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    Plaa phospholipase A2, activating protein [ Mus musculus (house mouse) ]

    Gene ID: 18786, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Plaaprovided by MGI
    Official Full Name
    phospholipase A2, activating proteinprovided by MGI
    Primary source
    MGI:MGI:104810
    See related
    Ensembl:ENSMUSG00000028577 AllianceGenome:MGI:104810
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PLAP; Ufd3; PLA2P; 2410007N06; D4Ertd618e
    Summary
    Enables phospholipase A2 activator activity. Involved in several processes, including negative regulation of protein K63-linked ubiquitination; positive regulation of dendrite extension; and ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Acts upstream of or within inflammatory response. Located in cytoplasm; nucleus; and synapse. Orthologous to human PLAA (phospholipase A2 activating protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 9.7), placenta adult (RPKM 8.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 C5; 4 43.34 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (94453371..94491410, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (94565139..94603247, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12656 Neighboring gene STARR-seq mESC enhancer starr_10788 Neighboring gene caspase activity and apoptosis inhibitor 1 Neighboring gene STARR-positive B cell enhancer ABC_E3497 Neighboring gene H3.5 histone Neighboring gene intraflagellar transport 74 Neighboring gene leucine rich repeat containing 19 Neighboring gene microRNA 872

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. miR-203 regulates nociceptive sensitization after incision by controlling phospholipase A2 activating protein expression. Sun Y, et al. Anesthesiology, 2012 Sep. PMID 22846677, Free PMC Article
    2. Cloning of a rat cDNA encoding a protein with high homology to mouse phospholipase A2-activating protein. Wang H, et al. Gene, 1995 Aug 19. PMID 7665086
    3. Phospholipase A2-activating protein is associated with a novel form of leukoencephalopathy. Falik Zaccai TC, et al. Brain, 2017 Feb. PMID 28007986, Free PMC Article
    4. Phospholipase A2 activating protein is required for 1α,25-dihydroxyvitamin D3 dependent rapid activation of protein kinase C via Pdia3. Doroudi M, et al. J Steroid Biochem Mol Biol, 2012 Oct. PMID 22484374
    5. An Armadillo motif in Ufd3 interacts with Cdc48 and is involved in ubiquitin homeostasis and protein degradation. Zhao G, et al. Proc Natl Acad Sci U S A, 2009 Sep 22. PMID 19805280, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We demonstrate that PLAA is essential for neural function, through dual roles of (1) regulating post-endocytic trafficking of signaling receptors necessary for neural development and (2) directing sorting of synaptic vesicle (SV) components during recycling, essential for synaptic function.
      Title: PLAA Mutations Cause a Lethal Infantile Epileptic Encephalopathy by Disrupting Ubiquitin-Mediated Endolysosomal Degradation of Synaptic Proteins.
    2. miR-203 may regulate expression of the novel nociceptive mediator PLAA after incision.
      Title: miR-203 regulates nociceptive sensitization after incision by controlling phospholipase A2 activating protein expression.
    3. Phospholipase A2 activating protein is required for 1alpha,25-dihydroxyvitamin D3 dependent rapid activation of protein kinase C via Pdia3
      Title: Phospholipase A2 activating protein is required for 1α,25-dihydroxyvitamin D3 dependent rapid activation of protein kinase C via Pdia3.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phospholipase A2 activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within inflammatory response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in macroautophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of protein K63-linked ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of dendrite extension IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of phospholipase A2 activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of synaptic vesicle recycling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in prostaglandin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phospholipase A-2-activating protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001424835.1 → NP_001411764.1  phospholipase A-2-activating protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL732597

    2. NM_001424836.1 → NP_001411765.1  phospholipase A-2-activating protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL732597

    3. NM_001424837.1 → NP_001411766.1  phospholipase A-2-activating protein isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL732597

    4. NM_001424838.1 → NP_001411767.1  phospholipase A-2-activating protein isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL732597

    5. NM_001424839.1 → NP_001411768.1  phospholipase A-2-activating protein isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL732597

    6. NM_172695.3 → NP_766283.2  phospholipase A-2-activating protein isoform 1

      See identical proteins and their annotated locations for NP_766283.2

      Status: VALIDATED

      Source sequence(s)
      AL732597
      Consensus CDS
      CCDS18359.1
      UniProtKB/Swiss-Prot
      A4QPD6, P27612, Q8C6C4
      Related
      ENSMUSP00000102724.3, ENSMUST00000107107.9
      Conserved Domains (5) summary
      COG2319
      Location:6 → 296
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:10 → 297
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam08324
      Location:536 → 788
      PUL; PUL domain
      pfam09070
      Location:346 → 459
      PFU; PFU (PLAA family ubiquitin binding)
      sd00039
      Location:69 → 110
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      94453371..94491410 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P27612.4 GenPept UniProtKB/Swiss-Prot:P27612

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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