Pla2g2d phospholipase A2, group IID [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pla2g2dprovided by MGI
Official Full Name: phospholipase A2, group IIDprovided by MGI
Primary source: MGI:MGI:1341796
See related: Ensembl:ENSMUSG00000041202 AllianceGenome:MGI:1341796
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GIID; mGIID; Splash; PLA2IID; sPLA2-IID; GIID sPLA2
Summary: Enables calcium-dependent phospholipase A2 activity; heparan sulfate proteoglycan binding activity; and heparin binding activity. Involved in glycerophospholipid metabolic process and regulation of acute inflammatory response to antigenic stimulus. Acts upstream of or within CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation and negative regulation of T cell proliferation. Located in extracellular region. Is expressed in several structures, including alimentary system; brain; gonad; hemolymphoid system gland; and lung. Orthologous to human PLA2G2D (phospholipase A2 group IID). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in spleen adult (RPKM 19.2), mammary gland adult (RPKM 12.3) and 7 other tissues See more
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Genomic context

Location:: 4 D3; 4 70.57 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (138503046..138509363)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (138775735..138782052)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Coronavirus-specific antibody production in middle-aged mice requires phospholipase A2G2D.
Title: Coronavirus-specific antibody production in middle-aged mice requires phospholipase A2G2D.
Secreted Phospholipase PLA2G2D Contributes to Metabolic Health by Mobilizing omega3 Polyunsaturated Fatty Acids in WAT.
Title: Secreted Phospholipase PLA2G2D Contributes to Metabolic Health by Mobilizing ω3 Polyunsaturated Fatty Acids in WAT.
these results underscore a general role of sPLA2-IID as an immunosuppressive sPLA2 that allows the microenvironmental lipid balance toward an anti-inflammatory state, exerting beneficial or detrimental impact depending upon distinct pathophysiological contexts in inflammation and cancer.
Title: Dual Roles of Group IID Phospholipase A2 in Inflammation and Cancer.
found to induce PLA2G2D expression in mice and in human monocyte-derived macrophages
Title: Critical role of phospholipase A2 group IID in age-related susceptibility to severe acute respiratory syndrome-CoV infection.
PLA2G2D in the LNs contributed to mobilization of a pool of polyunsaturated fatty acids.
Title: Lymphoid tissue phospholipase A2 group IID resolves contact hypersensitivity by driving antiinflammatory lipid mediators.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

Pla2g2d (e-PCR), detects polymorphism
- UniSTS:507146

Pla2g2d (e-PCR), detects polymorphism
- UniSTS:144212

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

RH104598 (e-PCR)
- UniSTS:209648

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipase A2 activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipase A2 activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium-dependent phospholipase A2 activity	ISO Inferred from Sequence Orthology more info
enables heparan sulfate proteoglycan binding	IDA Inferred from Direct Assay more info	PubMed
enables heparin binding	IDA Inferred from Direct Assay more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phospholipase A2 activity	IEA Inferred from Electronic Annotation more info
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in arachidonic acid secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of T cell activation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of T cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylcholine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylcholine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylethanolamine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylglycerol metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phospholipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of acute inflammatory response to antigenic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: group IID secretory phospholipase A2

Names: phosphatidylcholine 2-acylhydrolase 2D; secretory-type PLA, stroma-associated homolog

NP_001334159.1

EC 3.1.1.4

NP_035239.1

EC 3.1.1.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347230.1 → NP_001334159.1 group IID secretory phospholipase A2 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate exon and uses a downstream translational start codon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AL844178

Consensus CDS

CCDS84811.1

UniProtKB/TrEMBL

Q3T9Q3

Related

ENSMUSP00000101432.2, ENSMUST00000105806.2
NM_011109.3 → NP_035239.1 group IID secretory phospholipase A2 isoform 1 precursor

See identical proteins and their annotated locations for NP_035239.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AL844178

Consensus CDS

CCDS18833.1

UniProtKB/Swiss-Prot

Q3V4B8, Q9JLK0, Q9WVF6

UniProtKB/TrEMBL

Q3T9Q3, Q3TYT9

Related

ENSMUSP00000030528.3, ENSMUST00000030528.9

Conserved Domains (1) summary

cd00125
Location:20 → 137

PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...