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    Plscr2 phospholipid scramblase 2 [ Mus musculus (house mouse) ]

    Gene ID: 18828, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Plscr2provided by MGI
    Official Full Name
    phospholipid scramblase 2provided by MGI
    Primary source
    MGI:MGI:1270860
    See related
    Ensembl:ENSMUSG00000032372 AllianceGenome:MGI:1270860
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; metal ion binding activity; and signaling receptor binding activity. Acts upstream of or within cellular response to lipopolysaccharide. Located in cytoplasm and nucleus. Is expressed in foregut; inner ear; mesothelium; and urogenital mesentery. Orthologous to human PLSCR1 (phospholipid scramblase 1) and PLSCR2 (phospholipid scramblase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in kidney adult (RPKM 51.4), lung adult (RPKM 5.4) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Plscr2 in Genome Data Viewer
    Location:
    9 E3.3; 9 48.35 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (92157655..92179805)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (92275602..92297752)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31588 Neighboring gene phospholipid scramblase family, member 5 Neighboring gene predicted gene, 31531 Neighboring gene STARR-seq mESC enhancer starr_24896 Neighboring gene STARR-positive B cell enhancer mm9_chr9:92147733-92148034 Neighboring gene STARR-seq mESC enhancer starr_24897 Neighboring gene phospholipid scramblase 1 Neighboring gene microRNA 6386 Neighboring gene phospholipid scramblase 1 like 1 Neighboring gene STARR-seq mESC enhancer starr_24898 Neighboring gene predicted gene 15493 Neighboring gene phospholipid scramblase 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identity of a conserved motif in phospholipid scramblase that is required for Ca2+-accelerated transbilayer movement of membrane phospholipids. Zhou Q, et al. Biochemistry, 1998 Feb 24. PMID 9485382
    2. Stimulation of phosphatidylserine biosynthesis and facilitation of UV-induced apoptosis in Chinese hamster ovary cells overexpressing phospholipid scramblase 1. Yu A, et al. J Biol Chem, 2003 Mar 14. PMID 12509439
    3. Identification of three new members of the phospholipid scramblase gene family. Wiedmer T, et al. Biochim Biophys Acta, 2000 Jul 31. PMID 10930526
    4. Expression of the phospholipid scramblase (PLSCR) gene family during the acute phase response. Lu B, et al. Biochim Biophys Acta, 2007 Sep. PMID 17590392
    5. Protein-protein interaction panel using mouse full-length cDNAs. Suzuki H, et al. Genome Res, 2001 Oct. PMID 11591653, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PLSCR2 is expressed predominantly in the cell nucleus
      Title: Stimulation of phosphatidylserine biosynthesis and facilitation of UV-induced apoptosis in Chinese hamster ovary cells overexpressing phospholipid scramblase 1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables CD4 receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables epidermal growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lead ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mercury ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phospholipid scramblase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipid scramblase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables virus receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylserine exposure on apoptotic cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in plasma membrane phospholipid scrambling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of Fc receptor mediated stimulatory signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mast cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in collagen-containing extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    phospholipid scramblase 2
    Names
    PL scramblase 2
    ca(2+)-dependent phospholipid scramblase 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195084.1 → NP_001182013.1  phospholipid scramblase 2

      See identical proteins and their annotated locations for NP_001182013.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (A) represents the longer transcript. Both variants A and B encode the same protein.
      Source sequence(s)
      AC111125
      Consensus CDS
      CCDS23405.1
      UniProtKB/Swiss-Prot
      O70233, Q921P6, Q9DCW2
      Conserved Domains (2) summary
      pfam03803
      Location:84 → 304
      Scramblase; Scramblase
      cl23807
      Location:10 → 61
      WWbp; WW-domain ligand protein

    2. NM_008880.3 → NP_032906.2  phospholipid scramblase 2

      See identical proteins and their annotated locations for NP_032906.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (B) differs in the 5' UTR compared to variant A. Both variants A and B encode the same protein.
      Source sequence(s)
      AC111125, AK002410, AW261539
      Consensus CDS
      CCDS23405.1
      UniProtKB/Swiss-Prot
      O70233, Q921P6, Q9DCW2
      Related
      ENSMUSP00000034932.8, ENSMUST00000034932.14
      Conserved Domains (2) summary
      pfam03803
      Location:84 → 304
      Scramblase; Scramblase
      cl23807
      Location:10 → 61
      WWbp; WW-domain ligand protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      92157655..92179805
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510857.1 → XP_006510920.1  phospholipid scramblase 2 isoform X1

      Conserved Domains (1) summary
      pfam03803
      Location:97 → 317
      Scramblase

    2. XM_011242676.1 → XP_011240978.1  phospholipid scramblase 2 isoform X2

      See identical proteins and their annotated locations for XP_011240978.1

      Conserved Domains (1) summary
      cl02043
      Location:28 → 215
      LOR; LURP-one-related
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DCW2.3 GenPept UniProtKB/Swiss-Prot:Q9DCW2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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