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    Lypla1 lysophospholipase 1 [ Mus musculus (house mouse) ]

    Gene ID: 18777, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Lypla1provided by MGI
    Official Full Name
    lysophospholipase 1provided by MGI
    Primary source
    MGI:MGI:1344588
    See related
    Ensembl:ENSMUSG00000025903 AllianceGenome:MGI:1344588
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    APT-1; LPL-I; Pla1a; Gm39587
    Summary
    Enables palmitoyl-(protein) hydrolase activity. Involved in protein depalmitoylation. Acts upstream of or within negative regulation of Golgi to plasma membrane protein transport. Located in cytosol. Is expressed in several structures, including brain; cardiovascular system; cranium; genitourinary system; and gut. Orthologous to human LYPLA1 (lysophospholipase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver adult (RPKM 20.2), placenta adult (RPKM 17.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 A1; 1 1.79 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (4878046..4916958)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (4807823..4846735)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene pyruvate dehydrogenase (lipoamide) beta pseudogene Neighboring gene mitochondrial ribosomal protein L15 Neighboring gene STARR-seq mESC enhancer starr_00039 Neighboring gene STARR-seq mESC enhancer starr_00040 Neighboring gene STARR-seq mESC enhancer starr_00043 Neighboring gene predicted gene, 57794 Neighboring gene transcription elongation factor A (SII) 1 Neighboring gene high mobility group box 3 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Regiospecificity and catalytic triad of lysophospholipase I. Wang A, et al. J Biol Chem, 1997 Aug 29. PMID 9268342
    2. Cloning, expression, and catalytic mechanism of murine lysophospholipase I. Wang A, et al. J Biol Chem, 1997 May 9. PMID 9139730
    3. Lyplal1 is dispensable for normal fat deposition in mice. Watson RA, et al. Dis Model Mech, 2017 Dec 19. PMID 29084768, Free PMC Article
    4. Palmitoylation couples insulin hypersecretion with β cell failure in diabetes. Dong G, et al. Cell Metab, 2023 Feb 7. PMID 36634673, Free PMC Article
    5. Temporal Profiling Establishes a Dynamic S-Palmitoylation Cycle. Won SJ, et al. ACS Chem Biol, 2018 Jun 15. PMID 29733200, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Endothelial Palmitoylation Cycling Coordinates Vessel Remodeling in Peripheral Artery Disease.
      Title: Endothelial Palmitoylation Cycling Coordinates Vessel Remodeling in Peripheral Artery Disease.
    2. Lyplal1 is dispensable for normal mouse metabolic physiology.
      Title: Lyplal1 is dispensable for normal fat deposition in mice.
    3. Data indicate that thioesterases APT1/APT2 depalmitoylate nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) and zDHHC17 is the strongest candidate palmitoyltransferase for NMNAT2.
      Title: Identification of palmitoyltransferase and thioesterase enzymes that control the subcellular localization of axon survival factor nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2).
    4. Dynamic palmitoylation links cytosol-membrane shuttling of acyl-protein thioesterase-1 and acyl-protein thioesterase-2 with that of proto-oncogene H-ras product and growth-associated protein-43
      Title: Dynamic palmitoylation links cytosol-membrane shuttling of acyl-protein thioesterase-1 and acyl-protein thioesterase-2 with that of proto-oncogene H-ras product and growth-associated protein-43.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: Tcea1

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carboxylic ester hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lysophospholipase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables palmitoyl-(protein) hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables palmitoyl-(protein) hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables palmitoyl-(protein) hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phospholipase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of Golgi to plasma membrane protein transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of aggrephagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein depalmitoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein depalmitoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein depalmitoylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein depalmitoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    acyl-protein thioesterase 1
    Names
    lysoPLA I
    lysophopholipase 1
    lysophospholipase I
    palmitoyl-protein hydrolase
    phospholipase 1a
    NP_001342641.1
    NP_032892.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355712.1 → NP_001342641.1  acyl-protein thioesterase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC102311
      Consensus CDS
      CCDS87810.1
      UniProtKB/TrEMBL
      D3Z111, Q4FK51
      Related
      ENSMUSP00000111191.2, ENSMUST00000115529.8
      Conserved Domains (1) summary
      pfam02230
      Location:11 → 192
      Abhydrolase_2; Phospholipase/Carboxylesterase

    2. NM_008866.3 → NP_032892.1  acyl-protein thioesterase 1 isoform 1

      See identical proteins and their annotated locations for NP_032892.1

      Status: VALIDATED

      Source sequence(s)
      AC102311, AK002674, BQ033435
      Consensus CDS
      CCDS14806.1
      UniProtKB/Swiss-Prot
      P97823, Q3TJZ0, Q7TPX1, Q8BWM6
      UniProtKB/TrEMBL
      Q4FK51
      Related
      ENSMUSP00000027036.5, ENSMUST00000027036.11
      Conserved Domains (2) summary
      COG0596
      Location:24 → 155
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      pfam02230
      Location:11 → 226
      Abhydrolase_2; Phospholipase/Carboxylesterase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      4878046..4916958
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97823.1 GenPept UniProtKB/Swiss-Prot:P97823

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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