT complex in mRNA regulation and cell viability.
Title: Essential functions of the CNOT7/8 catalytic subunits of the CCR4-NOT complex in mRNA regulation and cell viability.
This study identifies CNOT7 as an important regulator of RNA transport and translation in dendrites, as well as higher cognitive function.
Title: Dynamic Control of Dendritic mRNA Expression by CNOT7 Regulates Synaptic Efficacy and Higher Cognitive Function.
study reports that a complex of BTG4 and CAF1 safeguards metaphase II arrest in mammalian eggs by deadenylating maternal mRNAs
Title: The BTG4 and CAF1 complex prevents the spontaneous activation of eggs by deadenylating maternal mRNAs.
Cnot7, a key component of deadenylation machinery, are also dormant maternal mRNAs that are recruited during oocyte maturation
Title: Mobilization of Dormant Cnot7 mRNA Promotes Deadenylation of Maternal Transcripts During Mouse Oocyte Maturation.
Collectively, our data support a model of CNOT7, TOB1, CNOT1, and RNA-binding proteins collectively exerting post-transcriptional control on a metastasis suppressive transcriptional program to drive tumor cell metastasis
Title: Post-transcriptional Control of Tumor Cell Autonomous Metastatic Potential by CCR4-NOT Deadenylase CNOT7.
MK2 phosphorylation reduces the ability of TTP to promote deadenylation by inhibiting the recruitment of CAF1 deadenylase in a mechanism that does not involve sequestration of TTP by 14-3-3.
Title: MAPKAP kinase 2 blocks tristetraprolin-directed mRNA decay by inhibiting CAF1 deadenylase recruitment.
Show that a let-7 miRNA-loaded RNA-induced silencing complex interacts with the poly(A)-binding protein and the CAF1 and CCR4 deadenylases for miRNA mediated deadenylation.
Title: Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation.
Gene deletion of Cnot7 caused abnormal sperm morphology in Sertoli cells from knockout mice.
Title: Abnormal sperm morphology caused by defects in Sertoli cells of Cnot7 knockout mice.
Cnot7 is expressed in osteoblasts and is associated with mineralization.
Title: Expression analysis of LacZ gene placed in the locus of Cnot7 exhibits its activity in osteoblasts in vivo and in mineralized nodules in vitro.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3'-5'-RNA exonuclease activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA exonuclease activity	ISO Inferred from Sequence Orthology more info
enables exonuclease activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclease activity	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables poly(A)-specific ribonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables poly(A)-specific ribonuclease activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables poly(A)-specific ribonuclease activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within P-body assembly	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within deadenylation-dependent decapping of nuclear-transcribed mRNA	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within deadenylation-dependent decapping of nuclear-transcribed mRNA	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type I interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within nuclear-transcribed mRNA poly(A) tail shortening	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
involved_in regulatory ncRNA-mediated gene silencing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of CCR4-NOT complex	IPI Inferred from Physical Interaction more info	PubMed
part_of CCR4-NOT complex	ISO Inferred from Sequence Orthology more info
part_of CCR4-NOT core complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in P-body	IBA Inferred from Biological aspect of Ancestor more info
located_in P-body	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in intracellular non-membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: CCR4-NOT transcription complex subunit 7

Names: CCR4-associated factor 1; POP2 homolog; catabolite repressor protein (CCR4)-associative factor 1

NP_001258471.1

EC 3.1.13.4

NP_001258472.1

EC 3.1.13.4

NP_001348867.1

EC 3.1.13.4

NP_001348868.1

EC 3.1.13.4

NP_035265.1

EC 3.1.13.4

XP_006509370.1

EC 3.1.13.4

XP_036009723.1

EC 3.1.13.4

XP_036009724.1

EC 3.1.13.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271542.1 → NP_001258471.1 CCR4-NOT transcription complex subunit 7 isoform 1

See identical proteins and their annotated locations for NP_001258471.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 4 encode the same isoform (1).

Source sequence(s)

AC118012, AK135669, AK147048

Consensus CDS

CCDS22253.1

UniProtKB/Swiss-Prot

Q60809

UniProtKB/TrEMBL

Q3V231, Q543X5

Related

ENSMUSP00000122933.2, ENSMUST00000132032.8

Conserved Domains (1) summary

cl23804
Location:1 → 279

CAF1; CAF1 family ribonuclease
NM_001271543.1 → NP_001258472.1 CCR4-NOT transcription complex subunit 7 isoform 2

See identical proteins and their annotated locations for NP_001258472.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.

Source sequence(s)

AC118012

Consensus CDS

CCDS72114.1

UniProtKB/TrEMBL

Q3TLK9, Q3V231

Related

ENSMUSP00000119319.2, ENSMUST00000135269.8

Conserved Domains (1) summary

cl23804
Location:1 → 215

CAF1; CAF1 family ribonuclease
NM_001361938.1 → NP_001348867.1 CCR4-NOT transcription complex subunit 7 isoform 1

Status: VALIDATED

Source sequence(s)

AC118012, AK147048, CN663584

Consensus CDS

CCDS22253.1

UniProtKB/Swiss-Prot

Q60809

UniProtKB/TrEMBL

Q3V231, Q543X5

Related

ENSMUSP00000117304.2, ENSMUST00000149992.2

Conserved Domains (1) summary

cl23804
Location:1 → 279

CAF1; CAF1 family ribonuclease
NM_001361939.1 → NP_001348868.1 CCR4-NOT transcription complex subunit 7 isoform 3

Status: VALIDATED

Source sequence(s)

AC118012, AK147048, CJ166755

UniProtKB/TrEMBL

Q3V231

Conserved Domains (1) summary

cl23804
Location:1 → 292

CAF1; CAF1 family ribonuclease
NM_011135.5 → NP_035265.1 CCR4-NOT transcription complex subunit 7 isoform 1

See identical proteins and their annotated locations for NP_035265.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes isoform . Variants 1, 2 and 4 encode the same isoform (1).

Source sequence(s)

AC118012, AK147048, CJ166755

Consensus CDS

CCDS22253.1

UniProtKB/Swiss-Prot

Q60809

UniProtKB/TrEMBL

Q3V231, Q543X5

Related

ENSMUSP00000034012.4, ENSMUST00000034012.10

Conserved Domains (1) summary

cl23804
Location:1 → 279

CAF1; CAF1 family ribonuclease

RNA

NR_155265.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC118012, AK147048, CJ166755, CN663584, DV653062
NR_155266.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC118012, AK147048, CN663584, DV653062

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

40945579..40968888 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036153830.1 → XP_036009723.1 CCR4-NOT transcription complex subunit 7 isoform X1

UniProtKB/TrEMBL

Q3V231

Conserved Domains (1) summary

cl23804
Location:1 → 228

CAF1; CAF1 family ribonuclease
XM_036153831.1 → XP_036009724.1 CCR4-NOT transcription complex subunit 7 isoform X2

UniProtKB/TrEMBL

Q3TLK9, Q3V231

Conserved Domains (1) summary

cl23804
Location:1 → 215

CAF1; CAF1 family ribonuclease
XM_006509307.3 → XP_006509370.1 CCR4-NOT transcription complex subunit 7 isoform X3

Conserved Domains (1) summary

cl23804
Location:1 → 173

CAF1; CAF1 family ribonuclease