Pla2g5 phospholipase A2, group V [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pla2g5provided by MGI
Official Full Name: phospholipase A2, group Vprovided by MGI
Primary source: MGI:MGI:101899
See related: Ensembl:ENSMUSG00000041193 AllianceGenome:MGI:101899
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PLA2; sPLA2; PLA2-10
Summary: Enables phospholipase A2 activity and signaling receptor binding activity. Involved in several processes, including arachidonic acid secretion; low-density lipoprotein particle remodeling; and positive regulation of immune effector process. Acts upstream of or within negative regulation of inflammatory response and regulation of macrophage activation. Located in cell surface; early phagosome; and phagolysosome. Is expressed in several structures, including central nervous system; ear; genitourinary system; liver; and peripheral nervous system ganglion. Human ortholog(s) of this gene implicated in familial benign fleck retina. Orthologous to human PLA2G5 (phospholipase A2 group V). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in adrenal adult (RPKM 10.0), heart adult (RPKM 9.8) and 12 other tissues See more
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Genomic context

Location:: 4 D3; 4 70.57 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (138526558..138590784, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (138799247..138863562, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pla2g5 contributes to viral-like-induced lung inflammation through macrophage proliferation and LA/Ffar1 lung cell recruitment.
Title: Pla2g5 contributes to viral-like-induced lung inflammation through macrophage proliferation and LA/Ffar1 lung cell recruitment.
Group V Phospholipase A2 Mediates Endothelial Dysfunction and Acute Lung Injury Caused by Methicillin-Resistant Staphylococcus Aureus.
Title: Group V Phospholipase A(2) Mediates Endothelial Dysfunction and Acute Lung Injury Caused by Methicillin-Resistant Staphylococcus Aureus.
Lipid Profile of Activated Macrophages and Contribution of Group V Phospholipase A2.
Title: Lipid Profile of Activated Macrophages and Contribution of Group V Phospholipase A(2).
Lysosome-mediated autophagy pathway contributes to gVPLA2 clearance from lung endothelial cells.
Title: Degradation of group V secretory phospholipase A(2) in lung endothelium is mediated by autophagy.
macrophage-associated Pla2g5 contributes significantly to type-2 immunity through regulation of IL-33 induction and free fatty acids-driven group 2 innate lymphoid cell activation
Title: Macrophages regulate lung ILC2 activation via Pla2g5-dependent mechanisms.
Deficiency of GV sPLA2 results in diminished glucose-stimulated insulin secretion in isolated pancreatic beta-cells
Title: The dual role of group V secretory phospholipase A(2) in pancreatic β-cells.
GV sPLA2 is involved in the maintenance of tubular cell function and integrity, promoting sodium retention through increased cortical (Na+ + K+)-ATPase expression and activity.
Title: Group V Secretory Phospholipase A2 Is Involved in Tubular Integrity and Sodium Handling in the Kidney.
AdPLA2 plays an important role in promoting tumorigenesis and disease progression by modulating the production of prostaglandins and may serve as a potential therapeutic target in TSC and LAM.
Title: Rapamycin-insensitive up-regulation of adipocyte phospholipase A2 in tuberous sclerosis and lymphangioleiomyomatosis.
PLA2G5 hydrolyzed phosphatidylcholine in fat-overladen low-density lipoprotein to release unsaturated fatty acids, which prevented palmitate-induced M1 macrophage polarization.
Title: The adipocyte-inducible secreted phospholipases PLA2G5 and PLA2G2E play distinct roles in obesity.
Key Data shows the role of group v secreted phospholipase A2 in Th2 cytokine and dendritic cell-driven airway hyperresponsiveness and remodeling.
Title: Key role of group v secreted phospholipase A2 in Th2 cytokine and dendritic cell-driven airway hyperresponsiveness and remodeling.

Submit: New GeneRIF Correction See all GeneRIFs (35)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (5) 1 citation
Endonuclease-mediated (3)

General gene information

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Markers

PMC22985P1 (e-PCR)
- UniSTS:272176

Pla2g2a (e-PCR), detects polymorphism
- UniSTS:144210

AW743154 (e-PCR)
- UniSTS:207702

BB273932 (e-PCR)
- UniSTS:207703

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipase A2 activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipase A2 activity	ISO Inferred from Sequence Orthology more info
enables calcium-independent phospholipase A2 activity	ISO Inferred from Sequence Orthology more info
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phospholipase A2 activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in arachidonic acid secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in arachidonic acid secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in arachidonic acid secretion	ISO Inferred from Sequence Orthology more info
involved_in cardiolipin acyl-chain remodeling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in leukotriene biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in low-density lipoprotein particle remodeling	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within low-density lipoprotein particle remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of T cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phagocytosis	IEA Inferred from Electronic Annotation more info
involved_in phagosome-lysosome fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylcholine catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phospholipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in phospholipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in platelet activating factor biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of antifungal innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of immune complex clearance by monocytes and macrophages	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of immune complex clearance by monocytes and macrophages	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage derived foam cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of opsonization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phagosome maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phospholipase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of macrophage activation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in early phagosome	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in phagolysosome	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: phospholipase A2 group V

Names: calcium-dependent phospholipase A2; group V phospholipase A2; phosphatidylcholine 2-acylhydrolase 5

NP_001116426.1

EC 3.1.1.4

NP_001411736.1

EC 3.1.1.4

NP_001411737.1

EC 3.1.1.4

NP_035240.3

EC 3.1.1.4

XP_006538721.2

EC 3.1.1.4

XP_017175533.1

EC 3.1.1.4

XP_036019728.1

EC 3.1.1.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001122954.2 → NP_001116426.1 phospholipase A2 group V precursor

See identical proteins and their annotated locations for NP_001116426.1

Status: VALIDATED

Source sequence(s)

AL844178

Consensus CDS

CCDS18834.1

UniProtKB/Swiss-Prot

P97391, Q9QZU6

UniProtKB/TrEMBL

E9PZD1, Q6GTW1

Related

ENSMUSP00000030524.8, ENSMUST00000030524.14

Conserved Domains (1) summary

cd00125
Location:21 → 137

PLA2c; Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a metal-dependent ...
NM_001424807.1 → NP_001411736.1 phospholipase A2 group V precursor

Status: VALIDATED

Source sequence(s)

AL844178

UniProtKB/TrEMBL

E9PZD1, Q6GTW1
NM_001424808.1 → NP_001411737.1 phospholipase A2 group V precursor

Status: VALIDATED

Source sequence(s)

AL844178

UniProtKB/TrEMBL

E9PZD1, Q6GTW1
NM_001429587.1 → NP_001416516.1 phospholipase A2 group V precursor

Status: VALIDATED

Source sequence(s)

AL844178
NM_001429591.1 → NP_001416520.1 phospholipase A2 group V precursor

Status: VALIDATED

Source sequence(s)

AL844178
NM_011110.5 → NP_035240.3 phospholipase A2 group V precursor

See identical proteins and their annotated locations for NP_035240.3

Status: VALIDATED

Source sequence(s)

AL844178

Consensus CDS

CCDS18834.1

UniProtKB/Swiss-Prot

P97391, Q9QZU6

UniProtKB/TrEMBL

E9PZD1, Q6GTW1

Related

ENSMUSP00000099570.5, ENSMUST00000102512.11

Conserved Domains (1) summary

cd00125
Location:21 → 137

PLA2c; Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a metal-dependent ...

RNA

NR_188945.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL844178

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

138526558..138590784 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036163835.1 → XP_036019728.1 phospholipase A2 group V isoform X1

UniProtKB/Swiss-Prot

P97391, Q9QZU6

UniProtKB/TrEMBL

E9PZD1, Q6GTW1

Related

ENSMUSP00000099569.2, ENSMUST00000102511.2

Conserved Domains (1) summary

cd00125
Location:21 → 137

PLA2c; Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a metal-dependent ...
XM_006538658.5 → XP_006538721.2 phospholipase A2 group V isoform X1

See identical proteins and their annotated locations for XP_006538721.2

UniProtKB/Swiss-Prot

P97391, Q9QZU6

UniProtKB/TrEMBL

E9PZD1, Q6GTW1

Conserved Domains (1) summary

cd00125
Location:21 → 137

PLA2c; Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a metal-dependent ...
XM_017320044.1 → XP_017175533.1 phospholipase A2 group V isoform X1

UniProtKB/Swiss-Prot

P97391, Q9QZU6

UniProtKB/TrEMBL

E9PZD1, Q6GTW1

Conserved Domains (1) summary

cd00125
Location:21 → 137

PLA2c; Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a metal-dependent ...